The French E3N Prospective Cohort Study FRESH-PEF3162-en CAMILLE LAPLANCHE The French E3N Prospective Cohort Study E3N Study FRESH-PEF3162-en 3162 FRESH-PEF3162 Gianluca SEVERI INSTITUT GUSTAVE ROUSSY (IGR) INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) UNIVERSITE PARIS-SACLAY Epidemiology France Portal (PEF) MINISTERE DE L’ENSEIGNEMENT SUPERIEUR, DE LA RECHERCHE ET DE L’ESPACE INSTITUT GUSTAVE ROUSSY (IGR) MUTUELLE GENERALE DE L EDUCATION NATIONALE (MGEN) INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) LIGUE NATIONALE CONTRE LE CANCER (LNCC) AGENCE NATIONALE DE LA RECHERCHE (ANR) null Elodie;SPEYER CNIL CPP exposome lifestyle nutrition environment pharmacoepidemiology genetics biomarkers Malignant neoplasms of breast Malignant neoplasms of colon Melanoma of skin Endometriosis Malignant neoplasms of ovary Malignant neoplasms of corpus uteri Type 2 diabetes mellitus Asthma Parkinson disease Diseases of the circulatory system Obesity COVID-19 Malignant neoplasm of pancreas Hodgkin and non-Hodgkin lymphomas Psoriasis Socio-demographic and economic determinants Socio-demographic and economic determinants: Employment Socio-demographic and economic determinants: Education level Socio-demographic and economic determinants: Age Environmental determinants Environmental determinants: Air quality Environmental determinants: Climate Environmental determinants: Other Healthcare system determinants Healthcare system determinants: Use of care Behavioral determinants Behavioral determinants: Eating habits Behavioral determinants: Physical activity Biological determinants Biological determinants: Genetic predisposition Biological determinants: Aging Biological determinants: Sex Detecting risk factors of cancer and chronic pathologies in women The E3N cohort forms the historical foundation of the French family cohort E3N-Générations. E3N is a prospective cohort study that follows 98,995 French women born between 1925 and 1950. She is interested in the impact of lifestyle, diet, the environment, and medical treatments on women's health. She focuses particularly on major chronic conditions such as cancer, diabetes, and cardiovascular disease. Since 1990, women in the E3N study have been completing and returning paper questionnaires approximately every three years. They are asked about their lifestyle (diet, physical activity, sedentary behavior, smoking, alcohol consumption, medication use, hormone therapy, etc.), their environment, and changes in their physical and mental health. Medical records are supplemented with reimbursement data from MGEN. Self-reported medical conditions are validated and detailed through collaboration with primary care physicians, pathology laboratories, and hospitals. The information from their questionnaires is supplemented by biological data: 25,000 E3N women provided a blood sample, and 47,000 provided a saliva sample. Thanks to the loyalty and consistency of the E3N women, participation in the study remains very high, even 35 years after enrollment. The study data—which are regularly updated, detailed, accurate, and validated—enable the research team to conduct work of excellent scientific quality. The E3N cohort forms the historical foundation of the E3N-Générations family cohort, which builds on it by inviting the children, the fathers of those children, and the grandchildren of the E3N women to participate in turn. France Individus General population Female Middle Aged (45 to 64 years) Aged (65 to 79 years) Aged, 80 and over (80 years and more) Women born between 1925 and 1950 and affiliated with MGEN (Mutuelle Générale de l'Education nationale) Clinical data Biological data Socio-demographic data Environmental / exposure data Behavioral data Geospatial data Economic data Genetic / genomic data Participant-reported health data ICD 9 and ICD 10 The Institutional Committee brings together the cohort’s founding partners: Paris-Saclay University, Inserm, Gustave Roussy, the National League Against Cancer, and MGEN. Its main responsibilities are: to validate strategic directions; to monitor the cohort’s progress and its budgetary status; to approve budget management, financial statements, and annual activity reports; to establish the procedures for evaluating the cohort and decide on its potential termination or extension; and to adopt a Charter governing access to the cohort’s data and samples. The Scientific Advisory Board, composed of international experts, ensures the relevance and scientific quality of research conducted using the cohort’s data and samples; it fosters collaborations by identifying expertise and know-how, and it provides input on the Data Access Charter. Health event/morbidity Health event/mortality Health care consumption and services Quality of life/health perception Prospective longitudinal About every 3 years Other Medical-administrative database (patients health insurance/mutual insurance) >= 20000 individuals Interview with the participant (including clinical) Self-administered questionnaire MGEN's Reimbursement Basis for Medical Care Data enrichment through cross-referencing Medico-administrative database CepiDC Passive participant monitoring Medico-administrative database Observational Study Observational Study Cohort study Monitoring by contact with the participant (mail, e-mail, telephone etc.) 98 995 Ongoing study on Gustave Roussy's secure servers Restricted access Data Access Policy https://demande-acces-donnees.portail-fresh.fr/cohortes/2/cohortesDetails Elodie;SPEYER yes yes Data access methods for outside teams: authorization request to the scientific committee of the E3N study Access on specific project only