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    <titlStmt>
      <titl>Karolinska-Rennes Cohort: Cardiac Dyssynchrony in Patients with Heart Failure and Preserved Ejection Fraction</titl>
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      <producer abbr="" affiliation="SOC FRANCAISE DE CARDIOLOGIE" role="">Geneviève MULAK</producer>
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    <titlStmt>
      <titl>
                Karolinska-Rennes Cohort: Cardiac Dyssynchrony in Patients with Heart Failure and Preserved Ejection Fraction            </titl>
      <altTitl>
                    KaRen                </altTitl>
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                FRESH-PEF8678-en            </IDNo>
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                    8678                </IDNo>
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                    FRESH-PEF8678                </IDNo>
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      <AuthEnty>
                    Jean-Claude DAUBERT                                                                                </AuthEnty>
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        <ExtLink title="ROR" URI="https://ror.org/05qec5a53" role="organisation id"/>
      </AuthEnty>
      <AuthEnty>
                    Erwan DONAL                                                                                </AuthEnty>
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        <ExtLink title="ROR" URI="https://ror.org/05qec5a53" role="organisation id"/>
      </AuthEnty>
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                                    </othId>
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      <producer role="sponsor">
                                            ASSOCIATION DE SOUTIEN A LA FILIALE D&amp;#039;IMAGERIE CARDIOVASCULAIRE DE LA SOCIETE FRANCAISE DE CARDIOLOGIE (ASFIC)                    
                                    </producer>
      <prodPlac>
                Epidemiology France Portal (PEF)            </prodPlac>
      <fundAg>
                                            ASSOCIATION DE SOUTIEN A LA FILIALE D&amp;#039;IMAGERIE CARDIOVASCULAIRE DE LA SOCIETE FRANCAISE DE CARDIOLOGIE (ASFIC)                    
                                    </fundAg>
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                    null</distrbtr>
      <contact affiliation="chu" email="jean-claude.daubert@chu-rennes.fr">
                    Jean-Claude;DAUBERT
                                            <ExtLink title="ROR" URI="https://ror.org/05qec5a53" role="organisation id"/>
                                    </contact>
      <contact affiliation="CENTRE HOSPITALIER UNIVERSITAIRE DE RENNES" email="erwan.donal@chu-rennes.fr">
                    Erwan;DONAL
                                            <ExtLink title="ROR" URI="https://ror.org/05qec5a53" role="organisation id"/>
                                    </contact>
      <depDate date="2026-06-17"/>
      <distDate date="2026-06-17"/>
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    <biblCit format="">
            </biblCit>
    <holdings URI="null"/>
    <notes> </notes>
  </citation>
  <stdyInfo>
    <studyBudget/>
    <subject>
      <keyword vocab="" vocabURI="">
                    atrial arrhythmia</keyword>
      <keyword vocab="" vocabURI="">
                    left ventricular ejection fraction</keyword>
      <keyword vocab="" vocabURI="">
                    HF</keyword>
      <keyword vocab="" vocabURI="">
                    heart failure</keyword>
      <keyword vocab="" vocabURI="">
                    LVEF</keyword>
      <keyword vocab="" vocabURI="">
                    prognosis</keyword>
      <keyword vocab="" vocabURI="">
                    prevalence</keyword>
      <topcClas vocab="health theme">
                        Cardiology and vascular medicine                                                        <ExtLink title="ESV" URI="http://data.europa.eu/8mn/euroscivoc/4455c187-2f2f-4cd1-a4dd-449f59d73b39"/>
                                                            <ExtLink title="ESV" URI="http://data.europa.eu/8mn/euroscivoc/c42fc6ec-b216-4a24-9e9d-f5e781c175a0"/>
                                                            <ExtLink title="MeSH" URI="http://id.nlm.nih.gov/mesh/D002309"/>
                                                </topcClas>
    </subject>
    <abstract contentType="purpose">The main aim is to test the prognostic value of electrical or mechanical cardiac dyssynchrony and to determine prevalence and characteristics in patients with heart failure and preserved left ventricular ejection fraction.</abstract>
    <abstract contentType="abstract">null</abstract>
    <sumDscr>
      <collDate event="start" date="2008-01-01"/>
      <collDate event="end" date="2012-01-01"/>
      <nation abbr="se">
                    Sweden
                                            <concept vocab="ISO" vocabURI="se"/>
                                    </nation>
      <nation abbr="fr">
                    France
                                            <concept vocab="ISO" vocabURI="fr"/>
                                    </nation>
      <geogUnit/>
      <anlyUnit>
                Individuals            </anlyUnit>
      <universe level="type" clusion="I">Patients population                    </universe>
      <universe level="sex" clusion="I">Male                                                            <concept vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D008297"/>
                                                    </universe>
      <universe level="sex" clusion="I">Female                                                            <concept vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D005260"/>
                                                    </universe>
      <universe level="age" clusion="I">Young Adult (19 to 24 years)                                                            <concept vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D055815"/>
                                                    </universe>
      <universe level="age" clusion="I">Adult (25 to 44 years)                                                            <concept vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D000328"/>
                                                    </universe>
      <universe level="age" clusion="I">Middle Aged (45 to 64 years)                                                            <concept vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D008875"/>
                                                    </universe>
      <universe level="age" clusion="I">Aged (65 to 79 years)                                                            <concept vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D000368"/>
                                                    </universe>
      <universe level="age" clusion="I">Aged, 80 and over (80 years and more)                                                            <concept vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D000369"/>
                                                    </universe>
      <universe clusion="I">Hospital visit OR hospitalisation for heart failure symptom; - Clinical signs of HF: - HF according to the Framingham criteria: 2 major criteria or 1 major + 2 minor criteria; - LVEF (Left Ventricular Fraction) greater or equal to 45% by echocardiography; - NT-proBNP greater than 300 pg/mL or BNP greater than 100.                      </universe>
      <universe clusion="E">Evidence of primary hypertrophic or restrictive cardiomyopathy, or systemic illness known to be associated with infiltrative heart disease; - Known right heart failure by pulmonary or pulmonary vascular disease not related to the left heart; - Pericardial constriction; - Restrictive or obstructive pulmonary disease, as evidenced by the requirement for home oxygen; - End-stage renal disease currently requiring dialysis; - Bi-ventricular pacemaker (CRT-P + ICD); - Acute coronary syndrome.                    </universe>
      <dataKind>Clinical data</dataKind>
      <dataKind>Participant-reported health data</dataKind>
      <dataKind>Biological data</dataKind>
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Health event/mortality
Quality of life/health perception</description>
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      <sampProc>Other                                                            <concept vocab="CESSDA" vocabURI="Other"/>
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        <sampleSizeFormula>&lt; 500 individuals                        </sampleSizeFormula>
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      <collMode>Converting or copying information into a structured record                                                            <concept vocab="CESSDA" vocabURI="Transcription"/>
                                                    </collMode>
      <collMode>Interview with the participant (including clinical)                                                            <concept vocab="CESSDA" vocabURI="Interview"/>
                                                    </collMode>
    </dataColl>
    <notes>Observational Study</notes>
    <notes subject="research type">
                        Observational Study                    </notes>
    <notes subject="observational study method">
                        Cohort study                    </notes>
    <anlyInfo>
      <respRate>362 (May 2012)</respRate>
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    <stdyClas>Unknown</stdyClas>
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      <avlStatus>
                            Restricted access                                                    </avlStatus>
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