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      <titl>Intensification of insulin therapy used in type-2 diabetes patients treated by the association of oral diabetes medication and basal insulin</titl>
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    <titlStmt>
      <titl>
                Intensification of insulin therapy used in type-2 diabetes patients treated by the association of oral diabetes medication and basal insulin            </titl>
      <altTitl>
                    INTENSIVE                </altTitl>
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                FRESH-PEF88-en            </IDNo>
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                    88                </IDNo>
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                    FRESH-PEF88                </IDNo>
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                    Franck VIGNAL                                                                                                                            </AuthEnty>
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                                            SANOFI (FRANCE)                    
                                    </producer>
      <prodPlac>
                Epidemiology France Portal (PEF)            </prodPlac>
      <fundAg>
                                            AGENCE NATIONALE DE RECHERCHES SUR LE SIDA ET LES HEPATITES VIRALES (ANRS MIE)                    
                                    </fundAg>
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  <stdyInfo>
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    <subject>
      <keyword vocab="" vocabURI="">
                    intensification of insulin therapy</keyword>
      <topcClas vocab="health theme">
                        Endocrinology                                                        <ExtLink title="ESV" URI="http://data.europa.eu/8mn/euroscivoc/d1dd1bac-5313-4ab3-837f-4acd3ec521a7"/>
                                                            <ExtLink title="MeSH" URI="http://id.nlm.nih.gov/mesh/D004704"/>
                                                </topcClas>
      <topcClas vocab="cim-11">
                        Type 2 diabetes mellitus                                            </topcClas>
    </subject>
    <abstract contentType="purpose">Describe the evolution of HbA1c at 6 months under different therapeutic strategies for the intensification of insulin therapy used in type-2 diabetes patients treated by the association of oral diabetes medication and basal insulin requiring the adding of rapid insulin</abstract>
    <abstract contentType="abstract">null</abstract>
    <sumDscr>
      <collDate event="start" date="2008-01-01"/>
      <collDate event="end" date="2009-01-01"/>
      <nation abbr="fr">
                    France
                                            <concept vocab="ISO" vocabURI="fr"/>
                                    </nation>
      <geogUnit/>
      <anlyUnit>
                Individuals            </anlyUnit>
      <universe level="type" clusion="I">Patients population                    </universe>
      <universe level="sex" clusion="I">Male                                                            <concept vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D008297"/>
                                                    </universe>
      <universe level="sex" clusion="I">Female                                                            <concept vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D005260"/>
                                                    </universe>
      <universe level="age" clusion="I">Middle Aged (45 to 64 years)                                                            <concept vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D008875"/>
                                                    </universe>
      <universe level="age" clusion="I">Aged (65 to 79 years)                                                            <concept vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D000368"/>
                                                    </universe>
      <universe clusion="I">man or woman, over the age of 18 years, having type-2 diabetes meeting the criteria of the HAS: treated by the association of oral diabetes medication and basal insulin (semi slow or slow-acting) and requiring the adding of rapid insulin.                    </universe>
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      <description>Health event/morbidity</description>
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    <dataColl>
      <timeMeth>One-time cross-sectional study</timeMeth>
      <sampProc>Other                                                            <concept vocab="CESSDA" vocabURI="Other"/>
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      <targetSampleSize>
        <sampleSizeFormula>&lt; 500 individuals                        </sampleSizeFormula>
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      <collMode>Other                                                            <concept vocab="CESSDA" vocabURI="Other"/>
                                                    </collMode>
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    <notes>Observational Study</notes>
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                        Observational Study                    </notes>
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    <stdyClas>Completed study</stdyClas>
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                            To be defined                                                    </avlStatus>
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    <relMat>Access on specific project only</relMat>
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