{"doc_desc":{"title":"Frailty in people living with HIV aged 70 and over: feasibility of screening for frailty, prevalence, risk factors and impact on the occurrence of adverse health events","idno":"FRESH-PEF73421-en","producers":[{"name":"Mariem RAHO","affiliation":"INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)"}]},"study_desc":{"title_statement":{"idno":"FRESH-PEF73421-en","IDno":{"metadata_no":[{"agency":"PEF","code":"73421"},{"agency":"FReSH","code":"FRESH-PEF73421"}]},"title":"Frailty in people living with HIV aged 70 and over: feasibility of screening for frailty, prevalence, risk factors and impact on the occurrence of adverse health events","alternate_title":"ANRS EP66 SEPTAVIH"},"study_authorization":{"agency":[]},"authoring_entity":[{"name":"Laurence;SLAMA","firstname":"Laurence","lastname":"SLAMA","type":"investigator","extlink":[{"title":"ROR","uri":"https:\/\/ror.org\/00pg5jh14","role":"organisation 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MONTPELLIER (CHU)","contactPointLabo":"","extlink":[{"uri":"https:\/\/ror.org\/00mthsf17","role":"organisation id","title":"ROR"},{"uri":"263400160","role":"organisation id","title":"SIREN"}]},{"name":"Clotilde;ALLAVENA","lastname":"ALLAVENA","firstname":"Clotilde","type":"contact","email":"clotilde.allavena@chu-nantes.fr","affiliationName":"CENTRE HOSPITALIER UNIVERSITAIRE DE NANTES","contactPointLabo":"","extlink":[{"uri":"https:\/\/ror.org\/05c1qsg97","role":"organisation id","title":"ROR"},{"uri":"264400136","role":"organisation id","title":"SIREN"}]},{"name":"Laurence;MEYER","lastname":"MEYER","firstname":"Laurence","type":"contact","email":"laurence.meyer@inserm.fr","affiliationName":"INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)","contactPointLabo":"","extlink":[{"uri":"https:\/\/ror.org\/02vjkv261","role":"organisation id","title":"ROR"},{"uri":"180036048","role":"organisation 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determinants","vocab":"health determinant"},{"topic":"Healthcare system determinants","vocab":"health determinant"}],"purpose":"To evaluate the prevalence of frailty according to Fried's criteria in people living with HIV aged 70 and over Secondary objectives: To study and describe frailty in PLHIV aged 70 and over according to different indexes: Fried, Cumulative Deficit Index, HAS score, VACS index Study the association between frailty and various parameters specific to HIV infection and other non-specific parameters Identify factors associated with frailty at M0 and with progression or regression of frailty during 12 months of follow-up Study the occurrence of adverse health events during the 12 months of follow-up (falls, emergency room visits, hospitalisations, institutionalisation, loss of an iADL point, death) Evaluate the prevalence of sarcopenia and osteoporosis Describe the population (socio-demographic characteristics, socio-economic level, HIV infection and treatment history, comorbidities, polymedication, mental health, quality of life, etc.) Study inflammatory and immunosenescence markers at M0","abstract":"","coll_dates":[{"start":"2019-01-01","end":"2021-01-01"}],"nation":[{"name":"France","abbreviation":"fr","extLink":{"vocab":"ISO","vocabURI":"fr"}}],"geog_coverage":"","analysis_unit":"Individuals","universe":"{\n    \"level_sex_clusion_I\": [\n        {\n            \"value\": \"Male\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D008297\"\n            }\n        },\n        {\n            \"value\": \"Female\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D005260\"\n            }\n        },\n        {\n            \"value\": \"Other\",\n            \"concept\": {\n                \"vocab\": [],\n                \"vocabURI\": []\n            }\n        }\n    ],\n    \"level_age_clusion_I\": [\n        {\n            \"value\": \"Aged (65 to 79 years)\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D000368\"\n            }\n        },\n        {\n            \"value\": \"Aged, 80 and over (80 years and more)\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D000369\"\n            }\n        }\n    ],\n    \"level_type_clusion_I\": \"Patients population\",\n    \"level_type_clusion_other\": \"\",\n    \"clusion_I\": \"\",\n    \"clusion_E\": \"\"\n}","data_kind":"['Clinical data','Participant-reported health data','Biological data','Paraclinical data (non-biological) : Imaging']","quality_statement":{"standards":[{"name":"['ATC for drugs, ICD10 for cause of death']","committee":"","governance":""}],"other_quality_statement":"['Risk-based monitoring (on-site 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Clinical Immunology, H\u00f4tel Dieu Hospital, APHP Infectious Diseases, Piti\u00e9 Salp\u00e9tri\u00e8re Hospital, APHP Infectious Diseases, Martinique University Hospital Infectious Diseases Day Care Unit, St Andr\u00e9 Hospital, Bordeaux Infectious Diseases, Pellegrin Hospital, Bordeaux Infectious Diseases CHU de Montpellier, Infectious Diseases CHU de Nantes, Infectious Diseases CHU de Nice, Infectious Diseases CHU Pontchaillou Rennes, HIV Care Centre CHU de Strasbourg, Infectious Diseases CHU de Grenoble Alpes, Diagnostic and Therapeutic Centre H\u00f4tel Dieu Paris AP-HP"},"dataTypes":{"clinicalDataDetails":"","biologicalDataDetails":"Immunovirologic, hematologic, biochemical and metabolic 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