Therapeutic management of adult or child patients with hemophilia A : A retrospective observational study - HEMONIS study FRESH-PEF74089-en Camille BACHOT Therapeutic management of adult or child patients with hemophilia A : A retrospective observational study - HEMONIS study HEMONIS FRESH-PEF74089-en 74089 FRESH-PEF74089 F. HOFFMANN-LA ROCHE AG Epidemiology France Portal (PEF) null ;Medical data center emicizumab Hematology Hereditary factor VIII deficiency Healthcare system determinants: Use of care Healthcare system determinants Primary Objective: To describe the current therapeutic regimen for moderate and severe HA patients (ITI / on-demand / short-term prophylaxis / long-term prophylaxis) in the MS population. Secondary Objectives: - To describe the current therapeutic regimen (ITI / on-demand / short-term prophylaxis / long-term prophylaxis) in severe HA patients in the Sev population. In both Moderate or Severe (MS) population and Severe (Sev) population : - To describe the profile of patients with HA - To describe the current treatment type according to therapeutic regimen, inhibitors status and severity - To describe patient status regarding medical conditions and disease characteristics (severity, presence of inhibitors) - To describe the patient’s musculoskeletal complications In Severe (Sev) population: - To describe medical history and related conditions - To describe thrombosis events - To describe therapeutic management administered to patients with severe HA from January 1, 2000 to the last visit (therapeutic regimens in the 2 years preceding the index date , therapeutic regimen from January 1, 2000 until 2 years preceeding the last visit) - To describe ITI prescribed treatment from initial diagnosis - To describe significant events (bleeding) or prevention of physical activities and their management occurring in the 2 years preceeding the last visit. - To describe all surgeries occurring in the 2 years preceeding the last visit. Exploratory Objectives: - To identify factors associated with choice of therapeutic regimen (on-demand vs prophylaxis) in the Sev population with inhibitors status at last visit: “Never inhibitor” or “Tolerized inhibitor”. - To identify factors associated with choice of therapeutic regimen (Prophylaxis vs on-demand, ITI vs on-demand) in the Sev population with inhibitors status at last visit: “Current inhibitor” . - To identify factors associated with choice of ITI regimen (no ITI vs ITI) in the Sev population among patients with inhibitors. null France Individuals Patients population Male Female Child (6 to 12 years) Young Adult (19 to 24 years) Adult (25 to 44 years) Middle Aged (45 to 64 years) Aged (65 to 79 years) Aged, 80 and over (80 years and more) Inclusion criteria: o Patient aged ≥ 5 years old o Patient with moderate or severe constitutional o Patient with a last visit within the last 2 years o Patient followed in the same center for 2 years previous to the last visit, or patient followed in the same center from initial diagnosis, whichever is the shortest as collected in eCRF o Patient who has received written information and expressed his/her refusal to participate in the study, or minor patient for whom at least one parent or guardian has expressed a refusal to participate in the study as checked by programming (patients without information date) o Patient included in a clinical trial at the date of last visit as collected in eCRF Clinical data Participant-reported health data CDISC like GCP/GVP Other Through independent healthcare practitioners < 500 individuals Converting or copying information into a structured record Observational Study Observational Study Cohort study 430 Unknown Restricted access Access on specific project only