Monitoring of Exposure to Air Pollution during Pregnancy and Effect on Health FRESH-PEF8535-en Rémy SLAMA Monitoring of Exposure to Air Pollution during Pregnancy and Effect on Health SEPAGES, Sépages FRESH-PEF8535-en 8535 FRESH-PEF8535 Isabelle PIN Rémy SLAMA INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) Epidemiology France Portal (PEF) EUROPEAN COMMISSION RESEARCH AGENCE NATIONALE DE LA RECHERCHE (ANR) null Rémy;SLAMA atmospheric pollution respiratory health foetal growth epigenetics phenols bisphenol A Exposure foetus newborn pregnancy environment child phthalates BPA Endocrinology Gynaecology and obstetrics Neurology Paediatrics Pulmonary medicine Allergology Diseases of the respiratory system Environmental determinants: Climate Biological determinants: Genetic predisposition Environmental determinants: Other Behavioral determinants Behavioral determinants: Eating habits Environmental determinants Biological determinants The main objectives are: - to better characterise environmental exposure experienced during pregnancy and its impact on the health of a pregnant woman, foetus, newborn and child by paying particular attention to foetal growth and respiratory health - to study the biological mechanisms by which environmental factors might influence health, particularly epigenetic mechanisms. The targeted environmental factors are: - air pollutants (fine particles, nitrogen oxide, benzene and BTEX series) - endocrine disruptors, including phenols and phthalates - at term, exposome null France Auvergne Rhône-Alpes Individuals General population Male Female Infant, Newborn (birth to 28 days) Infant (28 days to 2 years) Child, Preschool (2 to 5 years) Young Adult (19 to 24 years) Adult (25 to 44 years) be aged over 18 years - be covered by a social security system (French or foreign) - be pregnant by 19 weeks and 6 days maximum - have a single pregnancy (and not twins) - reside in Isère, in an area not more than one hour from Grenoble - not be considering moving away from the inclusion area within the next two years Clinical data Participant-reported health data Biological data Environmental / exposure data Health event/morbidity Health care consumption and services Quality of life/health perception Others Other Through organizations (health services or institutions schools businesses etc.) [500-1000[ individuals Converting or copying information into a structured record Interview with the participant (including clinical) Observational Study Observational Study Cohort study 500 families (mother, father, child) (estimation) Unknown Restricted access Contact the principal investigator Access on specific project only