Long-Term Outcomes of Esophageal Atresia: Transomic Profiles in Adolescence

{
"level_sex_clusion_I": [
{
"concept": {
"vocab": "MeSH",
"vocabURI": "D005260"
},
"value": "Female"
},
{
"concept": {
"vocab": "MeSH",
"vocabURI": "D008297"
},
"value": "Male"
}
],
"level_age_clusion_I": [
{
"concept": {
"vocab": "MeSH",
"vocabURI": ""
},
"value": "Prenatal"
},
{
"concept": {
"vocab": "MeSH",
"vocabURI": "D007231"
},
"value": "Infant, Newborn (birth to 28 days)"
},
{
"concept": {
"vocab": "MeSH",
"vocabURI": "D007223"
},
"value": "Infant (28 days to 2 years)"
},
{
"concept": {
"vocab": "MeSH",
"vocabURI": "D002648"
},
"value": "Child (6 to 12 years)"
},
{
"concept": {
"vocab": "MeSH",
"vocabURI": "D000293"
},
"value": "Adolescent (13 to 18 years)"
}
],
"level_type_clusion_I": "Patients population",
"level_type_clusion_other": "",
"clusion_I": "For the EA group:\r\n- Born with esophageal atresia (EA) in France or in the French overseas departments and territories (DOM\/TOM)\r\n- Esophageal anastomosis performed\r\n- Must be 13 or 14 years old during the recruitment period (2023–2026)\r\n- Enrollment in the Renato Registry\r\n- Patient covered by social security\r\n- A patient willing to comply with all study procedures and to participate for the duration of the study\r\n\r\nFor the blood substudy:\r\n- Upper gastrointestinal endoscopy performed as part of medical care between the ages of 10 and 14, with a biopsy of the esophageal mucosa\r\n- Patient who has provided written consent to participate in the study (or in the ancillary study, if applicable, for the centers in Lille, Paris Necker, Paris Robert Debré, Lyon, Marseille, and Grenoble)\r\n\r\n\r\nFor the control group:\r\n- Upper gastrointestinal endoscopy performed between the ages of 10 and 14, with a biopsy of the esophageal mucosa\r\n- Upper gastrointestinal endoscopy performed as part of the management of chronic or acute gastrointestinal symptoms to rule out an organic cause (peptic esophagitis, gastric esophagitis, eosinophilic esophagitis or ulcer)\r\n- Normal endoscopy and histology\r\n- No concurrent progressive chronic disease",
"clusion_E": "Exclusion Criteria\r\n\r\nFor the EA group:\r\n- Concurrent participation in an interventional trial as well as within 3\r\nthe month prior to inclusion\r\n- Parents who refuse to participate in the study\r\n\r\nFor the control group:\r\n- Esophageal biopsy with histologically abnormal findings\r\n- Parents who refuse to participate in the study\r\n- Child with a known organic condition"
}