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Asthma and Airway Obstruction Cohort: Clinicobiological Cohort Follow-up

France, 2008 - 2018
Reference ID
FRESH-PEF60115-en
Producer(s)
Michel;AUBIER
Metadata
DDI/XML JSON
Study website Interactive tools
Created on
Feb 18, 2026
Last modified
Feb 18, 2026
Page views
41
  • Identification
  • Scope
  • Coverage
  • Producers and sponsors
  • Study authorization
  • Sampling
  • Survey instrument
  • Data collection
  • Study activities
  • Data Access
  • Contacts

    • Identification

    Survey ID number

    FRESH-PEF60115-en
    Title

    Asthma and Airway Obstruction Cohort: Clinicobiological Cohort Follow-up
    Abbreviation or Acronym

    COBRA
    Country
    Name Country code
    France fr
    Kind of Data

    ['Clinical data','Paraclinical data (non-biological)','Paraclinical data (non-biological) : Imaging','Biological data','Participant-reported health data']
    Unit of Analysis

    Individuals

    Scope

    Topics
    Topic Vocabulary
    Pulmonary medicine health theme
    Environmental determinants: Climate health determinant
    Environmental determinants health determinant
    Keywords
    Health episodes severity

    Coverage

    Universe

    {"level_sex_clusion_I":[{"value":"Male","concept":{"vocab":"MeSH","vocabURI":"D008297"}},{"value":"Female","concept":{"vocab":"MeSH","vocabURI":"D005260"}}],"level_age_clusion_I":[{"value":"Young Adult (19 to 24 years)","concept":{"vocab":"MeSH","vocabURI":"D055815"}},{"value":"Adult (25 to 44 years)","concept":{"vocab":"MeSH","vocabURI":"D000328"}},{"value":"Middle Aged (45 to 64 years)","concept":{"vocab":"MeSH","vocabURI":"D008875"}},{"value":"Aged (65 to 79 years)","concept":{"vocab":"MeSH","vocabURI":"D000368"}}],"level_type_clusion_I":"Patients population","level_type_clusion_other":"","clusion_I":"Two cohorts: one with asthmatics and one with individuals affected by COBP; subjects included between the ages of 18 and 80 years old. Asthma cohort: including patients who are non-smokers and smokers with compatible clinical history and individuals with a reversible obstructive airway disease, based on a FEV1/CV <75% and an FEV1 baseline value improvement of 12% or 200 ml after inhalation of 400 µg of Salbutamol. COBP cohort: including patients who are smokers (>10 packets per year) presenting with an obstructive airway disease (FEV1/CV <75%) and an FEV1 improvement of less than 10% after inhalation of 200 µg of Salbutamol.","clusion_E":""}

    Producers and sponsors

    Primary investigators
    Name
    Michel;AUBIER
    Producers
    Name Role
    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) sponsor
    Funding Agency/Sponsor
    Name
    ASTRAZENECA (FRANCE)
    CENTRE HOSPITALIER UNIVERSITAIRE DE NIMES (CHU)
    CHIESI (FRANCE)
    GLAXOSMITHKLINE (FRANCE)
    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

    Study authorization

    Agency
    Agency name
    CNIL

    Sampling

    Sample frame

    Unit Type

    ['Through organizations (health services or institutions, schools, businesses, etc.)']
    Sampling Procedure

    ['{"concept":{"vocabURI":"Other","vocab":"CESSDA"},"value":"Other"}']

    Survey instrument

    Questionnaires

    Access on specific project only
    Methodology notes

    Observational Study

    Data collection

    Dates of Data Collection
    Start End
    2008-01-01 2018-01-01
    Mode of data collection
    • {"concept":{"vocabURI":"SelfAdministeredQuestionnaire","vocab":"CESSDA"},"value":"Self-administered questionnaire"}
    • {"concept":{"vocabURI":"Interview","vocab":"CESSDA"},"value":"Interview with the participant (including clinical)"}

    Study activities

    Study activities
    Type
    primary evaluation
    Description
    Health event/morbidity Health event/mortality Quality of life/health perception

    Data Access

    Access conditions

    Contractual access subject to COBRA Scientific Council validation. Research projects that can use clinical and/or biological cohort data are encouraged and validated by the Scientific Council (2 members per centre).
    Availability Status

    {"value":"Restricted access","extLink":[{"title":"COAR","uri":"http://purl.org/coar/access_right/c_16ec"}]}
    Restrictions

    Data may be used by academic teams. Data may not be used by industrial teams.

    Contacts

    Contacts
    Name Email
    Michel;AUBIER michel.aubier@wanadoo.fr
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