{"doc_desc":{"title":"\u00c9tude \u00c9pid\u00e9miologique aupr\u00e8s de femmes de la Mutuelle G\u00e9n\u00e9rale de l\u2019\u00c9ducation Nationale et des membres de leur famille","idno":"FRESH-PEF3101-fr","producers":[{"name":"CAMILLE LAPLANCHE","affiliation":""}]},"study_desc":{"title_statement":{"idno":"FRESH-PEF3101-fr","IDno":{"metadata_no":[{"agency":"PORTAIL EPIDEMIOLOGIE FRANCE (PEF)","code":"3101"},{"agency":"FReSH","code":"FRESH-PEF3101"}],"metadata_yes":[{"code":"FReSH","agency":"FReSH"}]},"title":"\u00c9tude \u00c9pid\u00e9miologique aupr\u00e8s de femmes de la Mutuelle G\u00e9n\u00e9rale de l\u2019\u00c9ducation Nationale et des membres de leur famille","alternate_title":"Cohorte E3N-G\u00e9n\u00e9rations"},"study_authorization":{"agency":[{"name":"CNIL"},{"name":"CPP"}]},"authoring_entity":[{"name":"Gianluca;SEVERI","firstname":"Gianluca","lastname":"SEVERI","type":"investigator","extlink":[{"title":"ORCID","uri":"0000-0001-7157-419X","role":"pi id"},{"title":"IdRef","uri":"198040598","role":"pi id"},{"title":"ROR","uri":"https:\/\/ror.org\/02vjkv261","role":"organisation id"},{"title":"SIREN","uri":"180036048","role":"organisation id"},{"title":"RNSR","uri":"201019083D","role":"labo id"}],"email":"gianluca.severi@inserm.fr","affiliationName":"INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)","PILabo":"Centre de recherche en \u00c9pid\u00e9miologie et Sant\u00e9 des Populations (CESP), \u00e9quipe Exposome et H\u00e9r\u00e9dit\u00e9","isContact":false}],"oth_id":[{"name":";","firstname":"","lastname":"","type":"contributor","isContact":"","extlink":[{"title":"ORCID","uri":"","role":"team member id"},{"title":"IdRef","uri":"","role":"team member id"}]},{"name":"","type":"affiliation","teamMemberLabo":"","extlink":[{"title":"RNSR","uri":"","role":"labo id"}]},{"name":"La cohorte europ\u00e9enne EPIC (European Prospective Investigation into Cancer and Nutrition), dont la partie fran\u00e7aise est repr\u00e9sent\u00e9e par les femmes de la premi\u00e8re g\u00e9n\u00e9ration de la cohorte E3N-G\u00e9n\u00e9rations. Les consortia ELAPSE, EPITHYR, LIFEPATH et ESCAPE utilisent \u00e9galement des donn\u00e9es des femmes G1. Les donn\u00e9es de la cohorte (Femmes G1, Hommes G1 et G2) sont utilis\u00e9es dans les \u00e9tudes nationales SAPRIS et SAPRIS-SERO sur le covid-19.","type":"collaboration"}],"production_statement":{"prod_place":"Portail Epid\u00e9miologie France (PEF)","producers":[{"name":"INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)","role":"sponsor","extlink":[{"title":"SIREN","uri":"180036048","role":"sponsor id"},{"title":"ROR","uri":"https:\/\/ror.org\/02vjkv261","role":"sponsor id"}]},{"name":"INSTITUT GUSTAVE ROUSSY (IGR)","role":"sponsor","extlink":[{"title":"SIREN","uri":"775741101","role":"sponsor id"},{"title":"ROR","uri":"https:\/\/ror.org\/0321g0743","role":"sponsor id"}]},{"name":"UNIVERSITE PARIS-SACLAY","role":"sponsor","extlink":[{"title":"ROR","uri":"https:\/\/ror.org\/03xjwb503","role":"sponsor id"},{"title":"SIREN","uri":"130026024","role":"sponsor id"}]}],"funding_agencies":[{"name":"AGENCE NATIONALE DE LA RECHERCHE (ANR)","extlink":[{"title":"ROR","uri":"https:\/\/ror.org\/00rbzpz17"},{"title":"SIREN","uri":"130002504"}]},{"name":"MINISTERE DE L\u2019ENSEIGNEMENT SUPERIEUR, DE LA RECHERCHE ET DE L\u2019ESPACE","extlink":[{"title":"SIREN","uri":"110044013"},{"title":"ROR","uri":"https:\/\/ror.org\/03sjk9a61"}]},{"name":"INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)","extlink":[{"title":"SIREN","uri":"180036048"},{"title":"ROR","uri":"https:\/\/ror.org\/02vjkv261"}]},{"name":"INSTITUT GUSTAVE ROUSSY (IGR)","extlink":[{"title":"SIREN","uri":"775741101"},{"title":"ROR","uri":"https:\/\/ror.org\/0321g0743"}]},{"name":"LIGUE NATIONALE CONTRE LE CANCER (LNCC)","extlink":[{"title":"SIREN","uri":"775664717"},{"title":"ROR","uri":"https:\/\/ror.org\/00rkrv905"}]},{"name":"MGEN"},{"name":"UNIVERSITE PARIS-SACLAY","extlink":[{"title":"SIREN","uri":"130026024"},{"title":"ROR","uri":"https:\/\/ror.org\/03xjwb503"}]}]},"distribution_statement":{"contact":[{"name":"Elodie;SPEYER","lastname":"SPEYER","firstname":"Elodie","type":"contact","email":"elodie.speyer@inserm.fr","affiliationName":"UNIVERSITE PARIS-SACLAY","contactPointLabo":"Centre de recherche en \u00c9pid\u00e9miologie et Sant\u00e9 des Populations (CESP), \u00e9quipe Exposome et H\u00e9r\u00e9dit\u00e9","extlink":[{"title":"SIREN","uri":"130026024","role":"organisation id"},{"title":"ROR","uri":"https:\/\/ror.org\/03xjwb503","role":"organisation id"},{"title":"RNSR","uri":"201019083D","role":"labo id"}]},{"name":"CAMILLE;LAPLANCHE","lastname":"LAPLANCHE","firstname":"CAMILLE","type":"contact","email":"camille.laplanche@gustaveroussy.fr","affiliationName":"UNIVERSITE PARIS-SACLAY","contactPointLabo":"Centre de recherche en \u00c9pid\u00e9miologie et Sant\u00e9 des Populations (CESP), \u00e9quipe Exposome et H\u00e9r\u00e9dit\u00e9","extlink":[{"title":"SIREN","uri":"130026024","role":"organisation id"},{"title":"ROR","uri":"https:\/\/ror.org\/03xjwb503","role":"organisation id"},{"title":"RNSR","uri":"201019083D","role":"labo id"}]}]},"study_info":{"keywords":[{"keyword":"Famille"},{"keyword":"mode de vie"},{"keyword":"exposome"},{"keyword":"alimentation"},{"keyword":"marqueurs biologiques"},{"keyword":"g\u00e9n\u00e9tique"},{"keyword":"vieillissement"},{"keyword":"environnement"},{"keyword":"pharmaco-\u00e9pid\u00e9miologie"}],"topics":[{"topic":"Tumeurs malignes du sein","vocab":"cim-11","extLink":[{"title":"CIM-11","uri":"http:\/\/id.who.int\/icd\/entity\/1047754165"}]},{"topic":"Tumeurs malignes du c\u00f4lon","vocab":"cim-11","extLink":[{"title":"CIM-11","uri":"http:\/\/id.who.int\/icd\/entity\/1265576634"}]},{"topic":"Tumeurs malignes du col ut\u00e9rin","vocab":"cim-11","extLink":[{"title":"CIM-11","uri":"http:\/\/id.who.int\/icd\/entity\/1256072522"}]},{"topic":"Asthme","vocab":"cim-11","extLink":[{"title":"CIM-11","uri":"http:\/\/id.who.int\/icd\/entity\/1656445230"}]},{"topic":"Maladie de Parkinson","vocab":"cim-11","extLink":[{"title":"CIM-11","uri":"http:\/\/id.who.int\/icd\/entity\/296066191"}]},{"topic":"Tumeurs malignes de la prostate","vocab":"cim-11","extLink":[{"title":"CIM-11","uri":"http:\/\/id.who.int\/icd\/entity\/1552457716"}]},{"topic":"Cancer du poumon","vocab":"cim-11","extLink":[{"title":"CIM-11","uri":"http:\/\/id.who.int\/icd\/entity\/1679532614"}]},{"topic":"Endom\u00e9triose","vocab":"cim-11","extLink":[{"title":"CIM-11","uri":"http:\/\/id.who.int\/icd\/entity\/1838213761"}]},{"topic":"Diab\u00e8te sucr\u00e9 de type 2","vocab":"cim-11","extLink":[{"title":"CIM-11","uri":"http:\/\/id.who.int\/icd\/entity\/119724091"}]},{"topic":"Maladies de l'appareil circulatoire","vocab":"cim-11","extLink":[{"title":"CIM-11","uri":"http:\/\/id.who.int\/icd\/entity\/426429380"}]},{"topic":"Psoriasis","vocab":"cim-11","extLink":[{"title":"CIM-11","uri":"http:\/\/id.who.int\/icd\/entity\/63698555"}]},{"topic":"Tumeurs malignes de l'ovaire","vocab":"cim-11","extLink":[{"title":"CIM-11","uri":"http:\/\/id.who.int\/icd\/entity\/685124533"}]},{"topic":"Lymphomes de Hodgkin et non Hodgkiniens","vocab":"cim-11","extLink":[{"title":"CIM-11","uri":"http:\/\/id.who.int\/icd\/entity\/1891884932"}]},{"topic":"M\u00e9lanome de la peau","vocab":"cim-11","extLink":[{"title":"CIM-11","uri":"http:\/\/id.who.int\/icd\/entity\/488336723"}]},{"topic":"Tumeurs malignes de la peau","vocab":"cim-11","extLink":[{"title":"CIM-11","uri":"http:\/\/id.who.int\/icd\/entity\/1706880799"}]},{"topic":"D\u00e9clin cognitif li\u00e9 \u00e0 l'\u00e2ge","vocab":"cim-11","extLink":[{"title":"CIM-11","uri":"http:\/\/id.who.int\/icd\/entity\/584231559"}]},{"topic":"D\u00e9pression (MT1)","vocab":"cim-11","extLink":[{"title":"CIM-11","uri":"http:\/\/id.who.int\/icd\/entity\/480354492"}]},{"topic":"Hypertension essentielle","vocab":"cim-11","extLink":[{"title":"CIM-11","uri":"http:\/\/id.who.int\/icd\/entity\/761947693"}]},{"topic":"Tumeur maligne du pancr\u00e9as","vocab":"cim-11","extLink":[{"title":"CIM-11","uri":"http:\/\/id.who.int\/icd\/entity\/542147910"}]},{"topic":"Cancer des voies respiratoires","vocab":"cim-11","extLink":[{"title":"CIM-11","uri":"http:\/\/id.who.int\/icd\/entity\/693315837"}]},{"topic":"Tumeurs malignes du rectum","vocab":"cim-11","extLink":[{"title":"CIM-11","uri":"http:\/\/id.who.int\/icd\/entity\/1113099195"}]},{"topic":"Tumeurs malignes de la glande thyro\u00efde","vocab":"cim-11","extLink":[{"title":"CIM-11","uri":"http:\/\/id.who.int\/icd\/entity\/447433352"}]},{"topic":"Polyarthrite rhumato\u00efde","vocab":"cim-11","extLink":[{"title":"CIM-11","uri":"http:\/\/id.who.int\/icd\/entity\/576319925"}]},{"topic":"Tumeurs malignes de l'estomac","vocab":"cim-11","extLink":[{"title":"CIM-11","uri":"http:\/\/id.who.int\/icd\/entity\/1397617262"}]},{"topic":"D\u00e9g\u00e9n\u00e9rescence maculaire li\u00e9e \u00e0 l'\u00e2ge","vocab":"cim-11","extLink":[{"title":"CIM-11","uri":"http:\/\/id.who.int\/icd\/entity\/1514301548"}]},{"topic":"COVID-19","vocab":"cim-11","extLink":[{"title":"CIM-11","uri":"http:\/\/id.who.int\/icd\/entity\/1730556128"}]},{"topic":"SRAS-CoV-2","vocab":"cim-11","extLink":[{"title":"CIM-11","uri":"http:\/\/id.who.int\/icd\/entity\/243015485"}]},{"topic":"D\u00e9terminants socio-d\u00e9mographiques et \u00e9conomiques","vocab":"health determinant"},{"topic":"D\u00e9terminants socio-d\u00e9mographiques et \u00e9conomiques : Emploi","vocab":"health determinant"},{"topic":"D\u00e9terminants socio-d\u00e9mographiques et \u00e9conomiques : Revenu","vocab":"health determinant"},{"topic":"D\u00e9terminants socio-d\u00e9mographiques et \u00e9conomiques : Niveau d'\u00e9tudes","vocab":"health determinant"},{"topic":"D\u00e9terminants socio-d\u00e9mographiques et \u00e9conomiques : \u00c2ge","vocab":"health determinant"},{"topic":"D\u00e9terminants environnementaux","vocab":"health determinant"},{"topic":"D\u00e9terminants environnementaux : Qualit\u00e9 de l'air","vocab":"health determinant"},{"topic":"D\u00e9terminants environnementaux : Climat","vocab":"health determinant"},{"topic":"D\u00e9terminants environnementaux : Autre","vocab":"health determinant"},{"topic":"D\u00e9terminants li\u00e9s au syst\u00e8me de sant\u00e9","vocab":"health determinant"},{"topic":"D\u00e9terminants li\u00e9s au syst\u00e8me de sant\u00e9 : Consommation des soins","vocab":"health determinant"},{"topic":"D\u00e9terminants comportementaux","vocab":"health determinant"},{"topic":"D\u00e9terminants comportementaux : Alimentation","vocab":"health determinant"},{"topic":"D\u00e9terminants comportementaux : Activit\u00e9 physique","vocab":"health determinant"},{"topic":"D\u00e9terminants biologiques","vocab":"health determinant"},{"topic":"D\u00e9terminants biologiques : Pr\u00e9disposition g\u00e9n\u00e9tique","vocab":"health determinant"},{"topic":"D\u00e9terminants biologiques : Viellissement","vocab":"health determinant"},{"topic":"D\u00e9terminants biologiques : Sexe","vocab":"health determinant"},{"topic":"contaminants alimentaires, polluants \u00e9ternels, pollution sonore, lumi\u00e8re artificielle la nuit","vocab":"other environmental determinant"}],"purpose":"L\u2019objectif de la cohorte familiale E3N-G\u00e9n\u00e9rations est de mieux comprendre, dans l\u2019apparition des maladies, ce qui rel\u00e8ve de la g\u00e9n\u00e9tique, du mode de vie et de l\u2019environnement. En plus d'un grand nombre de donn\u00e9es \u00e9pid\u00e9miologiques prospectives, la cohorte E3N-G\u00e9n\u00e9rations collecte de pr\u00e9cieuses informations ph\u00e9notypiques, biologiques et g\u00e9n\u00e9tiques.","abstract":"L'\u00e9tude familiale E3N-G\u00e9n\u00e9rations a pour but d'\u00e9tudier la sant\u00e9 en relation avec le mode de vie moderne chez des personnes d'une m\u00eame famille, sur trois g\u00e9n\u00e9rations. L\u2019\u00e9tude E3N-G\u00e9n\u00e9rations prolonge l\u2019\u00e9tude E3N en suivant les membres de la famille des femmes ayant particip\u00e9 \u00e0 la cohorte E3N : les p\u00e8res de leurs enfants, leurs enfants et leurs petits-enfants. \r\n\r\nsite web de l'\u00e9tude : www.e3n-generations.fr","coll_dates":[{"start":"1990-01-01"}],"nation":[{"name":"France","abbreviation":"fr","extLink":{"vocab":"ISO","vocabURI":"fr"}}],"geog_coverage":"","analysis_unit":"Individus","universe":"{\n    \"level_sex_clusion_I\": [\n        {\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"D005260\"\n            },\n            \"value\": \"F\u00e9minin\"\n        },\n        {\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"D008297\"\n            },\n            \"value\": \"Masculin\"\n        }\n    ],\n    \"level_age_clusion_I\": [\n        {\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"D055815\"\n            },\n            \"value\": \"Adulte (19 \u00e0 24 ans)\"\n        },\n        {\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"D000328\"\n            },\n            \"value\": \"Adulte (25 \u00e0 44 ans)\"\n        },\n        {\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"D008875\"\n            },\n            \"value\": \"Adulte (45 \u00e0 64 ans)\"\n        },\n        {\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"D000368\"\n            },\n            \"value\": \"Personne \u00e2g\u00e9e (65 \u00e0 79 ans)\"\n        },\n        {\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"D000369\"\n            },\n            \"value\": \"Grand \u00e2ge (80 ans et plus)\"\n        }\n    ],\n    \"level_type_clusion_I\": \"Population g\u00e9n\u00e9rale\",\n    \"level_type_clusion_other\": \"\",\n    \"clusion_I\": \"Femmes de la cohorte E3N (Femmes G1) : 98 995 femmes fran\u00e7aises r\u00e9sidant en France m\u00e9tropolitaine en 1990, n\u00e9es entre 1925 et 1950 et affili\u00e9es \u00e0 la MGEN.\\r\\nP\u00e8res des enfants des femmes G1 (Hommes G1) \\r\\nFils et filles des femmes G1 ( G\u00e9n\u00e9ration 2 dite G2) \\r\\nPetits-enfants des femmes G1 (G\u00e9n\u00e9ration 3 dite G3)\",\n    \"clusion_E\": \"\"\n}","data_kind":"['Donn\u00e9es cliniques','Donn\u00e9es biologiques','Donn\u00e9es socio-d\u00e9mographiques','Donn\u00e9es environnementales \/ d'exposition','Donn\u00e9es comportementales','Donn\u00e9es g\u00e9ospatiales','Donn\u00e9es \u00e9conomiques','Donn\u00e9es g\u00e9n\u00e9tiques \/ g\u00e9nomiques','Donn\u00e9es de sant\u00e9 rapport\u00e9es par les participants de l'\u00e9tude']","quality_statement":{"standards":[{"name":"['CIM 10']","committee":"Le comit\u00e9 institutionnel r\u00e9unit les partenaires fondateurs : Universit\u00e9 Paris-Saclay, Inserm, Gustave Roussy, Ligue Nationale contre le Cancer et la MGEN. Il a pour missions principales de valider les orientations strat\u00e9giques, suivre l'avancement de la cohorte et sa situation budg\u00e9taire \/ approuver la gestion budg\u00e9taire, les comptes et les rapports annuels d\u2019activit\u00e9 \/ pr\u00e9voir les modalit\u00e9s d'\u00e9valuation de la cohorte et d\u00e9cider son \u00e9ventuelle interruption ou sa prorogation \/ adopter une Charte d\u2019acc\u00e8s aux donn\u00e9es et aux \u00e9chantillons de la cohorte. Le conseil scientifique, compos\u00e9 d'experts internationaux, veille quant \u00e0 lui \u00e0 la pertinence et \u00e0 la qualit\u00e9 scientifique des recherches r\u00e9alis\u00e9es \u00e0 partir des donn\u00e9es et des \u00e9chantillons de la cohorte ; il incite \u00e0 des collaborations en recensant les comp\u00e9tences et les savoirs-faire, et il donne un avis sur la Charte d'acc\u00e8s aux donn\u00e9es.","governance":""}],"other_quality_statement":"['Validation des pathologies par une \u00e9quipe d'ARC qui s'appuient sur les documents m\u00e9dicaux des participants pour valider les pathologies d\u00e9clar\u00e9es.']"}},"study_development":{"development_activity":[{"activity_type":"primary evaluation","activity_description":"Ev\u00e9nements de sant\u00e9\/morbidit\u00e9\r\nEv\u00e9nements de sant\u00e9\/mortalit\u00e9\r\nConsommation de soins\/services de sant\u00e9\r\nQualit\u00e9 de vie\/sant\u00e9 per\u00e7ue"},{"activity_type":"secondary evaluation","activity_description":""}]},"method":{"data_collection":{"time_method":"Longitudinale prospective","frequency":"Tous les deux ans environ","sampling_procedure":"['{\"concept\":{\"vocab\":\"CESSDA\",\"vocabURI\":\"Other\"},\"value\":\"Autre\"}']","sample_frame":{"frame_unit":{"unit_type":"['Autre']"}},"coll_mode":["{\"concept\":{\"vocab\":\"CESSDA\",\"vocabURI\":\"SelfAdministeredQuestionnaire\"},\"value\":\"Questionnaire auto-administr\u00e9\"}"],"research_instrument":"Acc\u00e8s restreint sur projet sp\u00e9cifique","sources":[{"sourceCitation":{"titlStmt":{"titl":"Base de remboursement de soins de la MGEN (pour les femmes G1 uniquement)"},"holdings":"","notes":{"subject":"source purpose","value":"Enrichissement des donn\u00e9es par croisement (autre que le suivi passif)"}},"srcOrig":["Base m\u00e9dico-administrative"]},{"sourceCitation":{"titlStmt":{"titl":"CepiDC"},"holdings":"","notes":{"subject":"source purpose","value":"Suivi passif des participants"}},"srcOrig":["Base m\u00e9dico-administrative"]}],"target_sample_size":">= 20000 individus","response_rate":"98 995 G1 Women ; 17 700 G1 Men ; 21 000 G2"},"method_notes":"Etude observationnelle","study_class":"\u00c9tude en cours","notes":[{"subject":"research type","values":["Etude observationnelle"]},{"subject":"observational study method","values":["Cohorte"]},{"subject":"follow-up","values":["Suivi par contact avec le participant (t\u00e9l\u00e9phone, e-mail, courrier...)"]}]},"data_access":{"dataset_availability":{"access_place":"Pour les G1 : Les donn\u00e9es collect\u00e9es sont stock\u00e9es sur des serveurs s\u00e9curis\u00e9s agr\u00e9\u00e9s pour l'h\u00e9bergement des donn\u00e9es de sant\u00e9, \u00e0 Gustave Roussy, et b\u00e9n\u00e9ficient de tous les outils de protection de l\u2019h\u00f4pital, qui g\u00e8re en permanence des donn\u00e9es m\u00e9dicales sensibles. Pour les G2 : Les donn\u00e9es brutes sont recueillies sur la plateforme de web-questionnaires (d\u00e9velopp\u00e9e par la soci\u00e9t\u00e9 Gide) sont h\u00e9berg\u00e9es sur des serveurs certifi\u00e9s pour l'h\u00e9bergement de donn\u00e9es de sant\u00e9. Puis les donn\u00e9es g\u00e9n\u00e9r\u00e9es sont stock\u00e9es comme celles des G1, sur des serveurs s\u00e9curis\u00e9s agr\u00e9\u00e9s HDS de Gustave Roussy.","complete":"","status":"{\"extLink\":{\"title\":\"COAR\",\"uri\":\"http:\/\/purl.org\/coar\/access_right\/c_16ec\"},\"value\":\"Acc\u00e8s r\u00e9serv\u00e9\"}"},"dataset_use":{"restrictions":"","conditions":"Modalit\u00e9s d'acc\u00e8s aux donn\u00e9es pour des \u00e9quipes ext\u00e9rieures : demande d'autorisation au comit\u00e9 d'acc\u00e8s aux donn\u00e9es de la cohorte E3N-G\u00e9n\u00e9rations","conf_dec":[{"txt":"Charte d'acc\u00e8s aux donn\u00e9es"}],"spec_perm":[{"txt":"https:\/\/demande-acces-donnees.portail-fresh.fr\/signin ","required":"Oui"}],"contact":[{"name":"Elodie;SPEYER","firstname":"Elodie","lastname":"SPEYER","email":"elodie.speyer@inserm.fr"}],"deposit_req":"oui","cit_req":"oui"},"notes":""}},"additional":{"IsImport":false,"versionLang":"fr","originLang":"fr","lastUpdatedAuto":"03-07-2026","lastUpdatedManual":"03-07-2026","autoTranslation":false,"status":"Envoy\u00e9e pour publication","respValidation":"","isHealthTheme":false,"isContributorPI":false,"addTeamMember":false,"primaryInvestigator":{"isPIContact":false,"piMail":"gianluca.severi@inserm.fr","piAffiliation":{"piLabo":"Centre de recherche en \u00c9pid\u00e9miologie et Sant\u00e9 des Populations (CESP), \u00e9quipe Exposome et H\u00e9r\u00e9dit\u00e9"}},"relatedDocument":[{"type":"","title":"Site web d\u00e9di\u00e9e \u00e0 la cohorte","link":"www.e3n-generations.fr"}],"contactPointLabo":"Centre de recherche en \u00c9pid\u00e9miologie et Sant\u00e9 des Populations (CESP), \u00e9quipe Exposome et H\u00e9r\u00e9dit\u00e9","obtainedAuthorization":{"otherAuthorizingAgency":["",""]},"regulatoryRequirements":{"conformityDeclaration":"MR-001"},"fundingAgent":{"fundingAgentType":["Public (France)","Public (France)","Public (France)","Priv\u00e9 \u00e0 but non lucratif","Priv\u00e9 \u00e0 but non lucratif","Priv\u00e9 \u00e0 but non lucratif","Public (France)"],"otherFundingAgentType":["","","","","","",""]},"sponsor":{"sponsorType":["Public (France)","Priv\u00e9 \u00e0 but non lucratif","Public (France)"],"otherSponsorType":["","",""]},"governance":{"committee":true},"collaborations":{"networkConsortium":true},"theme":{"complementaryInformation":"","RareDiseases":false},"interventionalStudy":{"researchPurpose":[],"trialPhase":[],"interventionalStudyModel":"","isClinicalTrial":"","otherResearchPurpose":""},"isInclusionGroups":true,"allocation":{"allocationMode":"","allocationUnit":""},"masking":{"maskingType":"","blindedMaskingDetails":[]},"arms":[],"intervention":[{"name":"exposome","type":"Sant\u00e9 publique","typeOther":""},{"name":"mode de vie","type":"Comportementale","typeOther":""},{"name":"alimentation","type":"Comportementale","typeOther":""},{"name":"Traitements","type":"M\u00e9dicament","typeOther":""},{"name":"G\u00e8nes","type":"G\u00e9n\u00e9tique","typeOther":""},{"name":"Ant\u00e9c\u00e9dents familiaux","type":"G\u00e9n\u00e9tique","typeOther":""}],"cohortLongitudinal":{"recrutementTiming":[]},"otherResearchType":{"otherResearchTypeDetails":""},"inclusionGroups":[{"name":"Femmes de la premi\u00e8re g\u00e9n\u00e9ration (Femmes G1)","description":"Les femmes de la cohorte E3N qui sont le socle de la cohorte familiale"},{"name":"Hommes de la premi\u00e8re g\u00e9n\u00e9ration (Hommes G1)","description":"Les hommes avec qui les femmes G1 ont eu des enfants"},{"name":"G\u00e9n\u00e9ration 2 (G2)","description":"Les enfants (fils et filles) des femmes G1"},{"name":"G\u00e9n\u00e9ration 3 (G3)","description":"Les petits-enfants (petits-fils et petites-filles) des femmes G1"}],"nrInclusionGroups":false,"collectionProcess":{"collectionModeDetails":"Pour G1 : auto-questionnaires papier ; Pour G2 et G3 : auto-questionnaires en ligne, traqueurs d'activit\u00e9 physique ; Pour tous : contacts avec m\u00e9decins","collectionModeOther":""},"dataCollection":{"inclusionStrategy":[],"samplingModeOther":"","recruitmentSourceOther":"Pour constituer cette cohorte familiale, recueil des coordonn\u00e9es des membres de la famille des femmes de la cohorte E3N aupr\u00e8s de ces femmes elles-m\u00eames puis des membres  E3N-G\u00e9n\u00e9rations, une fois inclus dans la cohorte, pour poursuivre l'inclusion des g\u00e9n\u00e9rations 2 et 3.","otherDocumentation":""},"activeFollowUp":{"isActiveFollowUp":true,"followUpModeOther":""},"dataCollectionIntegration":{"isDataIntegration":true},"geographicalCoverage":{"geoDetail":"France"},"dataTypes":{"clinicalDataDetails":"Compte-rendus d'anatomopathologie en cas de cancer d\u00e9clar\u00e9 et compte-rendu m\u00e9dicaux pour documenter les pathologies auto-d\u00e9clar\u00e9es","biologicalDataDetails":"Pour les Femmes G1 : sang frais, salive, sang sur buvard ; Pour les hommes G1 : salive, sang sur buvard ; Pour les G2 : sang sur buvard ; Pour les G2 et les G3 : collectes de salive, sang sur buvard, selles, cheveux et ongles pr\u00e9vues. 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