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Epidemiological study of women affiliated to the Mutuelle Générale de l’Éducation Nationale and their Family members

France, 1990 - 3000
Reference ID
FRESH-PEF3101-en
Producer(s)
Gianluca;SEVERI
Metadata
DDI/XML JSON
Study website Interactive tools
Created on
Jul 03, 2026
Last modified
Jul 03, 2026
Page views
44
  • Identification
  • Scope
  • Coverage
  • Producers and sponsors
  • Study authorization
  • Sampling
  • Survey instrument
  • Data collection
  • Study activities
  • Quality standards
  • Access policy
  • Data Access
  • Contacts
  • Metadata production

    • Identification

    Survey ID number

    FRESH-PEF3101-en
    Title

    Epidemiological study of women affiliated to the Mutuelle Générale de l’Éducation Nationale and their Family members
    Abbreviation or Acronym

    E3N-Generations
    Country
    Name Country code
    France fr
    Abstract

    The E3N-Generations family study aims to examine health in relation to modern lifestyles among members of the same family across three generations. The E3N-Generations study builds on the E3N study by following the family members of the women who participated in the E3N cohort: the fathers of their children, their children, and their grandchildren.

    Study website: www.e3n-generations.fr
    Kind of Data

    ['Clinical data','Biological data','Socio-demographic data','Environmental / exposure data','Behavioral data','Geospatial data','Economic data','Genetic / genomic data','Participant-reported health data']
    Unit of Analysis

    Individus

    Scope

    Topics
    Topic Vocabulary
    Malignant neoplasms of breast cim-11
    Malignant neoplasms of colon cim-11
    Malignant neoplasms of cervix uteri cim-11
    Asthma cim-11
    Parkinson disease cim-11
    Malignant neoplasms of prostate cim-11
    Cancer of lung cim-11
    Endometriosis cim-11
    Type 2 diabetes mellitus cim-11
    Diseases of the circulatory system cim-11
    Psoriasis cim-11
    Malignant neoplasms of ovary cim-11
    Hodgkin and non-Hodgkin lymphomas cim-11
    Melanoma of skin cim-11
    Malignant neoplasms of skin cim-11
    Age-associated cognitive decline cim-11
    Depression disorder (TM1) cim-11
    Essential hypertension cim-11
    Malignant neoplasm of pancreas cim-11
    Cancer of respiratory tract cim-11
    Malignant neoplasms of rectum cim-11
    Malignant neoplasms of thyroid gland cim-11
    Rheumatoid arthritis cim-11
    Malignant neoplasms of stomach cim-11
    Age-related macular degeneration cim-11
    COVID-19 cim-11
    SARS-CoV-2 cim-11
    Socio-demographic and economic determinants health determinant
    Socio-demographic and economic determinants: Employment health determinant
    Socio-demographic and economic determinants: Income health determinant
    Socio-demographic and economic determinants: Education level health determinant
    Socio-demographic and economic determinants: Age health determinant
    Environmental determinants health determinant
    Environmental determinants: Air quality health determinant
    Environmental determinants: Climate health determinant
    Environmental determinants: Other health determinant
    Healthcare system determinants health determinant
    Healthcare system determinants: Use of care health determinant
    Behavioral determinants health determinant
    Behavioral determinants: Eating habits health determinant
    Behavioral determinants: Physical activity health determinant
    Biological determinants health determinant
    Biological determinants: Genetic predisposition health determinant
    Biological determinants: Aging health determinant
    Biological determinants: Sex health determinant
    food contaminants, persistent pollutants, noise pollution, artificial light at night other environmental determinant
    Keywords
    family environment Lifestyle and behaviour family members family determinants exposome genetics nutrition pharmacoepidemiology e-tools

    Coverage

    Universe

    {
    "level_sex_clusion_I": [
    {
    "concept": {
    "vocab": "MeSH",
    "vocabURI": "D005260"
    },
    "value": "Female"
    },
    {
    "concept": {
    "vocab": "MeSH",
    "vocabURI": "D008297"
    },
    "value": "Male"
    }
    ],
    "level_age_clusion_I": [
    {
    "concept": {
    "vocab": "MeSH",
    "vocabURI": "D055815"
    },
    "value": "Young Adult (19 to 24 years)"
    },
    {
    "concept": {
    "vocab": "MeSH",
    "vocabURI": "D000328"
    },
    "value": "Adult (25 to 44 years)"
    },
    {
    "concept": {
    "vocab": "MeSH",
    "vocabURI": "D008875"
    },
    "value": "Middle Aged (45 to 64 years)"
    },
    {
    "concept": {
    "vocab": "MeSH",
    "vocabURI": "D000368"
    },
    "value": "Aged (65 to 79 years)"
    },
    {
    "concept": {
    "vocab": "MeSH",
    "vocabURI": "D000369"
    },
    "value": "Aged, 80 and over (80 years and more)"
    }
    ],
    "level_type_clusion_I": "General population",
    "level_type_clusion_other": "",
    "clusion_I": "Women included in the E3N cohort (G1), Fathers of E3N women's children (G1) Sons and daughters of E3N women (G2), Grandchildren of E3N women (G3).",
    "clusion_E": ""
    }

    Producers and sponsors

    Primary investigators
    Name
    Gianluca;SEVERI
    Producers
    Name Role
    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) sponsor
    INSTITUT GUSTAVE ROUSSY (IGR) sponsor
    UNIVERSITE PARIS-SACLAY sponsor
    Funding Agency/Sponsor
    Name
    AGENCE NATIONALE DE LA RECHERCHE (ANR)
    MINISTERE DE L’ENSEIGNEMENT SUPERIEUR, DE LA RECHERCHE ET DE L’ESPACE
    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
    INSTITUT GUSTAVE ROUSSY (IGR)
    LIGUE NATIONALE CONTRE LE CANCER (LNCC)
    MGEN
    UNIVERSITE PARIS-SACLAY
    Other Identifications/Acknowledgments
    Name
    ;
    The European EPIC (European Prospective Investigation into Cancer and Nutrition) cohort, whose French component consists of first-generation women from the E3N-Générations cohort. The ELAPSE, EPITHYR, LIFEPATH, and ESCAPE consortia also use data from G1 women. Data from the cohort (G1 women, G1 men, and G2 men) are used in the national SAPRIS and SAPRIS-SERO studies on COVID-19.

    Study authorization

    Agency
    Agency name
    CNIL
    CPP

    Sampling

    Sample frame

    Unit Type

    ['Other']
    Sampling Procedure

    ['{"concept":{"vocab":"CESSDA","vocabURI":"Other"},"value":"Other"}']

    Survey instrument

    Questionnaires

    Access on specific project only
    Methodology notes

    Observational Study

    Data collection

    Dates of Data Collection
    Start End
    1990-01-01 3000-01-01
    Time Method

    Prospective longitudinal
    Frequency of Data Collection

    About every two years
    Mode of data collection
    • {"concept":{"vocab":"CESSDA","vocabURI":"SelfAdministeredQuestionnaire"},"value":"Self-administered questionnaire"}

    Study activities

    Study activities
    Type
    primary evaluation
    Description
    Health event/morbidity Health event/mortality Health care consumption and services Quality of life/health perception
    Type
    secondary evaluation

    Quality standards

    Quality standards
    Standard
    ['ICD-10']
    Other quality statement

    ['Validation of medical conditions by a team of Clinical Research Coordinators (CRCs), who rely on participants' medical records to verify the reported medical conditions.']

    Access policy

    Location of Data Collection

    For G1: The collected data is stored on secure servers approved for hosting health data at Gustave Roussy and is protected by all the security measures in place at the hospital, which continuously manages sensitive medical data. For G2: Raw data is collected via the web-based questionnaire platform (developed by Gide) and hosted on servers certified for hosting health data. The data generated is then stored, as with G1, on secure, HDS-certified servers at Gustave Roussy.

    Data Access

    Access authority
    Name Email
    Elodie;SPEYER elodie.speyer@inserm.fr
    Confidentiality
    Confidentiality declaration text
    Data Access Policy
    Access conditions

    Data Access Procedures for External Teams: Request for Authorization from the E3N-Générations Cohort Data Access Committee
    Citation requirements

    yes
    Deposit requirements

    yes
    Availability Status

    {"extLink":{"title":"COAR","uri":"http://purl.org/coar/access_right/c_16ec"},"value":"Restricted access"}
    Special Permissions
    Indicate if special permissions are required to access a resource Special permissions description
    Yes https://demande-acces-donnees.portail-fresh.fr/signin

    Contacts

    Contacts
    Name Email
    Elodie;SPEYER elodie.speyer@inserm.fr
    CAMILLE;LAPLANCHE camille.laplanche@gustaveroussy.fr

    Metadata production

    DDI Document ID

    FRESH-PEF3101-en
    Producers
    Name
    CAMILLE LAPLANCHE
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