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<docDscr>
  <citation>
    <titlStmt>
      <titl>International Study of Asthma and Allergies in Childhood in France</titl>
      <IDNo>FRESH-PEF8272-en</IDNo>
    </titlStmt>
    <prodStmt>
      <producer abbr="" affiliation="INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)" role="">Isabella ANNESI-MAESANO</producer>
    </prodStmt>
    <verStmt>
      <version></version>
    </verStmt>
  </citation>
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<stdyDscr>
  <citation>
    <titlStmt>
      <titl>
                International Study of Asthma and Allergies in Childhood in France            </titl>
      <altTitl>
                    ISAAC                </altTitl>
      <IDNo agency="FReSH-lang">
                FRESH-PEF8272-en            </IDNo>
      <IDNo agency="PEF">
                    8272                </IDNo>
      <IDNo agency="FReSH">
                    FRESH-PEF8272                </IDNo>
    </titlStmt>
    <rspStmt>
      <AuthEnty>
                    Isabella ANNESI-MAESANO                                                                                                                            </AuthEnty>
      <AuthEnty affiliation="INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)">
        <ExtLink title="ROR" URI="https://ror.org/02vjkv261" role="organisation id"/>
        <ExtLink title="SIREN" URI="180036048" role="organisation id"/>
      </AuthEnty>
      <othId affiliation="During ECHRS paediatrics. The project involves six hospital departments (Clermont-Ferrand, Marseille, Bordeaux, Reims, Strasbourg, Paris) and three specialist teams: &#x2022; epidemiology team: Dr I. Annesi-Maesano, G. Debotte, INSERM U 472), &#x2022; paediatric team: Prof. P. Scheinman, Dr. C. Karila, Dr. E. Paty (Necker-Enfants Malades Hospital, Paris) &#x2022; metrology team: M. Squinazi, Y. Le Moullec, M. Laurent (laboratoire d&#x2019;hygi&#xE8;ne de la ville de Paris [The City of Paris Hygiene Laboratory])." type="collaboration">
                                    </othId>
    </rspStmt>
    <prodStmt>
      <producer role="sponsor">
                                            INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)                    
                                    </producer>
      <prodPlac>
                Epidemiology France Portal (PEF)            </prodPlac>
      <fundAg>
                                            AGENCE DE L ENVIRONNEMENT ET DE LA MAITRISE DE L ENERGIE (ADEME)                    
                                    </fundAg>
      <fundAg>
                                            FONDATION ENTREPRISE MGEN SANTE PUBLIQUE (FSP MGEN)                    
                                    </fundAg>
      <fundAg>
                                            INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)                    
                                    </fundAg>
      <fundAg>
                                            MINISTERE DU TRAVAIL ET DES SOLIDARITES                    
                                    </fundAg>
    </prodStmt>
    <distStmt>
      <distrbtr abbr="null">
                    null</distrbtr>
      <contact affiliation="INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)" email="isabella.annesi-maesano@inserm.fr">
                    Isabella;ANNESI-MAESANO
                                            <ExtLink title="ROR" URI="https://ror.org/02vjkv261" role="organisation id"/>
                                            <ExtLink title="SIREN" URI="180036048" role="organisation id"/>
                                    </contact>
      <depDate date="2026-06-17"/>
      <distDate date="2026-06-17"/>
    </distStmt>
    <biblCit format="">
            </biblCit>
    <holdings URI="null"/>
    <notes> </notes>
  </citation>
  <stdyInfo>
    <studyBudget/>
    <subject>
      <keyword vocab="" vocabURI="">
                    skin test</keyword>
      <keyword vocab="" vocabURI="">
                    air pollution</keyword>
      <keyword vocab="" vocabURI="">
                    child</keyword>
      <keyword vocab="" vocabURI="">
                    environment</keyword>
      <keyword vocab="" vocabURI="">
                    allergy</keyword>
      <topcClas vocab="health theme">
                        Allergology                                                        <ExtLink title="ESV" URI="http://data.europa.eu/8mn/euroscivoc/af65e2bf-afc5-45e8-a0fc-364dfb48f0a4"/>
                                                            <ExtLink title="MeSH" URI="http://id.nlm.nih.gov/mesh/D000486"/>
                                                </topcClas>
      <topcClas vocab="health theme">
                        Paediatrics                                                        <ExtLink title="ESV" URI="http://data.europa.eu/8mn/euroscivoc/bf8aaaac-ddee-41cd-bb8a-c5a63de3fcbd"/>
                                                            <ExtLink title="MeSH" URI="http://id.nlm.nih.gov/mesh/D010372"/>
                                                </topcClas>
      <topcClas vocab="health determinant">
                        Behavioral determinants                    </topcClas>
      <topcClas vocab="health determinant">
                        Environmental determinants                    </topcClas>
      <topcClas vocab="health determinant">
                        Biological determinants: Genetic predisposition                    </topcClas>
      <topcClas vocab="health determinant">
                        Socio-demographic and economic determinants                    </topcClas>
      <topcClas vocab="health determinant">
                        Biological determinants                    </topcClas>
    </subject>
    <abstract contentType="purpose">To establish a global map of the prevalence of childhood allergic diseases and to determine the risk factors for these diseases by comparing contrasting population groups based on a particularly strong or weak prevalence. The ISAAC study consists of three phases: The objective of Phase I is to assess the prevalence of asthma, allergic rhinitis and eczema by using a simple questionnaire and possible video questionnaire (for asthma), in representative samples of children from two age groups: 13-14 years old (obligatory for all centres) and 6-7 years old (optional). Phase II aims to identify the risk factors and treatment procedures for allergic diseases through a more detailed study of selected population groups with relatively high or low prevalence rates suggested during Phase I. Phase III aims to assess the trends in allergy prevalence. As such, the Phase I protocol will be repeated in areas that participated in this phase.</abstract>
    <abstract contentType="abstract">null</abstract>
    <sumDscr>
      <collDate event="start" date="1999-01-01"/>
      <collDate event="end" date="2000-01-01"/>
      <nation abbr="bz">
                    Belize
                                            <concept vocab="ISO" vocabURI="bz"/>
                                    </nation>
      <nation abbr="cn">
                    China
                                            <concept vocab="ISO" vocabURI="cn"/>
                                    </nation>
      <nation abbr="de">
                    Germany
                                            <concept vocab="ISO" vocabURI="de"/>
                                    </nation>
      <nation abbr="it">
                    Italy
                                            <concept vocab="ISO" vocabURI="it"/>
                                    </nation>
      <nation abbr="fr">
                    France
                                            <concept vocab="ISO" vocabURI="fr"/>
                                    </nation>
      <nation abbr="jp">
                    Japan
                                            <concept vocab="ISO" vocabURI="jp"/>
                                    </nation>
      <nation abbr="kr">
                    Korea, Republic of
                                            <concept vocab="ISO" vocabURI="kr"/>
                                    </nation>
      <nation abbr="tw">
                    Taiwan, Province of China
                                            <concept vocab="ISO" vocabURI="tw"/>
                                    </nation>
      <nation abbr="ru">
                    Russian Federation
                                            <concept vocab="ISO" vocabURI="ru"/>
                                    </nation>
      <nation abbr="es">
                    Spain
                                            <concept vocab="ISO" vocabURI="es"/>
                                    </nation>
      <nation abbr="gb">
                    United Kingdom
                                            <concept vocab="ISO" vocabURI="gb"/>
                                    </nation>
      <nation abbr="us">
                    United States
                                            <concept vocab="ISO" vocabURI="us"/>
                                    </nation>
      <geogUnit/>
      <anlyUnit>
                Individuals            </anlyUnit>
      <universe level="type" clusion="I">General population                    </universe>
      <universe level="sex" clusion="I">Male                                                            <concept vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D008297"/>
                                                    </universe>
      <universe level="sex" clusion="I">Female                                                            <concept vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D005260"/>
                                                    </universe>
      <universe level="age" clusion="I">Child (6 to 12 years)                                                            <concept vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D002648"/>
                                                    </universe>
      <universe clusion="I">primary school children - between 8 and 13 years old                    </universe>
      <dataKind>Clinical data</dataKind>
      <dataKind>Participant-reported health data</dataKind>
      <dataKind>Biological data</dataKind>
      <dataKind>Paraclinical data (non-biological) : Anthropometry</dataKind>
    </sumDscr>
  </stdyInfo>
  <studyDevelopment>
    <developmentActivity type="primary evaluation">
      <description>Health event/morbidity</description>
    </developmentActivity>
  </studyDevelopment>
  <method>
    <dataColl>
      <timeMeth>One-time cross-sectional study</timeMeth>
      <sampProc>Other                                                            <concept vocab="CESSDA" vocabURI="Other"/>
                                                    </sampProc>
      <sampleFrame>
        <frameUnit>
          <unitType>Population database for statistical purposes</unitType>
        </frameUnit>
      </sampleFrame>
      <targetSampleSize>
        <sampleSizeFormula>[1000-10000[ individuals                        </sampleSizeFormula>
      </targetSampleSize>
      <collMode>Physical/biological measurements (blood pressure, weight, biochemistry, imaging, etc.)                                                            <concept vocab="CESSDA" vocabURI="MeasurementsAndTests.Physical"/>
                                                    </collMode>
    </dataColl>
    <notes>Observational Study</notes>
    <notes subject="research type">
                        Observational Study                    </notes>
    <anlyInfo>
      <respRate>Monde/World: 721 601 France: 7 432</respRate>
    </anlyInfo>
    <stdyClas>Completed study</stdyClas>
  </method>
  <dataAccs>
    <setAvail>
      <avlStatus>
                            Restricted access                                                    </avlStatus>
    </setAvail>
    <useStmt>
      <conditions>Contact the principal investigator</conditions>
    </useStmt>
  </dataAccs>
  <othrStdyMat>
    <relMat>Access on specific project only</relMat>
  </othrStdyMat>
</stdyDscr>
<dataDscr>
</dataDscr></codeBook>
