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<docDscr>
  <citation>
    <titlStmt>
      <titl>Multicenter study on nosocomial transmission of SARS-CoV2 virus - Ancillary study of NOSO-COR Project</titl>
      <IDNo>FRESH-PEF73994-en</IDNo>
    </titlStmt>
    <prodStmt>
      <producer abbr="" affiliation="UNIVERSITE CLAUDE BERNARD LYON 1" role="">PHILIPPE VANHEMS</producer>
    </prodStmt>
    <verStmt>
      <version></version>
    </verStmt>
  </citation>
</docDscr>
<stdyDscr>
  <citation>
    <titlStmt>
      <titl>
                Multicenter study on nosocomial transmission of SARS-CoV2 virus - Ancillary study of NOSO-COR Project            </titl>
      <altTitl>
                    NOSO-COR-IMMUNO                </altTitl>
      <IDNo agency="FReSH-lang">
                FRESH-PEF73994-en            </IDNo>
      <IDNo agency="PEF">
                    73994                </IDNo>
      <IDNo agency="FReSH">
                    FRESH-PEF73994                </IDNo>
    </titlStmt>
    <rspStmt>
      <AuthEnty>
                    Philippe VANHEMS                                                                                                                            </AuthEnty>
      <AuthEnty affiliation="UNIVERSITE CLAUDE BERNARD LYON 1">
        <ExtLink title="ROR" URI="https://ror.org/029brtt94" role="organisation id"/>
        <ExtLink title="SIREN" URI="196917744" role="organisation id"/>
      </AuthEnty>
      <othId affiliation="" type="">
                                    </othId>
    </rspStmt>
    <prodStmt>
      <producer role="sponsor">
                                            HOSPICES CIVILS DE LYON (HCL)                    
                                    </producer>
      <prodPlac>
                Epidemiology France Portal (PEF)            </prodPlac>
    </prodStmt>
    <distStmt>
      <distrbtr abbr="null">
                    null</distrbtr>
      <contact affiliation="UNIVERSITE CLAUDE BERNARD LYON 1" email="philippe.vanhems@chu-lyon.fr">
                    Philippe;VANHEMS
                                            <ExtLink title="ROR" URI="https://ror.org/029brtt94" role="organisation id"/>
                                            <ExtLink title="SIREN" URI="196917744" role="organisation id"/>
                                    </contact>
      <depDate date="2026-06-17"/>
      <distDate date="2026-06-17"/>
    </distStmt>
    <biblCit format="">
            </biblCit>
    <holdings URI="null"/>
    <notes> </notes>
  </citation>
  <stdyInfo>
    <studyBudget/>
    <subject>
      <topcClas vocab="health theme">
                        Infectious disease medicine                                                        <ExtLink title="ESV" URI="http://data.europa.eu/8mn/euroscivoc/fa2ceeab-3b2f-45e9-9243-e5a8005b98de"/>
                                                            <ExtLink title="MeSH" URI="http://id.nlm.nih.gov/mesh/D055552"/>
                                                </topcClas>
      <topcClas vocab="cim-11">
                        Certain infectious or parasitic diseases                                            </topcClas>
      <topcClas vocab="cim-11">
                        COVID-19                                            </topcClas>
    </subject>
    <abstract contentType="purpose">The main objective of this ancillary study is to describe the serological response in people infected with SARS-CoV-2 at a distance from the infectious episode. Secondary objectives : 1. Characterization of virus-specific CD8 T populations, phenotype and functional capacity, present in circulation (PBL) 2. Titration of neutralizing vs. facilitating antibodies 3. Comparison of patient memory immune response characteristics 4. Study of post-COVID19 immune restoration 5. Establishment of a collection of biological salivary and blood samples at HCL (serum and peripheral blood mononuclear cells (PBMC)) and transfer of part of the blood products before the end of the research to the Centre International de Recherche en Infectiologie (CIRI) to initiate research for new scientific knowledge on SARS-CoV-2 pathogens</abstract>
    <abstract contentType="abstract">null</abstract>
    <sumDscr>
      <collDate event="start" date="2020-01-01"/>
      <collDate event="end" date="2021-01-01"/>
      <nation abbr="fr">
                    France
                                            <concept vocab="ISO" vocabURI="fr"/>
                                    </nation>
      <geogCover>Auvergne Rhône-Alpes</geogCover>
      <geogUnit/>
      <anlyUnit>
                Individuals            </anlyUnit>
      <universe level="type" clusion="I">Patients population                    </universe>
      <universe level="sex" clusion="I">Male                                                            <concept vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D008297"/>
                                                    </universe>
      <universe level="sex" clusion="I">Female                                                            <concept vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D005260"/>
                                                    </universe>
      <universe level="age" clusion="I">Adult (25 to 44 years)                                                            <concept vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D000328"/>
                                                    </universe>
      <universe level="age" clusion="I">Middle Aged (45 to 64 years)                                                            <concept vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D008875"/>
                                                    </universe>
      <universe level="age" clusion="I">Aged (65 to 79 years)                                                            <concept vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D000368"/>
                                                    </universe>
      <universe level="age" clusion="I">Aged, 80 and over (80 years and more)                                                            <concept vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D000369"/>
                                                    </universe>
      <dataKind>Clinical data</dataKind>
      <dataKind>Participant-reported health data</dataKind>
      <dataKind>Biological data</dataKind>
      <dataKind>Socio-demographic data</dataKind>
    </sumDscr>
    <qualityStatement>
      <otherQualityStatement>Data collected by doctors in face-to-face interviews</otherQualityStatement>
      <otherQualityStatement>entered by Prof. Vanhems\' epidemiology team in an e-CRF created by HCL data managers. Data analysed by the HCL biostatistics team.</otherQualityStatement>
    </qualityStatement>
  </stdyInfo>
  <method>
    <dataColl>
      <sampProc>Other                                                            <concept vocab="CESSDA" vocabURI="Other"/>
                                                    </sampProc>
      <sampleFrame>
        <frameUnit>
          <unitType>Through organizations (health services or institutions</unitType>
        </frameUnit>
        <frameUnit>
          <unitType>schools</unitType>
        </frameUnit>
        <frameUnit>
          <unitType>businesses</unitType>
        </frameUnit>
        <frameUnit>
          <unitType>etc.)</unitType>
        </frameUnit>
      </sampleFrame>
      <collMode>Physical/biological measurements (blood pressure, weight, biochemistry, imaging, etc.)                                                            <concept vocab="CESSDA" vocabURI="MeasurementsAndTests.Physical"/>
                                                    </collMode>
    </dataColl>
    <notes>Observational Study</notes>
    <notes subject="research type">
                        Observational Study                    </notes>
    <anlyInfo>
      <respRate>189</respRate>
    </anlyInfo>
    <stdyClas>Unknown</stdyClas>
  </method>
  <dataAccs>
    <setAvail>
      <avlStatus>
                            Restricted access                                                    </avlStatus>
    </setAvail>
  </dataAccs>
</stdyDscr>
<dataDscr>
</dataDscr></codeBook>
