{"doc_desc":{"title":"Cohorte \"Vingt mille volontaires pour la recherche m\u00e9dicale\"","idno":"FRESH-PEF3476-fr","producers":[{"name":"Marcel Goldberg","affiliation":"INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)"}]},"study_desc":{"title_statement":{"idno":"FRESH-PEF3476-fr","IDno":{"metadata_no":[{"agency":"PEF","code":"3476"},{"agency":"FReSH","code":"FRESH-PEF3476"}],"metadata_yes":[{"code":"FReSH","agency":"FReSH"}]},"title":"Cohorte \"Vingt mille volontaires pour la recherche m\u00e9dicale\"","alternate_title":"GAZEL"},"study_authorization":{"agency":[{"name":"CNIL"}]},"authoring_entity":[{"name":"Marie;ZINS","firstname":"Marie","lastname":"ZINS","type":"investigator","extlink":[{"title":"ORCID","uri":"0000-0002-4540-4282","role":"pi id"},{"title":"IdRef","uri":" 074613324","role":"pi id"},{"title":"ROR","uri":"https:\/\/ror.org\/02vjkv261","role":"organisation id"},{"title":"SIREN","uri":"180036048","role":"organisation 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MEDICALE (INSERM)","contactPointLabo":"Paris Cit\u00e9\nINSERM \/ UMS 011 : Cohortes \u00e9pid\u00e9miologiques en population","extlink":[{"title":"ROR","uri":"https:\/\/ror.org\/02vjkv261","role":"organisation id"},{"title":"SIREN","uri":"180036048","role":"organisation id"},{"title":"RNSR","uri":"201322808P","role":"labo id"}]},{"name":"Marcel;GOLDBERG","lastname":"GOLDBERG","firstname":"Marcel","type":"contact","email":"marcel.goldberg@inserm.fr","affiliationName":"Univesit\u00e9 Paris Cit\u00e9","contactPointLabo":"Inserm UMS 11","extlink":[{"title":"ROR","uri":"https:\/\/ror.org\/03xjwb503","role":"organisation id"},{"title":"SIREN","uri":"130026024","role":"organisation id"},{"title":"RNSR","uri":"201322808P","role":"labo id"}]}]},"study_info":{"keywords":[{"keyword":"Cohorte g\u00e9n\u00e9raliste"},{"keyword":"d\u00e9terminants sociaux"},{"keyword":"adultes"},{"keyword":"vieillissement"},{"keyword":"risques professionnels"}],"topics":[{"topic":"COVID-19","vocab":"cim-11","extLink":[{"title":"CIM-11","uri":"http:\/\/id.who.int\/icd\/entity\/1730556128"}]},{"topic":"Tumeur maligne","vocab":"cim-11","extLink":[{"title":"CIM-11","uri":"http:\/\/id.who.int\/icd\/entity\/50574435"}]},{"topic":"Maladies du syst\u00e8me musculosquelettique ou du tissu conjonctif","vocab":"cim-11","extLink":[{"title":"CIM-11","uri":"http:\/\/id.who.int\/icd\/entity\/1473673350"}]},{"topic":"Troubles d\u00e9pressifs","vocab":"cim-11","extLink":[{"title":"CIM-11","uri":"http:\/\/id.who.int\/icd\/entity\/1563440232"}]},{"topic":"Infarctus aigu du myocarde","vocab":"cim-11","extLink":[{"title":"CIM-11","uri":"http:\/\/id.who.int\/icd\/entity\/1334938734"}]},{"topic":"Accident vasculaire c\u00e9r\u00e9bral, non pr\u00e9cis\u00e9 comme \u00e9tant h\u00e9morragique ou isch\u00e9mique","vocab":"cim-11","extLink":[{"title":"CIM-11","uri":"http:\/\/id.who.int\/icd\/entity\/1442995018"}]},{"topic":"D\u00e9terminants socio-d\u00e9mographiques et \u00e9conomiques","vocab":"health determinant"},{"topic":"D\u00e9terminants socio-d\u00e9mographiques et \u00e9conomiques : Emploi","vocab":"health determinant"},{"topic":"D\u00e9terminants socio-d\u00e9mographiques et \u00e9conomiques : Revenu","vocab":"health determinant"},{"topic":"D\u00e9terminants socio-d\u00e9mographiques et \u00e9conomiques : Logement","vocab":"health determinant"},{"topic":"D\u00e9terminants socio-d\u00e9mographiques et \u00e9conomiques : Niveau d'\u00e9tudes","vocab":"health determinant"},{"topic":"D\u00e9terminants socio-d\u00e9mographiques et \u00e9conomiques : Situation familiale","vocab":"health determinant"},{"topic":"D\u00e9terminants socio-d\u00e9mographiques et \u00e9conomiques : Genre","vocab":"health determinant"},{"topic":"D\u00e9terminants socio-d\u00e9mographiques et \u00e9conomiques : \u00c2ge","vocab":"health determinant"},{"topic":"D\u00e9terminants environnementaux","vocab":"health determinant"},{"topic":"D\u00e9terminants environnementaux : Qualit\u00e9 de l'air","vocab":"health determinant"},{"topic":"D\u00e9terminants environnementaux : Autre","vocab":"health determinant"},{"topic":"D\u00e9terminants li\u00e9s au syst\u00e8me de sant\u00e9","vocab":"health determinant"},{"topic":"D\u00e9terminants li\u00e9s au syst\u00e8me de sant\u00e9 : Consommation des soins","vocab":"health determinant"},{"topic":"D\u00e9terminants comportementaux","vocab":"health determinant"},{"topic":"D\u00e9terminants comportementaux : Addiction","vocab":"health determinant"},{"topic":"D\u00e9terminants comportementaux : Alimentation","vocab":"health determinant"},{"topic":"D\u00e9terminants comportementaux : Activit\u00e9 physique","vocab":"health determinant"},{"topic":"D\u00e9terminants comportementaux : Comportements \u00e0 risque","vocab":"health determinant"},{"topic":"D\u00e9terminants biologiques","vocab":"health determinant"},{"topic":"D\u00e9terminants biologiques : Pr\u00e9disposition g\u00e9n\u00e9tique","vocab":"health determinant"},{"topic":"Expositions profesionnelles","vocab":"other environmental determinant"}],"purpose":"Mise en place en 1989, cette cohorte est compos\u00e9e de 20 625 agents d\u2019EDF-GDF \u00e2g\u00e9s de 35 \u00e0 50 ans \u00e0 l\u2019origine. Elle a \u00e9t\u00e9 con\u00e7ue pour \u00eatre ouverte \u00e0 la communaut\u00e9 scientifique. Les donn\u00e9es font l\u2019objet d\u2019un recueil syst\u00e9matique aupr\u00e8s de diff\u00e9rentes sources. Une banque de mat\u00e9riel biologique a \u00e9t\u00e9 constitu\u00e9e. Apr\u00e8s plus de 22 ans de suivi, plus d\u2019une quarantaine de projets de recherche, concernant des sujets aussi divers que la migraine, l\u2019ost\u00e9oporose, les maladies cardiovasculaires, la d\u00e9pression, les troubles musculo-squelettiques, ou les accidents de la route ont \u00e9t\u00e9 mis en place par une trentaine d\u2019\u00e9quipes fran\u00e7aises et \u00e9trang\u00e8res (Allemagne, Belgique, Canada, Grande-Bretagne, Su\u00e8de, Finlande, USA). Dans les prochaines ann\u00e9es, les orientations scientifiques concerneront plus particuli\u00e8rement l\u2019\u00e9tude du vieillissement (effets \u00e0 long terme des expositions professionnelles, vieillissement cognitif et fonctionnel pr\u00e9matur\u00e9, troubles musculosquelettiques et qualit\u00e9 de vie, in\u00e9galit\u00e9s sociales de sant\u00e9 chez les personnes \u00e2g\u00e9es).","abstract":"La cohorte GAZEL a \u00e9t\u00e9 mise en place en 1989 aupr\u00e8s des salari\u00e9s d'\u00c9lectricit\u00e9 de France-Gaz de France (EDF-GDF). En 1989, GAZEL a recrut\u00e9 20 625 volontaires travaillant \u00e0 EDF-GDF alors \u00e2g\u00e9s de 35 \u00e0 50 ans (15 011 hommes et 5614 femmes). La cohorte est diversifi\u00e9e en termes de statut social, \u00e9conomique et professionnel, de sant\u00e9 et de comportement li\u00e9 \u00e0 la sant\u00e9. Les donn\u00e9es collect\u00e9es couvrent diverses dimensions et proviennent de diff\u00e9rentes sources : questionnaire auto-administr\u00e9 annuel (morbidit\u00e9, modes de vie, \u00e9v\u00e9nements de la vie, etc.); service du personnel d'EDF-GDF pour les caract\u00e9ristiques sociales, d\u00e9mographiques et professionnelles; r\u00e9gime sp\u00e9cial de s\u00e9curit\u00e9 sociale, m\u00e9decine du travail, SNDS (soins de ville et hospitaliers, causes de d\u00e9c\u00e8s), Centres d\u2019examens de sant\u00e9 de la s\u00e9curit\u00e9 sociale. Une biobanque est associ\u00e9e \u00e0 la cohorte.","coll_dates":[{"start":"1989-01-01","end":"2025-12-31"}],"nation":[{"name":"France","abbreviation":"fr","extLink":{"vocab":"ISO","vocabURI":"fr"}}],"geog_coverage":"","analysis_unit":"Individus","universe":"{\n    \"level_sex_clusion_I\": [\n        {\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"D005260\"\n            },\n            \"value\": \"F\u00e9minin\"\n        },\n        {\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"D008297\"\n            },\n            \"value\": \"Masculin\"\n        }\n    ],\n    \"level_age_clusion_I\": [\n        {\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"D000328\"\n            },\n            \"value\": \"Adulte (25 \u00e0 44 ans)\"\n        },\n        {\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"D008875\"\n            },\n            \"value\": \"Adulte (45 \u00e0 64 ans)\"\n        },\n        {\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"D000368\"\n            },\n            \"value\": \"Personne \u00e2g\u00e9e (65 \u00e0 79 ans)\"\n        },\n        {\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"D000369\"\n            },\n            \"value\": \"Grand \u00e2ge (80 ans et plus)\"\n        }\n    ],\n    \"level_type_clusion_I\": \"Population g\u00e9n\u00e9rale\",\n    \"level_type_clusion_other\": \"\",\n    \"clusion_I\": \"Agents EDF-GDF \u00e2g\u00e9s de 35 \u00e0 50 ans en 1989.\",\n    \"clusion_E\": \"\"\n}","data_kind":"['Donn\u00e9es biologiques','Donn\u00e9es socio-d\u00e9mographiques','Donn\u00e9es environnementales \/ d'exposition','Donn\u00e9es comportementales','Donn\u00e9es g\u00e9ospatiales','Donn\u00e9es \u00e9conomiques','Donn\u00e9es g\u00e9n\u00e9tiques \/ g\u00e9nomiques','Donn\u00e9es de sant\u00e9 rapport\u00e9es par les participants de l'\u00e9tude']","quality_statement":{"standards":[{"name":"['CIM 10, CCAM, ATC']","committee":"Commun avec CS de Constances (https:\/\/www.constances.fr\/espace-scientifique\/csi\/)","governance":""}],"other_quality_statement":"['Contr\u00f4les internes']"}},"study_development":{"development_activity":[{"activity_type":"primary evaluation","activity_description":"Ev\u00e9nements de sant\u00e9\/morbidit\u00e9\r\nEv\u00e9nements de sant\u00e9\/mortalit\u00e9\r\nConsommation de soins\/services de sant\u00e9\r\nQualit\u00e9 de vie\/sant\u00e9 per\u00e7ue"},{"activity_type":"secondary evaluation","activity_description":"Bien-\u00eatre  Qualit\u00e9 de vie"}]},"method":{"data_collection":{"time_method":"Longitudinale prospective","frequency":"Annuelle","sampling_procedure":"['{\"concept\":{\"vocab\":\"CESSDA\",\"vocabURI\":\"TotalUniverseCompleteEnumeration\"},\"value\":\"D\u00e9nombrement complet (dont recrutement cons\u00e9cutif)\"}','{\"concept\":{\"vocab\":\"CESSDA\",\"vocabURI\":\"Other\"},\"value\":\"Autre\"}']","sample_frame":{"frame_unit":{"unit_type":"['Base administrative (d'employ\u00e9s, d'\u00e9l\u00e8ves, d'\u00e9tudiants, etc\u2026)']"}},"coll_mode":["{\"concept\":{\"vocab\":\"CESSDA\",\"vocabURI\":\"SelfAdministeredQuestionnaire\"},\"value\":\"Questionnaire auto-administr\u00e9\"}","{\"concept\":{\"vocab\":\"CESSDA\",\"vocabURI\":\"Other\"},\"value\":\"Autre\"}"],"research_instrument":"Acc\u00e8s libre","sources":[{"sourceCitation":{"titlStmt":{"titl":"Base m\u00e9dico-administrative"},"holdings":"SNDS","notes":{"subject":"source purpose","value":"Enrichissement des donn\u00e9es par croisement (autre que le suivi passif)"}},"srcOrig":["Base administrative","Base m\u00e9dico-administrative"]},{"sourceCitation":{"titlStmt":{"titl":"Fichiers admiistratifs"},"holdings":"Fichiers EDF-GDF","notes":{"subject":"source purpose","value":"Enrichissement des donn\u00e9es par croisement (autre que le suivi passif)"}},"srcOrig":["Base administrative","Base m\u00e9dico-administrative"]}],"target_sample_size":">= 20000 individus","response_rate":"20,625"},"method_notes":"Etude observationnelle","study_class":"\u00c9tude en cours","notes":[{"subject":"research type","values":["Etude observationnelle"]},{"subject":"observational study method","values":["Cohorte"]},{"subject":"follow-up","values":["Suivi par contact avec le participant (t\u00e9l\u00e9phone, e-mail, courrier...)"]}]},"data_access":{"dataset_availability":{"access_place":"CASD","complete":"","status":"{\"extLink\":{\"title\":\"COAR\",\"uri\":\"http:\/\/purl.org\/coar\/access_right\/c_16ec\"},\"value\":\"Acc\u00e8s r\u00e9serv\u00e9\"}"},"dataset_use":{"restrictions":"Acc\u00e8s uniquement vi aCASD","conditions":"Dossiers scientifique, MR04","conf_dec":[{"txt":""}],"spec_perm":[{"txt":"https:\/\/www.gazel.inserm.fr\/index.php\/fr\/projets\/proposer-un-projet-de-recherche","required":"Oui"}],"contact":[{"name":"Marcel;GOLDBERG","firstname":"Marcel","lastname":"GOLDBERG","email":"marcel.goldberg@inserm.fr"}],"deposit_req":"Obligation de publier les r\u00e9sultats","cit_req":""},"notes":"Appel \u00e0 projet de recherche permanent Catalogue des donn\u00e9es de la cohorte disponible sur le site web d\u00e9di\u00e9 Charte d'acc\u00e8s"}},"additional":{"IsImport":false,"versionLang":"fr","originLang":"fr","lastUpdatedAuto":"13-05-2026","lastUpdatedManual":"13-05-2026","autoTranslation":false,"status":"Envoy\u00e9e pour publication","respValidation":"","isHealthTheme":false,"isContributorPI":false,"addTeamMember":"","primaryInvestigator":{"isPIContact":true,"piMail":"marcel.goldberg@inserm.fr","piAffiliation":{"piLabo":"Inserm UMS 11"}},"relatedDocument":[{"type":"Publication 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(France)"],"otherSponsorType":[""]},"governance":{"committee":true},"collaborations":{"networkConsortium":true},"theme":{"complementaryInformation":"","RareDiseases":false},"interventionalStudy":{"researchPurpose":[],"trialPhase":[],"interventionalStudyModel":"","isClinicalTrial":"","otherResearchPurpose":""},"isInclusionGroups":false,"allocation":{"allocationMode":"","allocationUnit":""},"masking":{"maskingType":"","blindedMaskingDetails":[]},"arms":[],"intervention":[{"name":"Multi expositions","type":"Combinaison","typeOther":""}],"cohortLongitudinal":{"recrutementTiming":[]},"otherResearchType":{"otherResearchTypeDetails":""},"inclusionGroups":[],"nrInclusionGroups":false,"collectionProcess":{"collectionModeDetails":"Autoquestionnaire postal annuel, Suivi dans des bases de donn\u00e9es : les principaux \u00e9v\u00e9nements socioprofessionnels proviennent des services du personnel. Les donn\u00e9es de sant\u00e9 concernent le statut vital et les causes de d\u00e9c\u00e8s du C\u00e9piDc-Inserm ; les principaux \u00e9v\u00e9nements de sant\u00e9 sont extraits du Syst\u00e8me national d\u2019information inter r\u00e9gimes de l\u2019assurance maladie (SNDS) : donn\u00e9es de remboursement, Affections de longue dur\u00e9e (ALD), et pour chacun des s\u00e9jours hospitaliers : diagnostic principal et diagnostics associ\u00e9s, actes diagnostiques et th\u00e9rapeutiques.","collectionModeOther":"Donn\u00e9es administratives, SNDS"},"dataCollection":{"inclusionStrategy":[],"samplingModeOther":"Invitation totalit\u00e9 population \u00e9ligible","recruitmentSourceOther":"","otherDocumentation":""},"activeFollowUp":{"isActiveFollowUp":true,"followUpModeOther":""},"dataCollectionIntegration":{"isDataIntegration":true},"geographicalCoverage":{"geoDetail":"France enti\u00e8re"},"dataTypes":{"clinicalDataDetails":"","biologicalDataDetails":"R\u00e9gulation glyc\u00e9mique, bilan lipidique, bilan h\u00e9patique, cr\u00e9atin\u00e9mie, num\u00e9ration formule sanguine, examen urinaire.","isDataInBiobank":true,"biobankContent":["Plasma","S\u00e9rum"],"biobankContentOther":"","dataTypeOther":"","paraclinicalDataOther":"","otherLiquidsDetails":""},"variableDictionnary":{"variableDictionnaryAvailable":true,"variableDictionnaryLink":"https:\/\/www.gazel.inserm.fr\/documentation\/catalogue-des-donnees"},"dataQuality":{"otherDocumentation":""},"mockSample":{"mockSampleAvailable":false,"mockSampleLocation":""},"thirdPartySource":{"otherSourceType":["",""]},"fileDscr":{"fileTxt":{"fileCitation":{"titlStmt":{"IDno":[]}}}}},"schematype":"survey"}