Longitudinal Study on Aortic Regurgitation in Patients Treated with Benfluorex FRESH-PEF8761-en Mahmoud ZUREIK Longitudinal Study on Aortic Regurgitation in Patients Treated with Benfluorex REFLEX FRESH-PEF8761-en 8761 FRESH-PEF8761 Mahmoud ZUREIK INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) Epidemiology France Portal (PEF) MINISTERE DU TRAVAIL, DE LA SANTE, DES SOLIDARITES ET DES FAMILLES null Mahmoud;ZUREIK Benfluorex marketing authorisation MA research side effects post adverse events study Cardiology and vascular medicine Diseases of the circulatory system Healthcare system determinants: Use of care Healthcare system determinants Echocardiography-based study on the development of valvular disease (decrease, stable, increase) in patients treated with benfluorex. To compare the development of valvular diseases potentially linked to benfluorex and diseases not linked to benfluorex. - All patients and patients with valvular disease potentially linked to benfluorex; assessment of development with regards to: - Indication(s), duration of exposure to benfluorex and duration since stopping medication. - Age and sex; - diabetes and associated medical treatment. - Presence of cardiac and non-cardiac diseases; - current treatments and treatments that were undergone simultaneously with benfluorex. null France Individuals Patients population Male Female Young Adult (19 to 24 years) Adult (25 to 44 years) Middle Aged (45 to 64 years) Male and female; - Adult; - Patient treated with benfluorex from 2006-2009 with aortic/mitral grade regurgitation. Clinical data Paraclinical data (non-biological) : Imaging Health event/morbidity Other Through organizations (health services or institutions schools businesses etc.) [500-1000[ individuals Interview with the participant (including clinical) Observational Study Observational Study 1,000 Unknown Restricted access Contact the principal investigator Access on specific project only