Case-Control Study on Sweetness Preference in Alcohol Dependence FRESH-PEF8912-en Philip GORWOOD Case-Control Study on Sweetness Preference in Alcohol Dependence AGEPSA FRESH-PEF8912-en 8912 FRESH-PEF8912 Philip GORWOOD Alexandra DEREUX INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) CENTRE HOSPITALIER SAINTE ANNE PARIS Epidemiology France Portal (PEF) CENTRE HOSPITALIER SAINTE ANNE PARIS INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) null Philip;GORWOOD Alexandra;DEREUX preference sweet sugar endophenotype case-control matching precocity impulsiveness hedonic response alcohol dependence severity family history sensation vulnerability Endocrinology Psychiatry Addiction medicine Behavioral determinants: Addiction Socio-demographic and economic determinants Biological determinants: Genetic predisposition Behavioral determinants Biological determinants The main objective is to investigate the endophenotypic nature of sweet-liking in alcohol-dependence and to verify that the preference for sweetness is more common in subjects that are first-degree relatives of alcohol-dependent subjects than in control subjects. Secondary objectives include: studying specific clinical (precocity, severity), family (family history), temperamental (sensation seeking, impulsiveness) and cognitive traits (measurement of visual hedonic response, IGT decision-making tasks) in alcohol-dependent subjects that prefer the sweetest solutions; investigating the mechanisms involved in this endophenotypic connection and testing the following hypotheses: - Either the preference for the sweetest solutions is secondary to alcohol dependence; - Either the preference for sweetness is a marker of vulnerability to alcohol-dependence (sweetness preference would be a marker of an alcoholic sub-type associated with a higher genetic vulnerability that is close to Cloninger's clinical type 2 classification). null France Ile-de-France Individuals Patients population Male Female Young Adult (19 to 24 years) Adult (25 to 44 years) Middle Aged (45 to 64 years) Individuals aged between 18 and 65 years old; - Alcohol-dependent* patients that have been weaned for at least a week (according to DSM-IV criteria); - Control subjects exposed to alcohol consumption but who do not fulfil dependence criteria*; - Individuals that are first-degree relatives of an alcohol-dependent person with no personal dependence criterion*. Individuals with an eating disorder, body mass index lower than 18 or greater than 30, or diabetes. Clinical data Others Other Through organizations (health services or institutions schools businesses etc.) < 500 individuals Converting or copying information into a structured record Interview with the participant (including clinical) Observational Study Observational Study Case-control study 500 (300 patients/cases, 100 controls and 100 relations/controls). Unknown Restricted access Contact the scientist in charge for further information. Access on specific project only