Study of the Serological Response Against the SARS-CoV-2 Virus in 2 Types of Employees, Hospital and Non-hospital, at Institute Curie and Institute Pasteur FRESH-PEF73954-en Study of the Serological Response Against the SARS-CoV-2 Virus in 2 Types of Employees, Hospital and Non-hospital, at Institute Curie and Institute Pasteur Curiosa FRESH-PEF73954-en 73954 FRESH-PEF73954 NCT04369066 Olivier LANTZ Thierry ROSE INSTITUT CURIE Epidemiology France Portal (PEF) null Olivier;LANTZ Clinical immunology Infectious disease medicine COVID-19 Behavioral determinants Healthcare system determinants: Use of care Healthcare system determinants The aim of this study is to set up a prospective serobank to study the prevalence and quality of the serological immune response directed against the SARS-CoV-2 virus during the pandemic in an active population without any acute episode of SARS-CoV-2 infection, i.e. Institut Curie employees (Headquarters, Hospital and Research Centre) and Institut Pasteur employees with potentially varying levels of exposure. null France Ile-de-France Individuals General population Male Female Young Adult (19 to 24 years) Adult (25 to 44 years) Middle Aged (45 to 64 years) 1) Person, adult volunteer outside of any acute infectious episode with SARS-CoV-2* (see paragraph indication), working at the Institute Curie and able to exercise their professional activity on one of the 3 sites of the Institute Curie: Paris, Orsay or Saint Cloud, or on the Campus of the Institute Pasteur. 2) Person aged 18 or over. 3) Information and consent of the person to the procedures related to the study (cf. information note / consent). 4) From November 2020, person having presented at least one of the following criteria since January 2020: – A positive diagnostic test for SARS-COV-2 by PCR on a nasopharyngeal sample or antigenic test, – A positive SARS-CoV-2 serology, – An anosmia or / and an ageusia, – A respiratory infection ** associated with digestive signs ** For employees of Institut Pasteur, whatever the working methods during confinement: Person having presented at least one of the following criteria since January 2020: – A positive diagnostic test for SARS-COV-2 by PCR on a nasopharyngeal sample, – A positive SARS-CoV-2 serology, – An anosmia or / and an ageusia, – A respiratory infection ** associated with digestive signs ** *Subjects who are not showing active SARS-CoV-2 infection are considered volunteers at the time of inclusion: people with no clinical signs ** suggestive of SARS-CoV-2 infection at the time of collection or having had an end of symptoms for more than 7 days. **fever, fatigue, cough, shortness of breath, difficulty to breath, loss of taste or smell, headache, body aches, conjunctivitis or cold, digestive problems (vomiting, diarrhea), whether or not the signs led to sick leave, treatment and / or hospitalization. Participant-reported health data Biological data Health event/morbidity Other Through independent healthcare practitioners [1000-10000[ individuals Converting or copying information into a structured record Interview with the participant (including clinical) Observational Study Observational Study Cohort study 1900 Unknown Restricted access Access on specific project only