Apathy in Schizophrenia: A Case-Control Clinical and Neuropsychological Study FRESH-PEF8593-en Richard LEVY Apathy in Schizophrenia: A Case-Control Clinical and Neuropsychological Study ASCHI FRESH-PEF8593-en 8593 FRESH-PEF8593 Richard LEVY INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) Epidemiology France Portal (PEF) ASSISTANCE PUBLIQUE HOPITAUX DE PARIS (AP-HP) INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) null Richard;LEVY apathy schizophrenia Neurology Psychiatry Schizophrenia Apathy Behavioral determinants The main objective is to confirm that schizophrenic patients are apathetic compared to health volunteers. Secondary objectives: - to investigate if apathy is related to a particular aspect of the disease (i.e., negative or positive symptomatology); - to investigate if apathy correlates with executive dysfunction; - to investigate if apathy is associated with a specific mechanism using an experimental task specially designed to characterise different mechanisms (i.e., "a-motivation", "cognitive inertia", and "uncoupling"); - to investigate if there is a volumetric abnormality affecting the executive system in apathetic schizophrenic patients; - to link these possible volumetric abnormalities to the prefrontal cortex-basal ganglia circuits according to a specific apathy subtype within the apathetic schizophrenic group. null France Ile-de-France Individuals Patients population Male Female Young Adult (19 to 24 years) Adult (25 to 44 years) Middle Aged (45 to 64 years) Healthy volunteers: -Male or female; -Aged 20 to 55; -With health insurance. Schizophrenia patients: -Male or female -Aged 20 to 55 -With health insurance -Daignosed as schizophrenic according to DSM-IV R criteria -Illness with a duration of over 5 years -Clinical stability during the past 2 months (defined as no treatment modification or hospitalisation 2 months prior to evaluation). Healthy volunteers: History of neurological disorder; -Previous head injury; -Alcohol or substance abuse; -On psychotropic medication; -Contraindication to MRI.Schizophrenia patients: Schizo-affective disorder; -History of neurological disorders (past or present); -Previous head injury; -Alcohol or substance abuse; -Contraindication to MRI. Clinical data Paraclinical data (non-biological) : Anthropometry Health event/morbidity Other Through organizations (health services or institutions schools businesses etc.) < 500 individuals Converting or copying information into a structured record Interview with the participant (including clinical) Observational Study Observational Study Case-control study 12 schizophrenic patients; 15 healthy volunteers. Unknown Restricted access Contact the principal investigator Access on specific project only