Cohort on Acute Liver Failure without Identified Cause FRESH-PEF8360-en Jean-Charles DUCLOS-VALLEE Cohort on Acute Liver Failure without Identified Cause HASI-PRO FRESH-PEF8360-en 8360 FRESH-PEF8360 Audrey COILLY Jean-Charles DUCLOS-VALLEE ASSISTANCE PUBLIQUE HOPITAUX DE PARIS (AP-HP) Epidemiology France Portal (PEF) ASSISTANCE PUBLIQUE HOPITAUX DE PARIS (AP-HP) null Audrey;COILLY Jean-Charles;DUCLOS-VALLEE Rare disease liver function indeterminate acute liver failure liver transplantation criteria for transplantation antibodies toxicology survival. cause etiology genetics Hepatology Acute or subacute hepatic failure Behavioral determinants Behavioral determinants: Eating habits Acute liver failure predictive factors known and validated and the default for patients admitted in a context of acute liver failure without identified cause and includes liver transplantation. The identification of new prognostic criteria which is essential for better care and improved survival of patients admitted for acute liver failure. Principal objective: - To determine early prognostic factors of mortality in patients admitted for acute liver failure without identified cause. Secondary objectives: - Describe the evolution of acute liver failure without identified cause in 3 months. - Search posterior rare acute liver failure causes: genetic study (polymorphism of the genes encoding cytokeratins 8 and 18), detection of novel antibodies by serum proteome analysis, toxicological study by mass spectrometry. null France Ile-de-France Individuals Patients population Male Female Young Adult (19 to 24 years) Adult (25 to 44 years) Middle Aged (45 to 64 years) Aged (65 to 79 years) Aged, 80 and over (80 years and more) Over the age of 18 - cytolysis and/or cholestasis WITH prothrombin time less than 50% or greater than 1.5 INR - signed informed consent by the patient or trusted person - without chronic underlying liver disease - cause of acute liver failure not identified at admission - non-participation in a therapeutic study may alter the patient's prognosis Clinical data Biological data Health event/morbidity Health event/mortality Health care consumption and services Other Through organizations (health services or institutions schools businesses etc.) < 500 individuals Physical/biological measurements (blood pressure, weight, biochemistry, imaging, etc.) Observational Study Observational Study Cohort study 100 Unknown Restricted access Contact the principal investigator Access on specific project only