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<docDscr>
  <citation>
    <titlStmt>
      <titl>Effective Perinatal Intensive Care in Europe</titl>
      <IDNo>FRESH-PEF7578-en</IDNo>
    </titlStmt>
    <prodStmt>
      <producer abbr="" affiliation="INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)" role="">Jennifer ZEITLIN</producer>
    </prodStmt>
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  </citation>
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<stdyDscr>
  <citation>
    <titlStmt>
      <titl>
                Effective Perinatal Intensive Care in Europe            </titl>
      <altTitl>
                    EPICE                </altTitl>
      <IDNo agency="FReSH-lang">
                FRESH-PEF7578-en            </IDNo>
      <IDNo agency="PEF">
                    7578                </IDNo>
      <IDNo agency="FReSH">
                    FRESH-PEF7578                </IDNo>
    </titlStmt>
    <rspStmt>
      <AuthEnty>
                    Jennifer ZEITLIN                                                                                                                            </AuthEnty>
      <AuthEnty affiliation="INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)">
        <ExtLink title="ROR" URI="https://ror.org/02vjkv261" role="organisation id"/>
        <ExtLink title="SIREN" URI="180036048" role="organisation id"/>
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    <prodStmt>
      <producer role="sponsor">
                                            INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)                    
                                    </producer>
      <prodPlac>
                Epidemiology France Portal (PEF)            </prodPlac>
      <fundAg>
                                            EUROPEAN COMMISSION RESEARCH                    
                                    </fundAg>
    </prodStmt>
    <distStmt>
      <distrbtr abbr="null">
                    null</distrbtr>
      <contact affiliation="INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)" email="jennifer.zeitlin@inserm.fr">
                    Jennifer;ZEITLIN
                                            <ExtLink title="ROR" URI="https://ror.org/02vjkv261" role="organisation id"/>
                                            <ExtLink title="SIREN" URI="180036048" role="organisation id"/>
                                    </contact>
      <depDate date="2026-06-17"/>
      <distDate date="2026-06-17"/>
    </distStmt>
    <biblCit format="">
            </biblCit>
    <holdings URI="null"/>
    <notes> </notes>
  </citation>
  <stdyInfo>
    <studyBudget/>
    <subject>
      <keyword vocab="" vocabURI="">
                    very preterm infants</keyword>
      <keyword vocab="" vocabURI="">
                    evidence based médicine</keyword>
      <keyword vocab="" vocabURI="">
                    neonatal intensive care. neurodevelopmental outcomes. follow-up at 2-5 years of age. european consortium.</keyword>
      <topcClas vocab="health theme">
                        Gynaecology and obstetrics                                                        <ExtLink title="ESV" URI="http://data.europa.eu/8mn/euroscivoc/7de64596-5b0d-4977-8f98-b982ff2ec17d"/>
                                                            <ExtLink title="ESV" URI="http://data.europa.eu/8mn/euroscivoc/284ca20c-beb4-4abe-99fa-ef4513358bad"/>
                                                            <ExtLink title="MeSH" URI="http://id.nlm.nih.gov/mesh/D006176"/>
                                                            <ExtLink title="MeSH" URI="http://id.nlm.nih.gov/mesh/D009774"/>
                                                </topcClas>
      <topcClas vocab="health theme">
                        Paediatrics                                                        <ExtLink title="ESV" URI="http://data.europa.eu/8mn/euroscivoc/bf8aaaac-ddee-41cd-bb8a-c5a63de3fcbd"/>
                                                            <ExtLink title="MeSH" URI="http://id.nlm.nih.gov/mesh/D010372"/>
                                                </topcClas>
      <topcClas vocab="health determinant">
                        Biological determinants: Genetic predisposition                    </topcClas>
      <topcClas vocab="health determinant">
                        Socio-demographic and economic determinants                    </topcClas>
      <topcClas vocab="health determinant">
                        Biological determinants                    </topcClas>
    </subject>
    <abstract contentType="purpose">To improve the survival and long-term health of very preterm infants by ensuring that medical knowledge is translated into effective perinatal care. To assess care provided in the first five years of life and neurodevelopmental outcomes at 2 and 5 years of age.</abstract>
    <abstract contentType="abstract">null</abstract>
    <sumDscr>
      <collDate event="start" date="2011-01-01"/>
      <collDate event="end" date="2014-01-01"/>
      <nation abbr="de">
                    Germany
                                            <concept vocab="ISO" vocabURI="de"/>
                                    </nation>
      <nation abbr="be">
                    Belgium
                                            <concept vocab="ISO" vocabURI="be"/>
                                    </nation>
      <nation abbr="dk">
                    Denmark
                                            <concept vocab="ISO" vocabURI="dk"/>
                                    </nation>
      <nation abbr="ee">
                    Estonia
                                            <concept vocab="ISO" vocabURI="ee"/>
                                    </nation>
      <nation abbr="fr">
                    France
                                            <concept vocab="ISO" vocabURI="fr"/>
                                    </nation>
      <nation abbr="it">
                    Italy
                                            <concept vocab="ISO" vocabURI="it"/>
                                    </nation>
      <nation abbr="nl">
                    Netherlands
                                            <concept vocab="ISO" vocabURI="nl"/>
                                    </nation>
      <nation abbr="pl">
                    Poland
                                            <concept vocab="ISO" vocabURI="pl"/>
                                    </nation>
      <nation abbr="pt">
                    Portugal
                                            <concept vocab="ISO" vocabURI="pt"/>
                                    </nation>
      <nation abbr="gb">
                    United Kingdom
                                            <concept vocab="ISO" vocabURI="gb"/>
                                    </nation>
      <nation abbr="se">
                    Sweden
                                            <concept vocab="ISO" vocabURI="se"/>
                                    </nation>
      <geogUnit/>
      <anlyUnit>
                Individuals            </anlyUnit>
      <universe level="type" clusion="I">General population                    </universe>
      <universe level="sex" clusion="I">Male                                                            <concept vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D008297"/>
                                                    </universe>
      <universe level="sex" clusion="I">Female                                                            <concept vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D005260"/>
                                                    </universe>
      <universe level="age" clusion="I">Infant, Newborn (birth to 28 days)                                                            <concept vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D007231"/>
                                                    </universe>
      <universe level="age" clusion="I">Infant (28 days to 2 years)                                                            <concept vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D007223"/>
                                                    </universe>
      <universe level="age" clusion="I">Child, Preschool (2 to 5 years)                                                            <concept vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D002675"/>
                                                    </universe>
      <universe clusion="I">very preterm infants born before 32 week of gestation                    </universe>
      <dataKind>Clinical data</dataKind>
      <dataKind>Participant-reported health data</dataKind>
    </sumDscr>
  </stdyInfo>
  <studyDevelopment>
    <developmentActivity type="primary evaluation">
      <description>Health event/morbidity
Health event/mortality
Health care consumption and services
Quality of life/health perception</description>
    </developmentActivity>
  </studyDevelopment>
  <method>
    <dataColl>
      <sampProc>Other                                                            <concept vocab="CESSDA" vocabURI="Other"/>
                                                    </sampProc>
      <sampleFrame>
        <frameUnit>
          <unitType>Through organizations (health services or institutions</unitType>
        </frameUnit>
        <frameUnit>
          <unitType>schools</unitType>
        </frameUnit>
        <frameUnit>
          <unitType>businesses</unitType>
        </frameUnit>
        <frameUnit>
          <unitType>etc.)</unitType>
        </frameUnit>
      </sampleFrame>
      <targetSampleSize>
        <sampleSizeFormula>[1000-10000[ individuals                        </sampleSizeFormula>
      </targetSampleSize>
      <collMode>Self-administered questionnaire                                                            <concept vocab="CESSDA" vocabURI="SelfAdministeredQuestionnaire"/>
                                                    </collMode>
      <collMode>Converting or copying information into a structured record                                                            <concept vocab="CESSDA" vocabURI="Transcription"/>
                                                    </collMode>
    </dataColl>
    <notes>Observational Study</notes>
    <notes subject="research type">
                        Observational Study                    </notes>
    <notes subject="observational study method">
                        Cohort study                    </notes>
    <anlyInfo>
      <respRate>10000 pregnancy. 6800 survival to discharge. 5000 follow-up at 2 or 5 years of age.</respRate>
    </anlyInfo>
    <stdyClas>Unknown</stdyClas>
  </method>
  <dataAccs>
    <setAvail>
      <avlStatus>
                            Restricted access                                                    </avlStatus>
    </setAvail>
    <useStmt>
      <conditions>Contact the website</conditions>
    </useStmt>
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  <othrStdyMat>
    <relMat>Access on specific project only</relMat>
  </othrStdyMat>
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<dataDscr>
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