20,000 Volunteers for Medical Research FRESH-PEF3476-en Marcel Goldberg 20,000 Volunteers for Medical Research GAZEL FRESH-PEF3476-en 3476 FRESH-PEF3476 Marie ZINS Marcel GOLDBERG INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) Epidemiology France Portal (PEF) Camieg CCAS CMCAS null Marie;ZINS Marcel;GOLDBERG CNIL adults occupational health social determinants aging General-purpose cohort COVID-19 Neoplasm, malignant Diseases of the musculoskeletal system or connective tissue Depressive disorders Acute myocardial infarction Stroke not known if ischaemic or haemorrhagic Socio-demographic and economic determinants Socio-demographic and economic determinants: Employment Socio-demographic and economic determinants: Income Socio-demographic and economic determinants: Housing Socio-demographic and economic determinants: Education level Socio-demographic and economic determinants: Family situation Socio-demographic and economic determinants: Gender Socio-demographic and economic determinants: Age Environmental determinants Environmental determinants: Air quality Environmental determinants: Other Healthcare system determinants Healthcare system determinants: Use of care Behavioral determinants Behavioral determinants: Addiction Behavioral determinants: Eating habits Behavioral determinants: Physical activity Behavioral determinants: Risk behavior Biological determinants Biological determinants: Genetic predisposition Occupational exposures GAZEL was set up in 1989 among workers of Électricité de France-Gaz de France (EDF-GDF). It was designed as an “open epidemiologic laboratory” characterized by a broad coverage of health problems and determinants and accessible to the community of researchers. At study inception in 1989, the GAZEL Cohort Study included 20,625 volunteers (15,011 men and 5,614 women) then aged from 35 to 50 years. The data routinely collected cover diverse dimensions and come from different sources: annual self-administered questionnaire (morbidity, lifestyles, life events, etc.); personnel department of EDF-GDF for social, demographic, and occupational characteristics; EDF-GDF special social insurance fund (for sickness absences and cancer and ischemic heart disease registries), occupational medicine (occupational exposure and working conditions), Social Action Fund (healthcare utilization), Health Screening Centres for standardized health examination and the National Death Register (causes of death); a biobank including more than 8,000 blood samples was also set up. Today, more than 40 ancillary projects on diversified themes have been set up in the GAZEL Cohort Study by some 30 French and foreign teams from Denmark, Germany, Belgium, Canada, Great Britain, Sweden, Finland, and USA. Health problems as diverse as migraine, postmenopausal osteoporosis, ischemic heart disease, depression, musculoskeletal diseases, or traffic accidents have been the object of research projects in this cohort. They take into account risk factors that are behavioural, social, psychological, occupational, and medical. A substantial proportion of the research work has focused on the problem of social inequalities in health and their occupational, personal, and social determinants using a life course perspective. The GAZEL cohort was established in 1989 among employees of Électricité de France-Gaz de France (EDF-GDF). In 1989, GAZEL recruited 20,625 volunteers working at EDF-GDF who were then between the ages of 35 and 50 (15,011 men and 5,614 women). The cohort is diverse in terms of social, economic, and occupational status, health, and health-related behaviors. The collected data cover various dimensions and come from different sources: an annual self-administered questionnaire (morbidity, lifestyle, life events, etc.); EDF-GDF human resources department for social, demographic, and occupational characteristics; special social security scheme, occupational medicine, SNDS (outpatient and inpatient care, causes of death), and Social Security Health Examination Centers. A biobank is associated with the cohort. France Individus General population Female Male Adult (25 to 44 years) Middle Aged (45 to 64 years) Aged (65 to 79 years) Aged, 80 and over (80 years and more) EDF-GDF workers aged 35-50 at inception. Biological data Socio-demographic data Environmental / exposure data Behavioral data Geospatial data Economic data Genetic / genomic data Participant-reported health data ICD-10 CCAM ATC Shared with CS de Constances (https://www.constances.fr/espace-scientifique/csi/) Internal controls Health event/morbidity Health event/mortality Health care consumption and services Quality of life/health perception Well being Quality of Life Prospective longitudinal Annual Complete enumeration (including consecutive recruitment) Other Administrative database (employees pupils students etc.) >= 20000 individuals Self-administered questionnaire Other Medical and Administrative Office SNDS Data enrichment through cross-referencing Administrative database Medico-administrative database Administrative files EDF-GDF Files Data enrichment through cross-referencing Administrative database Medico-administrative database Observational Study Observational Study Cohort study Monitoring by contact with the participant (mail, e-mail, telephone etc.) 20,625 Ongoing study CASD Restricted access https://www.gazel.inserm.fr/index.php/fr/projets/proposer-un-projet-de-recherche Access via aCASD only Marcel;GOLDBERG Requirement to publish results Scientific Reports, MR04 Permanent call for research projects Data catalogue available on dedicated website Free access