Prospective cohort study on the impact of insulin resistance on sustained virological response to Pegasys® and Copegus® treatment in patients with Chronic Hepatitis-C FRESH-PEF74113-en Camille BACHOT Prospective cohort study on the impact of insulin resistance on sustained virological response to Pegasys® and Copegus® treatment in patients with Chronic Hepatitis-C ORPHEE FRESH-PEF74113-en 74113 FRESH-PEF74113 NCT01200225 F. HOFFMANN-LA ROCHE AG Epidemiology France Portal (PEF) null ;Medical data center Copegus® treatment Infectious disease medicine Viral hepatitis Healthcare system determinants: Use of care Healthcare system determinants Primary objective : To describe in real-life conditions the insulin resistance and its impact on SVR in patients presenting with chronic hepatitis C and treated with Pegasys® and Copegus®. Secondary objectives : - To describe patients’ characteristics at inclusion - To describe the predictive factors influencing virological response under treatment at W4 (rapid virological response, RVR), at W12 (early virological response, EVR), and 24 weeks after the end of treatment with Pegasys® (sustained virological response, SVR) - To describe the constitutive parameters of metabolic syndrome during the study period - To describe the management of chronic hepatitis C and insulin resistance - To describe the changes in patients’ quality of life during the study period - To describe the serious and non-serious adverse events occurring during the study period. null France Individuals Patients population Male Female Young Adult (19 to 24 years) Adult (25 to 44 years) Middle Aged (45 to 64 years) Aged (65 to 79 years) Aged, 80 and over (80 years and more) Inclusion criteria : - Adult patient (age >=18 years) - Suffering from chronic hepatitis C (detectable blood HCV RNA) - For whom the specialist had decided to initiate dual therapy with Pegasys® and Copegus® - Who received both oral and written information about the study, without any objections for the use of his/her personal data. Clinical data GCP/GVP Other Through organizations (health services or institutions schools businesses etc.) [1000-10000[ individuals Converting or copying information into a structured record Interview with the participant (including clinical) Observational Study Observational Study Cohort study 1150 Unknown Restricted access Access on specific project only