Longitudinal Study on Multimodal Imaging for Early-Stage Alzheimer's Disease: Biomarkers for Detection and Progression and Physiopathological Mechanisms FRESH-PEF7969-en Gaël CHETELAT Longitudinal Study on Multimodal Imaging for Early-Stage Alzheimer's Disease: Biomarkers for Detection and Progression and Physiopathological Mechanisms IMAP+ FRESH-PEF7969-en 7969 FRESH-PEF7969 Gaël CHETELAT CENTRE HOSPITALIER UNIVERSITAIRE DE CAEN NORMANDIE (CHU) Epidemiology France Portal (PEF) null Gaël;CHETELAT Genetics early diagnosis normal ageing neuroimaging PET MRI fMRI neuroanatomy molecular imaging FDG-PET Alzheimer's disease biomarkers AV45 Neurology Psychiatry Alzheimer disease Biological determinants: Genetic predisposition Behavioral determinants Biological determinants General objective: To study and compare the effectiveness of different in vivo markers to predict cognitive decline in patients at risk of developing Alzheimer's disease through neuroimaging, neuropsychology and biology measures. Secondary objectives: To study: i) Deterioration in NORMA subjects, as well as SCI, MCI, AD and SAND patients compared with healthy subjects of the same age; ii) Deterioration in E4 allele and apolipoprotein E (ApoE) carriers compared to non-carriers; iii) Cerebral and cognitive changes during normal ageing; iv) Progress and dynamics of different biomarkers during follow-up. To study the links between different deterioration profiles (intra-modality comparison and correlation), as well as differences in inter-group progression profiles. null France Individuals Patients population Male Female Young Adult (19 to 24 years) Adult (25 to 44 years) Middle Aged (45 to 64 years) Aged (65 to 79 years) Aged, 80 and over (80 years and more) Education level equal to 7 years or higher, native language is French, signed informed consent, medical, neurological and neuroimaging tests, as well as neuropsychological diagnostic test battery. Control subjects: normal performance according to age and education level in all diagnostic battery tests. Middle-aged (40-59 years old): no memory complaints. Elderly (aged 60+): living at home, independent, no memory complaints. NORMA (aged 18+) with identified disease, carriers of mutated gene associated with familial early-onset AD, normal performance according to age and education level in all diagnostic battery tests. Patients from memory assessment centres: SCI (aged 50+), no memory complaints, normal performance according to age and education level in all diagnostic battery tests. MCI meeting current amnestic MCI criteria with memory complaints, objective episodic memory deficits, performances in other cognitive functions where memory loss could occur, standard performance for age and education level in assessments of overall cognitive ability, independent in everyday life, no dementia according to DSM-IV criteria and no probable AD according to NINCDS-ADRDA criteria. Alzheimer's patients meeting NINCDS-ADRDA criteria for probable AD with abnormal overall cognitive function and deficits in at least 2 cognitive areas identified by diagnostic battery tests; mild- to moderate-stage AD; accompanying party's signed informed consent. SAND: CHU neurology departments - major episodic memory disorder that may be related to an objective deficit in executive function and standard performance for age and education level in all diagnostic battery tests measuring instrumental function. Clinical data Participant-reported health data Biological data Socio-demographic data Paraclinical data (non-biological) : Imaging NINCDS-ADRDA and DSM IV A diagnostic commission is organised on a monthly basis to report subject/patient neuropsychological results as well as their enrolment category on a case-by-case basis. A multimodal meeting is organised on a monthly basis to report quality control results for imaging data. This trial is monitored by a person appointed by the CHU to ensure that exact complete and reliable data is collected and to provide logistical support to research centres. Health event/morbidity Quality of life/health perception Other Through organizations (health services or institutions schools businesses etc.) Population database for statistical purposes < 500 individuals Recording (audio, video, electrophysiological, imaging) Observational Study Observational Study 280 Unknown To be defined Access on specific project only