{"doc_desc":{"title":"Long-Term Outcomes of Esophageal Atresia: Transomic Profiles in Adolescence","idno":"FReSH-43727-en","producers":[{"name":"M\u00e9lanie LEROY","affiliation":""}]},"study_desc":{"title_statement":{"idno":"FReSH-43727-en","IDno":{"metadata_no":[{"agency":"","code":""}],"metadata_yes":[{"code":"FReSH","agency":"FReSH"}]},"title":"Long-Term Outcomes of Esophageal Atresia: Transomic Profiles in Adolescence","alternate_title":"TransEAsome"},"study_authorization":{"agency":[{"name":"CNIL"},{"name":"CPP"}]},"authoring_entity":[{"name":"Fr\u00e9d\u00e9ric;GOTTRAND","firstname":"Fr\u00e9d\u00e9ric","lastname":"GOTTRAND","type":"investigator","extlink":[{"title":"ORCID","uri":"0000-0002-5290-0436","role":"pi id"},{"title":"IdRef","uri":"073432342","role":"pi id"},{"title":"SIREN","uri":"265906719","role":"organisation id"},{"title":"ROR","uri":"https:\/\/ror.org\/02ppyfa04","role":"organisation id"},{"title":"RNSR","uri":"202023580Y","role":"labo 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id"}]},{"name":"Michel;SALZET","firstname":"Michel","lastname":"SALZET","type":"contributor","isContact":true,"extlink":[{"title":"ORCID","uri":"0000-0003-4318-0817","role":"team member id"},{"title":"IdRef","uri":"069436940","role":"team member id"}]},{"name":"INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)","type":"affiliation","teamMemberLabo":"INSERM Northwest\nPRISM","extlink":[{"title":"SIREN","uri":"180036048","role":"organisation id"},{"title":"ROR","uri":"https:\/\/ror.org\/02vjkv261","role":"organisation id"},{"title":"RNSR","uri":"201119484K","role":"labo id"}]},{"name":"Jimmy;VANDEL","firstname":"Jimmy","lastname":"VANDEL","type":"contributor","isContact":true,"extlink":[{"title":"ORCID","uri":"0000-0003-0189-0220","role":"team member id"},{"title":"IdRef","uri":"17162520X","role":"team member id"}]},{"name":"UNIVERSITE DE LILLE","type":"affiliation","teamMemberLabo":"Lille Biology and Health Platforms\nBiLille","extlink":[{"title":"SIREN","uri":"130029754","role":"organisation id"},{"title":"ROR","uri":"https:\/\/ror.org\/02kzqn938","role":"organisation id"},{"title":"RNSR","uri":"202023463W","role":"labo id"}]},{"name":"R\u00e9gis;HANKARD","firstname":"R\u00e9gis","lastname":"HANKARD","type":"contributor","isContact":true,"extlink":[{"title":"ORCID","uri":"0000-0001-8450-5839","role":"team member id"},{"title":"IdRef","uri":"091028760","role":"team member id"}]},{"name":"CENTRE HOSPITALIER UNIVERSITAIRE D ORLEANS (CHUO)","type":"affiliation","teamMemberLabo":"Kids France","extlink":[{"title":"SIREN","uri":"264500091","role":"organisation id"},{"title":"ROR","uri":"https:\/\/ror.org\/04yvax419","role":"organisation id"},{"title":"RNSR","uri":"","role":"labo id"}]},{"name":"the CRACMO network","type":"collaboration"}],"production_statement":{"prod_place":"France Recherche en Sant\u00e9 Humaine (FReSH)","producers":[{"name":"CENTRE HOSPITALIER UNIVERSITAIRE DE LILLE (CHU)","role":"sponsor","extlink":[{"title":"SIREN","uri":"265906719","role":"sponsor id"},{"title":"ROR","uri":"https:\/\/ror.org\/02ppyfa04","role":"sponsor id"}]}],"funding_agencies":[{"name":"AGENCE NATIONALE DE LA RECHERCHE (ANR)","extlink":[{"title":"SIREN","uri":"130002504"},{"title":"ROR","uri":"https:\/\/ror.org\/00rbzpz17"}]}]},"distribution_statement":{"contact":[{"name":"M\u00e9lanie;LEROY","lastname":"LEROY","firstname":"M\u00e9lanie","type":"contact","email":"melanie.leroy@chu-lille.fr","affiliationName":"CENTRE HOSPITALIER UNIVERSITAIRE DE LILLE (CHU)","contactPointLabo":"Department of Pediatric Gastroenterology, Hepatology, and Nutrition \/ Reference Center for Chronic Diseases and Esophageal Malformations (CRACMO)","extlink":[{"title":"SIREN","uri":"265906719","role":"organisation id"},{"title":"ROR","uri":"https:\/\/ror.org\/02ppyfa04","role":"organisation id"},{"title":"RNSR","uri":"202023580Y","role":"labo id"}]},{"name":"Martin;FIGEAC","lastname":"FIGEAC","firstname":"Martin","type":"contact","email":"martin.figeac@univ-lille.fr","affiliationName":"UNIVERSITE DE LILLE","contactPointLabo":"Plateformes Lilloises de Biologie Sant\u00e9\nGo@L","extlink":[{"title":"SIREN","uri":"130029754","role":"organisation id"},{"title":"ROR","uri":"https:\/\/ror.org\/02kzqn938","role":"organisation id"},{"title":"RNSR","uri":"202023463W","role":"labo id"}]},{"name":"Michel;SALZET","lastname":"SALZET","firstname":"Michel","type":"contact","email":"michel.salzet@inserm.fr","affiliationName":"INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)","contactPointLabo":"INSERM Nord Ouest\nPRISM","extlink":[{"title":"SIREN","uri":"180036048","role":"organisation id"},{"title":"ROR","uri":"https:\/\/ror.org\/02vjkv261","role":"organisation id"},{"title":"RNSR","uri":"201119484K","role":"labo id"}]},{"name":"Jimmy;VANDEL","lastname":"VANDEL","firstname":"Jimmy","type":"contact","email":"jimmy.vandel@univ-lille.fr","affiliationName":"UNIVERSITE DE LILLE","contactPointLabo":"Plateformes Lilloises de Biologie Sant\u00e9\nBiLille","extlink":[{"title":"SIREN","uri":"130029754","role":"organisation id"},{"title":"ROR","uri":"https:\/\/ror.org\/02kzqn938","role":"organisation id"},{"title":"RNSR","uri":"202023463W","role":"labo id"}]},{"name":"R\u00e9gis;HANKARD","lastname":"HANKARD","firstname":"R\u00e9gis","type":"contact","email":"regis.hankard@chu-orleans.fr","affiliationName":"CENTRE HOSPITALIER UNIVERSITAIRE D ORLEANS (CHUO)","contactPointLabo":"Kids France","extlink":[{"title":"SIREN","uri":"264500091","role":"organisation id"},{"title":"ROR","uri":"https:\/\/ror.org\/04yvax419","role":"organisation id"},{"title":"RNSR","uri":"","role":"labo id"}]}]},"study_info":{"keywords":[{"keyword":"esophageal atresia"},{"keyword":"pediatrics"},{"keyword":"cohort"},{"keyword":"omic"}],"topics":[{"topic":"Gastroenterology","extLink":[{"title":"ESV","uri":"http:\/\/data.europa.eu\/8mn\/euroscivoc\/a3898340-a42d-4f5e-a822-1de204a9a867"},{"title":"MeSH","uri":"D005762"}],"vocab":"health theme"},{"topic":"Paediatrics","extLink":[{"title":"ESV","uri":"http:\/\/data.europa.eu\/8mn\/euroscivoc\/bf8aaaac-ddee-41cd-bb8a-c5a63de3fcbd"},{"title":"MeSH","uri":"D010372"}],"vocab":"health theme"},{"topic":"Atresia of oesophagus","vocab":"cim-11","extLink":[{"title":"CIM-11","uri":"http:\/\/id.who.int\/icd\/entity\/1582061097"}]},{"topic":"Atresia of oesophagus without fistula","vocab":"cim-11","extLink":[{"title":"CIM-11","uri":"http:\/\/id.who.int\/icd\/entity\/338097604"}]},{"topic":"Atresia of oesophagus with tracheo-oesophageal fistula","vocab":"cim-11","extLink":[{"title":"CIM-11","uri":"http:\/\/id.who.int\/icd\/entity\/1902983254"}]},{"topic":"Long gap oesophageal atresia","vocab":"cim-11","extLink":[{"title":"CIM-11","uri":"http:\/\/id.who.int\/icd\/entity\/481037944"}]},{"topic":"Atresia of oesophagus with oesophagobronchial fistula","vocab":"cim-11","extLink":[{"title":"CIM-11","uri":"http:\/\/id.who.int\/icd\/entity\/1394325720"}]},{"topic":"Atresia of oesophagus with fistula between trachea and lower oesophageal pouch","vocab":"cim-11","extLink":[{"title":"CIM-11","uri":"http:\/\/id.who.int\/icd\/entity\/2094379240"}]},{"topic":"Atresia of oesophagus with fistula between trachea and upper oesophageal pouch","vocab":"cim-11","extLink":[{"title":"CIM-11","uri":"http:\/\/id.who.int\/icd\/entity\/1560464234"}]},{"topic":"Atresia of oesophagus with fistula between trachea and oesophageal pouch","vocab":"cim-11","extLink":[{"title":"CIM-11","uri":"http:\/\/id.who.int\/icd\/entity\/867594877"}]},{"topic":"Socio-demographic and economic determinants","vocab":"health determinant"},{"topic":"Socio-demographic and economic determinants: Gender","vocab":"health determinant"},{"topic":"Socio-demographic and economic determinants: Age","vocab":"health determinant"},{"topic":"Healthcare system determinants","vocab":"health determinant"},{"topic":"Healthcare system determinants: Use of care","vocab":"health determinant"},{"topic":"Behavioral determinants","vocab":"health determinant"},{"topic":"Behavioral determinants: Physical activity","vocab":"health determinant"},{"topic":"Behavioral determinants: Hygiene","vocab":"health determinant"},{"topic":"Biological determinants","vocab":"health determinant"},{"topic":"Biological determinants: Sex","vocab":"health determinant"},{"topic":"Other","vocab":"health determinant"},{"topic":"proteins, methylation, microRNA","vocab":"other determinant"}],"purpose":"2.1 Main Objective\r\n1. Assess the prevalence of gastroesophageal reflux (GERD) [pH\/impedance monitoring indicating pathological GERD and\/or if lesions of peptic esophagitis are observed during an endoscopy in the year prior to the visit, or if the child has a history of complicated GERD that led to anti-reflux surgery] during adolescence (ages 13\u201314) in children born with esophageal atresia\r\n\r\n2.2 Secondary Objectives\r\nThe study has several secondary objectives:\r\n1. Identify the factors measured throughout the patient\u2019s follow-up (at birth, 1 year, 6 years, and 13\u201314 years) that are associated with the prevalence of GERD in adolescence among children born with esophageal atresia\r\n2. Assessing quality of life, nutritional status, and the frequency of respiratory complications in adolescents who were born with esophageal atresia\r\n\r\nIn patients who underwent an esophageal biopsy at ages 10\u201314\r\n3. Analyze the omic and multi-omic profiles derived from esophageal biopsies in these patients during adolescence\u2014in comparison with a control group of adolescents without esophageal atresia\u2014to identify disruptions in biological pathways associated with esophageal atresia in patients who have had multiple biopsies since birth\r\n4. Examine changes in the expression levels of omic variables in the biological pathways identified in OS3 over time\r\n\r\nAmong patients who underwent blood tests and esophageal biopsies at ages 10\u201314 (a substudy conducted at centers in Lille, Paris Necker, Paris Robert Debr\u00e9, Lyon, Grenoble, and Marseille)\r\n5. To investigate the correlation between plasma levels of microRNAs or proteins and those measured in esophageal biopsies in relation to the omics variables identified in OS3.","abstract":"Esophageal atresia (EA), a congenital malformation of the esophagus present at birth, is characterized by a disruption in the continuity of the esophagus, which ends in a blind pouch. Food or saliva cannot pass into the stomach. It affects an average of 150 births per year in France, making it a rare condition.\r\n\r\nIt is therefore necessary to perform surgery to restore continuity of the esophagus. Although this procedure allows the vast majority of children to survive the neonatal period, health problems such as gastroesophageal reflux, difficulty eating, respiratory problems, and growth issues may persist throughout their lives.\r\n\r\nProject Objectives\r\nThe goal of the project is to establish a prospective cohort of 13- and 14-year-old adolescents, nested within the national esophageal atresia registry. In addition to clinical data, a biobank of esophageal mucosal and plasma samples will be established.\r\n\r\nOnce the clinical data have been collected and the omics data (derived from the analysis of biological samples from the biobank) have been generated, they will be analyzed by the project partners to assess the long-term course of EA and establish multi-omics profiles.","coll_dates":[{"start":"2024-08-30","end":"2026-10-10"}],"nation":[{"name":"France","abbreviation":"fr","extLink":{"vocab":"ISO","vocabURI":"fr"}}],"geog_coverage":"['Auvergne Rh\u00f4ne-Alpes','Bourgogne Franche-Comt\u00e9','Bretagne','Centre-Val de Loire','Corse','Grand Est','Guadeloupe','Hauts-de-France','Ile-de-France','La R\u00e9union','Martinique','Normandie','Nouvelle-Aquitaine','Occitanie','Pays de la Loire','Provence - Alpes - C\u00f4te d'Azur']","analysis_unit":"Individus","universe":"{\n    \"level_sex_clusion_I\": [\n        {\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"D005260\"\n            },\n            \"value\": \"Female\"\n        },\n        {\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"D008297\"\n            },\n            \"value\": \"Male\"\n        }\n    ],\n    \"level_age_clusion_I\": [\n        {\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"\"\n            },\n            \"value\": \"Prenatal\"\n        },\n        {\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"D007231\"\n            },\n            \"value\": \"Infant, Newborn (birth to 28 days)\"\n        },\n        {\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"D007223\"\n            },\n            \"value\": \"Infant (28 days to 2 years)\"\n        },\n        {\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"D002648\"\n            },\n            \"value\": \"Child (6 to 12 years)\"\n        },\n        {\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"D000293\"\n            },\n            \"value\": \"Adolescent (13 to 18 years)\"\n        }\n    ],\n    \"level_type_clusion_I\": \"Patients population\",\n    \"level_type_clusion_other\": \"\",\n    \"clusion_I\": \"For the EA group:\\r\\n- Born with esophageal atresia (EA) in France or in the French overseas departments and territories (DOM\\\/TOM)\\r\\n- Esophageal anastomosis performed\\r\\n- Must be 13 or 14 years old during the recruitment period (2023\u20132026)\\r\\n- Enrollment in the Renato Registry\\r\\n- Patient covered by social security\\r\\n- A patient willing to comply with all study procedures and to participate for the duration of the study\\r\\n\\r\\nFor the blood substudy:\\r\\n- Upper gastrointestinal endoscopy performed as part of medical care between the ages of 10 and 14, with a biopsy of the esophageal mucosa\\r\\n- Patient who has provided written consent to participate in the study (or in the ancillary study, if applicable, for the centers in Lille, Paris Necker, Paris Robert Debr\u00e9, Lyon, Marseille, and Grenoble)\\r\\n\\r\\n\\r\\nFor the control group:\\r\\n- Upper gastrointestinal endoscopy performed between the ages of 10 and 14, with a biopsy of the esophageal mucosa\\r\\n- Upper gastrointestinal endoscopy performed as part of the management of chronic or acute gastrointestinal symptoms to rule out an organic cause (peptic esophagitis, gastric esophagitis, eosinophilic esophagitis or ulcer)\\r\\n- Normal endoscopy and histology\\r\\n- No concurrent progressive chronic disease\",\n    \"clusion_E\": \"Exclusion Criteria\\r\\n\\r\\nFor the EA group:\\r\\n- Concurrent participation in an interventional trial as well as within 3\\r\\nthe month prior to inclusion\\r\\n- Parents who refuse to participate in the study\\r\\n\\r\\nFor the control group:\\r\\n- Esophageal biopsy with histologically abnormal findings\\r\\n- Parents who refuse to participate in the study\\r\\n- Child with a known organic condition\"\n}","data_kind":"['Clinical data','Biological data','Socio-demographic data','Economic data','Other']","quality_statement":{"standards":[{"name":"","committee":"Steering Committee and Scientific Advisory Board","governance":""}],"other_quality_statement":""}},"study_development":{"development_activity":[{"activity_type":"primary evaluation","activity_description":"GERD will be suspected in the presence of suggestive symptoms such as regurgitation and heartburn. The diagnosis will be confirmed if, within the year prior to the visit, a pH\/impedance study reveals pathological GERD and\/or if lesions of peptic esophagitis are observed during endoscopy, or if the child has a history of complicated GERD that led to anti-reflux surgery. GERD will be considered absent in the absence of clinical signs of GERD (regurgitation, heartburn) and if the most recent pH\/impedance monitoring performed without treatment as part of follow-up does not reveal pathological GERD."},{"activity_type":"secondary evaluation","activity_description":"Assignment No. 1:\r\nVariable to be explained (dependent variable): the prevalence of GERD at ages 13\u201314\r\nExplanatory (independent) variables: These will be identified from the patients\u2019 characteristics at birth, at 1 year, 6 years, and 13\u201314 years of age (prenatal data, vital signs, presence of associated malformations, type of atresia, surgical procedures performed, surgical\/gastrointestinal\/respiratory\/neuroorthopedic complications, feeding method, and educational attainment).\r\n\r\nOS No. 2:\r\n- The quality of life of adolescent patients will be assessed by administering the following quality-of-life scales when the patients are 13\u201314 years old: PedsQL and EA-QoL, to be completed by both the patient and a parent. The scale scores will be calculated in accordance with the authors\u2019 administration guidelines.\r\n- Nutritional status will be assessed based on weight and height, as well as by calculating the weight-for-height z-score and BMI z-score, using the World Health Organization\u2019s growth charts as a reference.\r\n- Frequency of respiratory complications, as assessed during the clinical examination (hoarse cough during infections, chronic cough, asthma, exercise-induced symptoms [cough, dyspnea], atopy, wheezing, and\/or stridor).\r\n\r\nOS No. 3\r\nMeasured variables: transcripts, metabolites, proteins, and methylation\r\nVariables to be explained (dependent variables): EA diagnosis (yes\/no)\r\nThe affected metabolic pathways will be identified through enrichment analysis based on the markers that are dysregulated between the group with EA and the group without EA.\r\n\r\nOS No. 4:\r\nMeasured variables: transcripts, metabolites, proteins, and methylation\r\nAnalysis of the difference in means between the levels of the measured variables at different time points\r\n\r\nOS No. 5:\r\nVariables measured in plasma: expression levels of microRNAs or proteins\r\nVariables measured in esophageal biopsies: expression levels of microRNAs or proteins. The statistical unit will be the omic variable (microRNA or protein), and the correlation will be calculated between the measurements in plasma and the corresponding measurements in the biopsies."}]},"method":{"data_collection":{"time_method":"Other","frequency":"Once","sampling_procedure":"['{\"concept\":{\"vocab\":\"CESSDA\",\"vocabURI\":\"TotalUniverseCompleteEnumeration\"},\"value\":\"Complete enumeration (including consecutive recruitment)\"}']","sample_frame":{"frame_unit":{"unit_type":"['Disease and death registry']"}},"coll_mode":["{\"concept\":{\"vocab\":\"CESSDA\",\"vocabURI\":\"Interview\"},\"value\":\"Interview with the participant (including clinical)\"}","{\"concept\":{\"vocab\":\"CESSDA\",\"vocabURI\":\"MeasurementsAndTests\"},\"value\":\"Measurements and tests\"}","{\"concept\":{\"vocab\":\"CESSDA\",\"vocabURI\":\"MeasurementsAndTests.Physical\"},\"value\":\"Physical\/biological measurements (blood pressure, weight, biochemistry, imaging, etc.)\"}","{\"concept\":{\"vocab\":\"CESSDA\",\"vocabURI\":\"MeasurementsAndTests.Psychological\"},\"value\":\"Psychological tests\/clinical scales (depression, cognition, quality of life, etc.)\"}","{\"concept\":{\"vocab\":\"CESSDA\",\"vocabURI\":\"Observation\"},\"value\":\"Observation (clinical or behavioural)\"}","{\"concept\":{\"vocab\":\"CESSDA\",\"vocabURI\":\"SelfAdministeredQuestionnaire\"},\"value\":\"Self-administered questionnaire\"}"],"research_instrument":"","sources":[{"sourceCitation":{"titlStmt":{"titl":"National Registry of Patients Born with Esophageal Atresia in France"},"holdings":"ReNAtO","notes":{"subject":"source purpose","value":"Data enrichment through cross-referencing"}},"srcOrig":["Registry"]}],"target_sample_size":"< 500 individuals","response_rate":"413"},"method_notes":"Observational Study","study_class":"Ongoing study","notes":[{"subject":"research type","values":["Observational Study"]},{"subject":"observational study method","values":["Cohort study"]}]},"data_access":{"dataset_availability":{"access_place":"","complete":"","status":"{\"extLink\":{\"title\":\"COAR\",\"uri\":\"\"},\"value\":\"To be defined\"}","notes":""},"dataset_use":{"restrictions":"","conditions":"","conf_dec":[{"txt":""}],"spec_perm":[{"txt":"","required":""}],"contact":[{"name":"M\u00e9lanie;LEROY","firstname":"M\u00e9lanie","lastname":"LEROY","email":"melanie.leroy@chu-lille.fr"}],"deposit_req":"","cit_req":""}}},"additional":{"versionLang":"en","originLang":"en","lastUpdatedAuto":"01-10-2026","lastUpdatedManual":"01-10-2026","autoTranslation":false,"status":"Published","respValidation":"","isHealthTheme":true,"isContributorPI":false,"addTeamMember":true,"primaryInvestigator":{"isPIContact":false,"piMail":"frederic.gottrand@chu-lille.fr","piAffiliation":{"piLabo":"Department of Pediatric Gastroenterology, Hepatology, and Nutrition\r\nReference Center for Chronic Diseases and Esophageal Malformations (CRACMO)"}},"relatedDocument":[{"type":"Publication defining the database and\/or its collection protocol  (data paper, cohort profile, method\/protocol paper, resource paper, data note, registered report...)","title":"Long-term Outcomes of Esophageal Atresia in Adolescence (TransEAsome): A National French Cohort Study Protocol","link":"https:\/\/hal.science\/hal-04887829v1"}],"contactPointLabo":"Kids France","obtainedAuthorization":{"otherAuthorizingAgency":["",""]},"regulatoryRequirements":{"conformityDeclaration":""},"fundingAgent":{"fundingAgentType":["Public (France)"],"otherFundingAgentType":[""]},"sponsor":{"sponsorType":["Public (France)"],"otherSponsorType":[""]},"governance":{"committee":true},"collaborations":{"networkConsortium":true},"theme":{"complementaryInformation":"","RareDiseases":true},"interventionalStudy":{"researchPurpose":[],"trialPhase":[],"interventionalStudyModel":"","isClinicalTrial":"","otherResearchPurpose":""},"isInclusionGroups":true,"allocation":{"allocationMode":"","allocationUnit":""},"masking":{"maskingType":"","blindedMaskingDetails":[]},"arms":[],"intervention":[{"name":"None","type":"","typeOther":""}],"cohortLongitudinal":{"recrutementTiming":[]},"otherResearchType":{"otherResearchTypeDetails":""},"inclusionGroups":[{"name":"Patient","description":""},{"name":"Control","description":""}],"nrInclusionGroups":false,"collectionProcess":{"collectionModeDetails":"The TransEAsome project is a nested cohort within the ReNAtO registry (the national registry of patients born with esophageal atresia). The data collected in TransEAsome are linked to the registry data (at birth and at 1 year of age).","collectionModeOther":""},"dataCollection":{"inclusionStrategy":[],"samplingModeOther":"","recruitmentSourceOther":"","otherDocumentation":""},"activeFollowUp":{"isActiveFollowUp":false,"followUpModeOther":""},"dataCollectionIntegration":{"isDataIntegration":true},"geographicalCoverage":{"geoDetail":""},"dataTypes":{"clinicalDataDetails":"Presentation on gastroenterology, pulmonology, neuro-orthopedics, and speech therapy","biologicalDataDetails":"omics","isDataInBiobank":false,"biobankContent":[],"biobankContentOther":"","dataTypeOther":"quality of life","paraclinicalDataOther":"","otherLiquidsDetails":""},"variableDictionnary":{"variableDictionnaryAvailable":true,"variableDictionnaryLink":""},"dataQuality":{"otherDocumentation":""},"mockSample":{"mockSampleLocation":""},"thirdPartySource":{"otherSourceType":[""]},"fileDscr":{"fileTxt":{"fileCitation":{"titlStmt":{"IDno":[]}}}}},"schematype":"survey"}