Comparison of strategies based on RT-PCR or antigenic testing for screening for SARS-CoV-2 infection in the general population from self-samples. FRESH-PEF73973-en Amandine BAUDOT Comparison of strategies based on RT-PCR or antigenic testing for screening for SARS-CoV-2 infection in the general population from self-samples. AutoCoV FRESH-PEF73973-en 73973 FRESH-PEF73973 Julie GAGNAIRE Bruno POZZETTO CENTRE HOSPITALIER UNIVERSITAIRE DE SAINT-ETIENNE Epidemiology France Portal (PEF) null Julie;GAGNAIRE Bruno;POZZETTO Infectious disease medicine COVID-19 The main objective is to evaluate, for the screening of SARSCoV-2 infection, the performance of a strategy that would combine 1) a salivary self-sampling associated with a previous nasal self-sampling and 2) an antigenic diagnostic test that can be directly performed in the field, in comparison with the reference technique of RT-PCR on salivary samples recently validated by the HAS. ; Secondary objectives:; - Determine the prevalence of SARS-CoV-2 infection in the population tested by the reference test ;; - Determine the prevalence of circulation of the different SARS-CoV-2 variants of interest in the population tested ;; - Evaluate the acceptability of self-sampling as a function of age and socio-professional category;; - Evaluate the feasibility of the two screening strategies;; - Evaluate the cost-effectiveness of the new diagnostic strategy compared with the reference technique (RT-PCR on saliva);; - Reinforce adherence to barrier measures and instructions for early isolation of positive cases, by means of rapid tests and support from people trained in the motivational approach;; - Evaluate health support for people in isolation;; - Evaluate, on a sample of positive and negative test subjects, knowledge of barrier measures and isolation instructions, through the use of rapid tests and support from anti-COVID mediators. null France Auvergne Rhône-Alpes Individuals General population Male Female Child (6 to 12 years) Young Adult (19 to 24 years) Adult (25 to 44 years) Middle Aged (45 to 64 years) Aged (65 to 79 years) Aged, 80 and over (80 years and more) Participant-reported health data Biological data Repeated cross-sectional study Other Through independent healthcare practitioners Through organizations (health services or institutions schools businesses etc.) Converting or copying information into a structured record Interview with the participant (including clinical) Observational Study Observational Study 7100 Unknown To be defined