{"doc_desc":{"title":"Epidemiological study of women affiliated to the Mutuelle G\u00e9n\u00e9rale de l\u2019\u00c9ducation Nationale and their Family members","idno":"FRESH-PEF3101-en","producers":[{"name":"CAMILLE LAPLANCHE","affiliation":""}]},"study_desc":{"title_statement":{"idno":"FRESH-PEF3101-en","IDno":{"metadata_no":[{"agency":"PORTAIL EPIDEMIOLOGIE FRANCE (PEF)","code":"3101"},{"agency":"FReSH","code":"FRESH-PEF3101"}],"metadata_yes":[{"code":"FReSH","agency":"FReSH"}]},"title":"Epidemiological study of women affiliated to the Mutuelle G\u00e9n\u00e9rale de l\u2019\u00c9ducation Nationale and their Family members","alternate_title":"E3N-Generations"},"study_authorization":{"agency":[{"name":"CNIL"},{"name":"CPP"}]},"authoring_entity":[{"name":"Gianluca;SEVERI","firstname":"Gianluca","lastname":"SEVERI","type":"investigator","extlink":[{"title":"ORCID","uri":"0000-0001-7157-419X","role":"pi id"},{"title":"IdRef","uri":"198040598","role":"pi id"},{"title":"ROR","uri":"https:\/\/ror.org\/02vjkv261","role":"organisation id"},{"title":"SIREN","uri":"180036048","role":"organisation id"},{"title":"RNSR","uri":"201019083D","role":"labo id"}],"email":"gianluca.severi@inserm.fr","affiliationName":"INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)","PILabo":"Centre for Research in Epidemiology and Population Health (CESP), Exposome and Heredity Team","isContact":false}],"oth_id":[{"name":";","firstname":"","lastname":"","type":"contributor","isContact":"","extlink":[{"title":"ORCID","uri":"","role":"team member id"},{"title":"IdRef","uri":"","role":"team member id"}]},{"name":"","type":"affiliation","teamMemberLabo":"","extlink":[{"title":"RNSR","uri":"","role":"labo id"}]},{"name":"The European EPIC (European Prospective Investigation into Cancer and Nutrition) cohort, whose French component consists of first-generation women from the E3N-G\u00e9n\u00e9rations cohort. The ELAPSE, EPITHYR, LIFEPATH, and ESCAPE consortia also use data from G1 women. Data from the cohort (G1 women, G1 men, and G2 men) are used in the national SAPRIS and SAPRIS-SERO studies on COVID-19.","type":"collaboration"}],"production_statement":{"prod_place":"Epidemiology France Portal (PEF)","producers":[{"name":"INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)","role":"sponsor","extlink":[{"title":"SIREN","uri":"180036048","role":"sponsor id"},{"title":"ROR","uri":"https:\/\/ror.org\/02vjkv261","role":"sponsor id"}]},{"name":"INSTITUT GUSTAVE ROUSSY (IGR)","role":"sponsor","extlink":[{"title":"SIREN","uri":"775741101","role":"sponsor id"},{"title":"ROR","uri":"https:\/\/ror.org\/0321g0743","role":"sponsor id"}]},{"name":"UNIVERSITE PARIS-SACLAY","role":"sponsor","extlink":[{"title":"ROR","uri":"https:\/\/ror.org\/03xjwb503","role":"sponsor id"},{"title":"SIREN","uri":"130026024","role":"sponsor id"}]}],"funding_agencies":[{"name":"AGENCE NATIONALE DE LA RECHERCHE 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PARIS-SACLAY","extlink":[{"title":"SIREN","uri":"130026024"},{"title":"ROR","uri":"https:\/\/ror.org\/03xjwb503"}]}]},"distribution_statement":{"contact":[{"name":"Elodie;SPEYER","lastname":"SPEYER","firstname":"Elodie","type":"contact","email":"elodie.speyer@inserm.fr","affiliationName":"UNIVERSITE PARIS-SACLAY","contactPointLabo":"Centre for Research in Epidemiology and Population Health (CESP), Exposome and Heredity Team","extlink":[{"title":"SIREN","uri":"130026024","role":"organisation id"},{"title":"ROR","uri":"https:\/\/ror.org\/03xjwb503","role":"organisation id"},{"title":"RNSR","uri":"201019083D","role":"labo id"}]},{"name":"CAMILLE;LAPLANCHE","lastname":"LAPLANCHE","firstname":"CAMILLE","type":"contact","email":"camille.laplanche@gustaveroussy.fr","affiliationName":"UNIVERSITE PARIS-SACLAY","contactPointLabo":"Centre for Research in Epidemiology and Population Health (CESP), Exposome and Heredity Team","extlink":[{"title":"SIREN","uri":"130026024","role":"organisation id"},{"title":"ROR","uri":"https:\/\/ror.org\/03xjwb503","role":"organisation id"},{"title":"RNSR","uri":"201019083D","role":"labo id"}]}]},"study_info":{"keywords":[{"keyword":"family environment"},{"keyword":"Lifestyle and behaviour"},{"keyword":"family members"},{"keyword":"family determinants"},{"keyword":"exposome"},{"keyword":"genetics"},{"keyword":"nutrition"},{"keyword":"pharmacoepidemiology"},{"keyword":"e-tools"}],"topics":[{"topic":"Malignant neoplasms of breast","vocab":"cim-11","extLink":[{"title":"CIM-11","uri":"http:\/\/id.who.int\/icd\/entity\/1047754165"}]},{"topic":"Malignant neoplasms of colon","vocab":"cim-11","extLink":[{"title":"CIM-11","uri":"http:\/\/id.who.int\/icd\/entity\/1265576634"}]},{"topic":"Malignant neoplasms of cervix 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system","vocab":"cim-11","extLink":[{"title":"CIM-11","uri":"http:\/\/id.who.int\/icd\/entity\/426429380"}]},{"topic":"Psoriasis","vocab":"cim-11","extLink":[{"title":"CIM-11","uri":"http:\/\/id.who.int\/icd\/entity\/63698555"}]},{"topic":"Malignant neoplasms of ovary","vocab":"cim-11","extLink":[{"title":"CIM-11","uri":"http:\/\/id.who.int\/icd\/entity\/685124533"}]},{"topic":"Hodgkin and non-Hodgkin lymphomas","vocab":"cim-11","extLink":[{"title":"CIM-11","uri":"http:\/\/id.who.int\/icd\/entity\/1891884932"}]},{"topic":"Melanoma of skin","vocab":"cim-11","extLink":[{"title":"CIM-11","uri":"http:\/\/id.who.int\/icd\/entity\/488336723"}]},{"topic":"Malignant neoplasms of skin","vocab":"cim-11","extLink":[{"title":"CIM-11","uri":"http:\/\/id.who.int\/icd\/entity\/1706880799"}]},{"topic":"Age-associated cognitive decline","vocab":"cim-11","extLink":[{"title":"CIM-11","uri":"http:\/\/id.who.int\/icd\/entity\/584231559"}]},{"topic":"Depression disorder (TM1)","vocab":"cim-11","extLink":[{"title":"CIM-11","uri":"http:\/\/id.who.int\/icd\/entity\/480354492"}]},{"topic":"Essential hypertension","vocab":"cim-11","extLink":[{"title":"CIM-11","uri":"http:\/\/id.who.int\/icd\/entity\/761947693"}]},{"topic":"Malignant neoplasm of pancreas","vocab":"cim-11","extLink":[{"title":"CIM-11","uri":"http:\/\/id.who.int\/icd\/entity\/542147910"}]},{"topic":"Cancer of respiratory tract","vocab":"cim-11","extLink":[{"title":"CIM-11","uri":"http:\/\/id.who.int\/icd\/entity\/693315837"}]},{"topic":"Malignant neoplasms of rectum","vocab":"cim-11","extLink":[{"title":"CIM-11","uri":"http:\/\/id.who.int\/icd\/entity\/1113099195"}]},{"topic":"Malignant neoplasms of thyroid gland","vocab":"cim-11","extLink":[{"title":"CIM-11","uri":"http:\/\/id.who.int\/icd\/entity\/447433352"}]},{"topic":"Rheumatoid arthritis","vocab":"cim-11","extLink":[{"title":"CIM-11","uri":"http:\/\/id.who.int\/icd\/entity\/576319925"}]},{"topic":"Malignant neoplasms of stomach","vocab":"cim-11","extLink":[{"title":"CIM-11","uri":"http:\/\/id.who.int\/icd\/entity\/1397617262"}]},{"topic":"Age-related macular degeneration","vocab":"cim-11","extLink":[{"title":"CIM-11","uri":"http:\/\/id.who.int\/icd\/entity\/1514301548"}]},{"topic":"COVID-19","vocab":"cim-11","extLink":[{"title":"CIM-11","uri":"http:\/\/id.who.int\/icd\/entity\/1730556128"}]},{"topic":"SARS-CoV-2","vocab":"cim-11","extLink":[{"title":"CIM-11","uri":"http:\/\/id.who.int\/icd\/entity\/243015485"}]},{"topic":"Socio-demographic and economic determinants","vocab":"health determinant"},{"topic":"Socio-demographic and economic determinants: Employment","vocab":"health determinant"},{"topic":"Socio-demographic and economic determinants: Income","vocab":"health determinant"},{"topic":"Socio-demographic and economic determinants: Education level","vocab":"health determinant"},{"topic":"Socio-demographic and economic determinants: Age","vocab":"health determinant"},{"topic":"Environmental determinants","vocab":"health determinant"},{"topic":"Environmental determinants: Air quality","vocab":"health determinant"},{"topic":"Environmental determinants: Climate","vocab":"health determinant"},{"topic":"Environmental determinants: Other","vocab":"health determinant"},{"topic":"Healthcare system determinants","vocab":"health determinant"},{"topic":"Healthcare system determinants: Use of care","vocab":"health determinant"},{"topic":"Behavioral determinants","vocab":"health determinant"},{"topic":"Behavioral determinants: Eating habits","vocab":"health determinant"},{"topic":"Behavioral determinants: Physical activity","vocab":"health determinant"},{"topic":"Biological determinants","vocab":"health determinant"},{"topic":"Biological determinants: Genetic predisposition","vocab":"health determinant"},{"topic":"Biological determinants: Aging","vocab":"health determinant"},{"topic":"Biological determinants: Sex","vocab":"health determinant"},{"topic":"food contaminants, persistent pollutants, noise pollution, artificial light at night","vocab":"other environmental determinant"}],"purpose":"The familial E3N-Generations study purpose is to study health in relation to the modern way of life in people of the same family over three generations. The E3N-Generations study aims to extend the E3N study by following the descendants of women who participated in the E3N study. The objective is to better understand the onset of major diseases, from genetics, family environment and the environment outside the family. As well as gathering a large amount of prospective epidemiological data, E3N-Generations cohort permit the collection of important information concerning phenotypes and genetics.","abstract":"The E3N-Generations family study aims to examine health in relation to modern lifestyles among members of the same family across three generations. The E3N-Generations study builds on the E3N study by following the family members of the women who participated in the E3N cohort: the fathers of their children, their children, and their grandchildren.\r\n\r\nStudy website: www.e3n-generations.fr","coll_dates":[{"start":"1990-01-01"}],"nation":[{"name":"France","abbreviation":"fr","extLink":{"vocab":"ISO","vocabURI":"fr"}}],"geog_coverage":"","analysis_unit":"Individus","universe":"{\n    \"level_sex_clusion_I\": [\n        {\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"D005260\"\n            },\n            \"value\": \"Female\"\n        },\n        {\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"D008297\"\n            },\n            \"value\": \"Male\"\n        }\n    ],\n    \"level_age_clusion_I\": [\n        {\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"D055815\"\n            },\n            \"value\": \"Young Adult (19 to 24 years)\"\n        },\n        {\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"D000328\"\n            },\n            \"value\": \"Adult (25 to 44 years)\"\n        },\n        {\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"D008875\"\n            },\n            \"value\": \"Middle Aged (45 to 64 years)\"\n        },\n        {\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"D000368\"\n            },\n            \"value\": \"Aged (65 to 79 years)\"\n        },\n        {\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"D000369\"\n            },\n            \"value\": \"Aged, 80 and over (80 years and more)\"\n        }\n    ],\n    \"level_type_clusion_I\": \"General population\",\n    \"level_type_clusion_other\": \"\",\n    \"clusion_I\": \"Women included in the E3N cohort (G1),  Fathers of E3N women's children (G1)  Sons and daughters of E3N women (G2),  Grandchildren of E3N women (G3).\",\n    \"clusion_E\": \"\"\n}","data_kind":"['Clinical data','Biological data','Socio-demographic data','Environmental \/ exposure data','Behavioral data','Geospatial data','Economic data','Genetic \/ genomic data','Participant-reported health data']","quality_statement":{"standards":[{"name":"['ICD-10']","committee":"The Institutional Committee brings together the founding partners: Paris-Saclay University, Inserm, Gustave Roussy, the National League Against Cancer, and MGEN. Its main responsibilities include validating strategic directions, monitoring the cohort\u2019s progress and its budgetary status; approving budget management, financial statements, and annual activity reports; establishing the procedures for evaluating the cohort and deciding on its potential termination or extension; and adopting a Charter governing access to the cohort\u2019s data and samples. The Scientific Advisory Board, composed of international experts, ensures the relevance and scientific quality of research conducted using the cohort\u2019s data and samples; it fosters collaborations by identifying expertise and know-how; and it provides an opinion on the Data Access Charter.","governance":""}],"other_quality_statement":"['Validation of medical conditions by a team of Clinical Research Coordinators (CRCs), who rely on participants' medical records to verify the reported medical conditions.']"}},"study_development":{"development_activity":[{"activity_type":"primary evaluation","activity_description":"Health event\/morbidity\r\nHealth event\/mortality\r\nHealth care consumption and services\r\nQuality of life\/health perception"},{"activity_type":"secondary evaluation","activity_description":""}]},"method":{"data_collection":{"time_method":"Prospective longitudinal","frequency":"About every two years","sampling_procedure":"['{\"concept\":{\"vocab\":\"CESSDA\",\"vocabURI\":\"Other\"},\"value\":\"Other\"}']","sample_frame":{"frame_unit":{"unit_type":"['Other']"}},"coll_mode":["{\"concept\":{\"vocab\":\"CESSDA\",\"vocabURI\":\"SelfAdministeredQuestionnaire\"},\"value\":\"Self-administered questionnaire\"}"],"research_instrument":"Access on specific project only","sources":[{"sourceCitation":{"titlStmt":{"titl":"MGEN Reimbursement Guidelines for Medical Care (for G1 women only)"},"holdings":"","notes":{"subject":"source purpose","value":"Data enrichment through cross-referencing"}},"srcOrig":["Medico-administrative database"]},{"sourceCitation":{"titlStmt":{"titl":"CepiDC"},"holdings":"","notes":{"subject":"source purpose","value":"Passive participant monitoring"}},"srcOrig":["Medico-administrative database"]}],"target_sample_size":">= 20000 individuals","response_rate":"98 995 G1 Women ; 17 700 G1 Men ; 21 000 G2"},"method_notes":"Observational Study","study_class":"Ongoing study","notes":[{"subject":"research type","values":["Observational Study"]},{"subject":"observational study method","values":["Cohort study"]},{"subject":"follow-up","values":["Monitoring by contact with the participant (mail, e-mail, telephone etc.)"]}]},"data_access":{"dataset_availability":{"access_place":"For G1: The collected data is stored on secure servers approved for hosting health data at Gustave Roussy and is protected by all the security measures in place at the hospital, which continuously manages sensitive medical data. For G2: Raw data is collected via the web-based questionnaire platform (developed by Gide) and hosted on servers certified for hosting health data. The data generated is then stored, as with G1, on secure, HDS-certified servers at Gustave Roussy.","complete":"","status":"{\"extLink\":{\"title\":\"COAR\",\"uri\":\"http:\/\/purl.org\/coar\/access_right\/c_16ec\"},\"value\":\"Restricted access\"}"},"dataset_use":{"restrictions":"","conditions":"Data Access Procedures for External Teams: Request for Authorization from the E3N-G\u00e9n\u00e9rations Cohort Data Access Committee","conf_dec":[{"txt":"Data Access Policy"}],"spec_perm":[{"txt":"https:\/\/demande-acces-donnees.portail-fresh.fr\/signin","required":"Yes"}],"contact":[{"name":"Elodie;SPEYER","firstname":"Elodie","lastname":"SPEYER","email":"elodie.speyer@inserm.fr"}],"deposit_req":"yes","cit_req":"yes"},"notes":""}},"additional":{"IsImport":false,"versionLang":"en","originLang":"en","lastUpdatedAuto":"03-07-2026","lastUpdatedManual":"03-07-2026","autoTranslation":false,"status":"Awaiting validation","respValidation":"","isHealthTheme":false,"isContributorPI":false,"addTeamMember":false,"primaryInvestigator":{"isPIContact":false,"piMail":"gianluca.severi@inserm.fr","piAffiliation":{"piLabo":"Centre for Research in Epidemiology and Population Health (CESP), Exposome and Heredity Team"}},"relatedDocument":[{"type":"","title":"Website dedicated to the cohort","link":"www.e3n-generations.fr"}],"contactPointLabo":"Centre for Research in Epidemiology and Population Health (CESP), Exposome and Heredity Team","obtainedAuthorization":{"otherAuthorizingAgency":["",""]},"regulatoryRequirements":{"conformityDeclaration":"MR-001"},"fundingAgent":{"fundingAgentType":["Public (France)","Public (France)","Public (France)","Private non-profit","Private non-profit","Private non-profit","Public (France)"],"otherFundingAgentType":["","","","","","",""]},"sponsor":{"sponsorType":["Public (France)","Private non-profit","Public (France)"],"otherSponsorType":["","",""]},"governance":{"committee":true},"collaborations":{"networkConsortium":true},"theme":{"complementaryInformation":"","RareDiseases":false},"interventionalStudy":{"researchPurpose":[],"trialPhase":[],"interventionalStudyModel":"","isClinicalTrial":"","otherResearchPurpose":""},"isInclusionGroups":true,"allocation":{"allocationMode":"","allocationUnit":""},"masking":{"maskingType":"","blindedMaskingDetails":[]},"arms":[],"intervention":[{"name":"exposome","type":"Public Health","typeOther":""},{"name":"lifestyle","type":"Behavioral","typeOther":""},{"name":"Nutrition","type":"Behavioral","typeOther":""},{"name":"Treatments","type":"Drug","typeOther":""},{"name":"Genes","type":"Genetic","typeOther":""},{"name":"Family History","type":"Genetic","typeOther":""}],"cohortLongitudinal":{"recrutementTiming":[]},"otherResearchType":{"otherResearchTypeDetails":""},"inclusionGroups":[{"name":"First-Generation Women (G1 Women)","description":"The women in the E3N cohort, who form the foundation of the family cohort"},{"name":"First-Generation Men (G1 Men)","description":"The men with whom the G1 women had children"},{"name":"Generation 2 (G2)","description":"The children (sons and daughters) of G1 women"},{"name":"Generation 3 (G3)","description":"The grandchildren (grandsons and granddaughters) of the G1 women"}],"nrInclusionGroups":false,"collectionProcess":{"collectionModeDetails":"For G1: paper self-questionnaires ; For G2 and G3: webquestionnaires, sms, trackers of physical activity; For all: contacts with doctors","collectionModeOther":""},"dataCollection":{"inclusionStrategy":[],"samplingModeOther":"","recruitmentSourceOther":"To establish this family cohort, contact information for the family members of the women in the E3N cohort was collected directly from the women themselves and then from the E3N-G\u00e9n\u00e9rations participants once they were included in the cohort, in order to continue including the second and third generations.","otherDocumentation":""},"activeFollowUp":{"isActiveFollowUp":true,"followUpModeOther":""},"dataCollectionIntegration":{"isDataIntegration":true},"geographicalCoverage":{"geoDetail":"France"},"dataTypes":{"clinicalDataDetails":"Anatomical Pathology Reporting for Declared Cancer","biologicalDataDetails":"Saliva samples (DNA extraction)","isDataInBiobank":true,"biobankContent":["Whole blood","Plasma","Serum","Other fluids and secretions"],"biobankContentOther":"","dataTypeOther":"","paraclinicalDataOther":"","otherLiquidsDetails":"Saliva"},"variableDictionnary":{"variableDictionnaryAvailable":true,"variableDictionnaryLink":"coming soon"},"dataQuality":{"otherDocumentation":""},"mockSample":{"mockSampleAvailable":false,"mockSampleLocation":""},"thirdPartySource":{"otherSourceType":["",""]},"fileDscr":{"fileTxt":{"fileCitation":{"titlStmt":{"IDno":[]}}}}},"schematype":"survey"}