{"doc_desc":{"title":"Etude B cube : Biobank and Brain health in Bordeaux","idno":"FRESH-PEF74145-fr","producers":[{"name":"C\u00e9cilia SAMIERI","affiliation":"INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)"}]},"study_desc":{"title_statement":{"idno":"FRESH-PEF74145-fr","IDno":{"metadata_no":[{"agency":"PEF","code":"74145"},{"agency":"FReSH","code":"FRESH-PEF74145"}]},"title":"Etude B cube : Biobank and Brain health in Bordeaux","alternate_title":"B cube"},"study_authorization":{"agency":[{"name":"CNIL"}]},"authoring_entity":[{"name":"Coralie;DELGADO","firstname":"Coralie","lastname":"DELGADO","type":"investigator","extlink":[{"title":"ROR","uri":"https:\/\/ror.org\/02vjkv261","role":"organisation id"},{"title":"SIREN","uri":"180036048","role":"organisation id"}],"email":"coralie.delgado@u-bordeaux.fr","affiliationName":"INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)","PILabo":"INSERM \/ Bordeaux Population health research center INSERM U1219","isContact":true}],"oth_id":[{"name":"Etude financ\u00e9e dans le cadre du PIA3 (PSPC BPI France, projet \"SilverBrainFood\")","type":"collaboration"}],"production_statement":{"prod_place":"Portail Epid\u00e9miologie France (PEF)","producers":[{"name":"CENTRE HOSPITALIER UNIVERSITAIRE DE BORDEAUX","extlink":[{"title":"ROR","uri":"https:\/\/ror.org\/01hq89f96","role":"sponsor id"},{"title":"SIREN","uri":"263305823","role":"sponsor id"}],"role":"sponsor"}],"funding_agencies":[{"name":"PSPC BPI France"}]},"distribution_statement":{"contact":[{"name":"Coralie;DELGADO","lastname":"DELGADO","firstname":"Coralie","type":"contact","email":"coralie.delgado@u-bordeaux.fr","affiliationName":"INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)","contactPointLabo":"","extlink":[{"uri":"https:\/\/ror.org\/02vjkv261","role":"organisation id","title":"ROR"},{"uri":"180036048","role":"organisation id","title":"SIREN"}]},{"name":"C\u00e9cilia;SAMIERI","lastname":"SAMIERI","firstname":"C\u00e9cilia","type":"contact","email":"cecilia.samieri@u-bordeaux.fr","affiliationName":"INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)","contactPointLabo":"","extlink":[{"uri":"https:\/\/ror.org\/02vjkv261","role":"organisation id","title":"ROR"},{"uri":"180036048","role":"organisation id","title":"SIREN"}]}]},"study_info":{"keywords":[{"keyword":"exposome"}],"topics":[{"topic":"G\u00e9riatrie","vocab":"health theme","extLink":[{"title":"ESV","uri":"http:\/\/data.europa.eu\/8mn\/euroscivoc\/d37e4d8c-a978-40c7-ba4f-eee841851073"},{"title":"MeSH","uri":"http:\/\/id.nlm.nih.gov\/mesh\/D005853"}]},{"topic":"Neurologie","vocab":"health theme","extLink":[{"title":"ESV","uri":"http:\/\/data.europa.eu\/8mn\/euroscivoc\/c4793dfe-e80e-49dd-9fcc-a1a742de1b25"},{"title":"ESV","uri":"http:\/\/data.europa.eu\/8mn\/euroscivoc\/00a5c4f4-b7ee-41a4-bcdf-3a02e6be1660"},{"title":"MeSH","uri":"http:\/\/id.nlm.nih.gov\/mesh\/D009462"}]},{"topic":"Maladie d'Alzheimer","vocab":"cim-11","extLink":[{"uri":"http:\/\/id.who.int\/icd\/entity\/1611724421","title":"CIM-11"}]},{"topic":"D\u00e9terminants socio-d\u00e9mographiques et \u00e9conomiques","vocab":"health determinant"},{"topic":"D\u00e9terminants comportementaux","vocab":"health determinant"},{"topic":"D\u00e9terminants comportementaux : Alimentation","vocab":"health determinant"},{"topic":"D\u00e9terminants environnementaux","vocab":"health determinant"}],"purpose":"Etude de l'exposome du vieillissement c\u00e9r\u00e9bral aux stades pr\u00e9coces. R\u00e9sum\u00e9 : les maladies c\u00e9r\u00e9brales li\u00e9es \u00e0 l\u2019\u00e2ge comme la maladie d\u2019Alzheimer \u00e9voluent silencieusement durant 15 \u00e0 20 ans dans le cerveau avant la manifestation des premiers sympt\u00f4mes et le diagnostic et \u00e0 ce jour, on conna\u00eet encore mal les facteurs qui concourent au d\u00e9clenchement de la maladie. Une partie de ces facteurs, non modifiable, est li\u00e9e au terrain g\u00e9n\u00e9tique ; une autre partie, elle modifiable, est due \u00e0 l\u2019exposome, c\u2019est-\u00e0-dire \u00e0 l\u2019ensemble des expositions auxquelles chacun est soumis et qui influencent notre sant\u00e9. Cela inclut les expositions ext\u00e9rieures (alimentation, polluants, etc.), mais aussi le contexte social, ainsi que les r\u00e9gulations du milieu int\u00e9rieur (biologiques). Afin de d\u00e9crypter le r\u00f4le de cette part environnementale dans le vieillissement du cerveau aux stades les plus pr\u00e9coces, l\u2019\u00e9quipe ELEANOR du BPH Inserm U1219 a lanc\u00e9 en Mars 2022, avec le soutien du PIA3, une nouvelle \u00e9tude en population, la cohorte B cube. L\u2019objectif est d\u2019inclure 2 000 jeunes s\u00e9niors (\u00e0 partir de 55 ans) volontaires de la M\u00e9tropole de Bordeaux pour analyser de mani\u00e8re pluridisciplinaire leurs comportements, leurs param\u00e8tres biologiques, leur microbiote, etc., et les mettre en lien avec leur fonctionnement c\u00e9r\u00e9bral. L\u2019ambition est d\u2019identifier les facteurs et les m\u00e9canismes qui, t\u00f4t dans la vie, permettent au cerveau de s\u2019adapter au vieillissement ou, au contraire, de mener au d\u00e9veloppement de pathologies du vieillissement c\u00e9r\u00e9bral. L\u2019\u00e9quipe compte ainsi d\u00e9finir des strat\u00e9gies de pr\u00e9vention pr\u00e9coce, susceptibles de retarder ou d\u2019\u00e9viter ces maladies en esp\u00e9rant, \u00e0 terme, diminuer le fardeau du vieillissement c\u00e9r\u00e9bral sur la soci\u00e9t\u00e9.","abstract":"","coll_dates":[{"start":"2022-01-01"}],"nation":[{"name":"France","abbreviation":"fr","extLink":{"vocab":"ISO","vocabURI":"fr"}}],"geog_coverage":"['Nouvelle-Aquitaine']","analysis_unit":"Individus","universe":"{\n    \"level_sex_clusion_I\": [\n        {\n            \"value\": \"Masculin\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D008297\"\n            }\n        },\n        {\n            \"value\": \"F\u00e9minin\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D005260\"\n            }\n        },\n        {\n            \"value\": \"Autre\",\n            \"concept\": {\n                \"vocab\": [],\n                \"vocabURI\": []\n            }\n        }\n    ],\n    \"level_age_clusion_I\": [\n        {\n            \"value\": \"Adulte (45 \u00e0 64 ans)\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D008875\"\n            }\n        },\n        {\n            \"value\": \"Personne \u00e2g\u00e9e (65 \u00e0 79 ans)\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D000368\"\n            }\n        }\n    ],\n    \"level_type_clusion_I\": \"Population g\u00e9n\u00e9rale\",\n    \"level_type_clusion_other\": \"\",\n    \"clusion_I\": \"Etre \u00e2g\u00e9 entre 55 et 80 ans, vivre dans Bordeaux ou sa m\u00e9tropole (non institutionnalis\u00e9) et accepter le pr\u00e9l\u00e8vement sanguin.\",\n    \"clusion_E\": \"\"\n}","data_kind":"['Donn\u00e9es cliniques','Donn\u00e9es rapport\u00e9es par le participant de l'\u00e9tude','Donn\u00e9es paracliniques','Donn\u00e9es biologiques','Donn\u00e9es paracliniques (hors biologiques) : Anthropom\u00e9trie','Donn\u00e9es paracliniques (hors biologiques) : Exploration fonctionnelle']","quality_statement":{"standards":[{"name":"","committee":"","governance":""}],"other_quality_statement":"['plateforme EPICONCEPT']"}},"study_development":{"development_activity":[{"activity_type":"primary evaluation","activity_description":"Ev\u00e9nements de sant\u00e9\/morbidit\u00e9\r\nAutres"}]},"method":{"data_collection":{"time_method":"","frequency":"","sampling_procedure":"['{\"concept\":{\"vocabURI\":\"Other\",\"vocab\":\"CESSDA\"},\"value\":\"Autre\"}']","sample_frame":{"frame_unit":{"unit_type":"['Base de population \u00e0 finalit\u00e9 statistique']"}},"coll_mode":["{\"concept\":{\"vocabURI\":\"SelfAdministeredQuestionnaire\",\"vocab\":\"CESSDA\"},\"value\":\"Questionnaire auto-administr\u00e9\"}","{\"concept\":{\"vocabURI\":\"Interview\",\"vocab\":\"CESSDA\"},\"value\":\"Entretien avec le participant (dont clinique)\"}"],"research_instrument":"","sources":[],"target_sample_size":"[1000-10000[ individus","response_rate":"Cible 2000 participants"},"method_notes":"Etude observationnelle","study_class":"Inconnu","notes":[{"subject":"research type","values":["Etude observationnelle"]},{"subject":"observational study method","values":["Cohorte"]}]},"data_access":{"dataset_availability":{"access_place":"","complete":"","status":"{\"value\":\"A 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Les donn\u00e9es environnementales pr\u00e9alablement receuillies par autoquestionnaire (calendriers r\u00e9sidentiels et professionnels) sont syst\u00e9matiquement reprises et compl\u00e9t\u00e9es par enqu\u00eate t\u00e9l\u00e9phonique.","collectionModeOther":""},"dataCollection":{"inclusionStrategyOther":"","samplingModeOther":"","recruitmentSourceOther":"","otherDocumentation":""},"dataCollectionIntegration":{"isDataIntegration":false},"geographicalCoverage":{"geoDetail":"Bordeaux m\u00e9tropole"},"dataTypes":{"clinicalDataDetails":"Ant\u00e9c\u00e9dents m\u00e9dicaux et neurologiques; d\u00e9pistage troubles moteurs et parkinsoniens; plaintes cognitive subjectives; bilan neuropsychologique complet : batterie de tests cognitifs (cliniques : MMSE, IST, FCSRT; 4 tests de la batterie informatis\u00e9e CANTAB (Alzheimer); CDR-SOB; impression clinique; \u00e9chelles de d\u00e9pression et anxi\u00e9t\u00e9, etc.","biologicalDataDetails":"Biobanque compl\u00e8te : sang, urines (pool hebdomadaire de 6 pr\u00e9l\u00e8vements matin\/soir), selles, salive, cheveux, ongles, pr\u00e9l\u00e8vement nasal.","isDataInBiobank":true,"biobankContent":[],"biobankContentOther":"","dataTypeOther":""},"variableDictionnary":{"variableDictionnaryAvailable":"","variableDictionnaryLink":""},"dataQuality":{"otherDocumentation":""},"mockSample":{"mockSampleAvailable":"","mockSampleLocation":""},"thirdPartySource":{"otherSourceType":[]},"isHealthTheme":true,"fileDscr":{"fileTxt":{"fileCitation":{"titlStmt":{"IDno":[]}}}}},"schematype":"survey"}