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<docDscr>
  <citation>
    <titlStmt>
      <titl>Frailty in people living with HIV aged 70 and over: feasibility of screening for frailty, prevalence, risk factors and impact on the occurrence of adverse health events</titl>
      <IDNo>FRESH-PEF73421-en</IDNo>
    </titlStmt>
    <prodStmt>
      <producer abbr="" affiliation="INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)" role="">Mariem RAHO</producer>
    </prodStmt>
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      <version></version>
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<stdyDscr>
  <citation>
    <titlStmt>
      <titl>
                Frailty in people living with HIV aged 70 and over: feasibility of screening for frailty, prevalence, risk factors and impact on the occurrence of adverse health events            </titl>
      <altTitl>
                    ANRS EP66 SEPTAVIH                </altTitl>
      <IDNo agency="FReSH-lang">
                FRESH-PEF73421-en            </IDNo>
      <IDNo agency="PEF">
                    73421                </IDNo>
      <IDNo agency="FReSH">
                    FRESH-PEF73421                </IDNo>
    </titlStmt>
    <rspStmt>
      <AuthEnty>
                    Laurence SLAMA                                                                                                                            </AuthEnty>
      <AuthEnty affiliation="ASSISTANCE PUBLIQUE HOPITAUX DE PARIS (AP-HP)">
        <ExtLink title="ROR" URI="https://ror.org/00pg5jh14" role="organisation id"/>
        <ExtLink title="SIREN" URI="267500452" role="organisation id"/>
      </AuthEnty>
      <AuthEnty>
                    Hubert BLAIN                                                                                                                            </AuthEnty>
      <AuthEnty affiliation="CENTRE HOSPITALIER UNIVERSITAIRE DE MONTPELLIER (CHU)">
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        <ExtLink title="SIREN" URI="263400160" role="organisation id"/>
      </AuthEnty>
      <AuthEnty>
                    Clotilde ALLAVENA                                                                                                                            </AuthEnty>
      <AuthEnty affiliation="CENTRE HOSPITALIER UNIVERSITAIRE DE NANTES">
        <ExtLink title="ROR" URI="https://ror.org/05c1qsg97" role="organisation id"/>
        <ExtLink title="SIREN" URI="264400136" role="organisation id"/>
      </AuthEnty>
      <AuthEnty>
                    Laurence MEYER                                                                                                                            </AuthEnty>
      <AuthEnty affiliation="INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)">
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        <ExtLink title="SIREN" URI="180036048" role="organisation id"/>
      </AuthEnty>
      <AuthEnty>
                    Mariem RAHO-MOUSSA                                                                                                                            </AuthEnty>
      <AuthEnty affiliation="INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)">
        <ExtLink title="ROR" URI="https://ror.org/02vjkv261" role="organisation id"/>
        <ExtLink title="SIREN" URI="180036048" role="organisation id"/>
      </AuthEnty>
      <othId affiliation="Collaborations with other research teams on similar themes (ANRS CO4, ANRS CO3, cohorts in the general population)" type="collaboration">
                                    </othId>
    </rspStmt>
    <prodStmt>
      <producer role="sponsor">
                                            AGENCE NATIONALE DE RECHERCHES SUR LE SIDA ET LES HEPATITES VIRALES (ANRS MIE)                    
                                    </producer>
      <prodPlac>
                Epidemiology France Portal (PEF)            </prodPlac>
      <fundAg>
                                            AGENCE NATIONALE DE RECHERCHES SUR LE SIDA ET LES HEPATITES VIRALES (ANRS MIE)                    
                                    </fundAg>
      <fundAg>
                                            GILEAD SCIENCES                    
                                    </fundAg>
      <fundAg>
                                            MSD FRANCE                    
                                    </fundAg>
      <fundAg>
                                            VIIV HEALTHCARE SAS                    
                                    </fundAg>
    </prodStmt>
    <distStmt>
      <distrbtr abbr="null">
                    null</distrbtr>
      <contact affiliation="ASSISTANCE PUBLIQUE HOPITAUX DE PARIS (AP-HP)" email="laurence.meyer@aphp.fr">
                    Laurence;SLAMA
                                            <ExtLink title="ROR" URI="https://ror.org/00pg5jh14" role="organisation id"/>
                                            <ExtLink title="SIREN" URI="267500452" role="organisation id"/>
                                    </contact>
      <contact affiliation="CENTRE HOSPITALIER UNIVERSITAIRE DE MONTPELLIER (CHU)" email="h-blain@chu-montpellier.fr">
                    Hubert;BLAIN
                                            <ExtLink title="ROR" URI="https://ror.org/00mthsf17" role="organisation id"/>
                                            <ExtLink title="SIREN" URI="263400160" role="organisation id"/>
                                    </contact>
      <contact affiliation="CENTRE HOSPITALIER UNIVERSITAIRE DE MONTPELLIER (CHU)" email="a-makinson@chu-montpellier.fr">
                    Alain;MAKINSON
                                            <ExtLink title="ROR" URI="https://ror.org/00mthsf17" role="organisation id"/>
                                            <ExtLink title="SIREN" URI="263400160" role="organisation id"/>
                                    </contact>
      <contact affiliation="CENTRE HOSPITALIER UNIVERSITAIRE DE NANTES" email="clotilde.allavena@chu-nantes.fr">
                    Clotilde;ALLAVENA
                                            <ExtLink title="ROR" URI="https://ror.org/05c1qsg97" role="organisation id"/>
                                            <ExtLink title="SIREN" URI="264400136" role="organisation id"/>
                                    </contact>
      <contact affiliation="INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)" email="laurence.meyer@inserm.fr">
                    Laurence;MEYER
                                            <ExtLink title="ROR" URI="https://ror.org/02vjkv261" role="organisation id"/>
                                            <ExtLink title="SIREN" URI="180036048" role="organisation id"/>
                                    </contact>
      <contact affiliation="INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)" email="mariem.raho@clin4all.com">
                    Mariem;RAHO-MOUSSA
                                            <ExtLink title="ROR" URI="https://ror.org/02vjkv261" role="organisation id"/>
                                            <ExtLink title="SIREN" URI="180036048" role="organisation id"/>
                                    </contact>
      <depDate date="2026-06-17"/>
      <distDate date="2026-06-17"/>
    </distStmt>
    <biblCit format="">
            </biblCit>
    <holdings URI="null"/>
    <notes> </notes>
  </citation>
  <stdyInfo>
    <studyBudget/>
    <subject>
      <keyword vocab="" vocabURI="">
                    HIV infection</keyword>
      <keyword vocab="" vocabURI="">
                    frailty</keyword>
      <keyword vocab="" vocabURI="">
                    geriatrics</keyword>
      <topcClas vocab="health theme">
                        Geriatrics                                                        <ExtLink title="ESV" URI="http://data.europa.eu/8mn/euroscivoc/d37e4d8c-a978-40c7-ba4f-eee841851073"/>
                                                            <ExtLink title="MeSH" URI="http://id.nlm.nih.gov/mesh/D005853"/>
                                                </topcClas>
      <topcClas vocab="health theme">
                        Infectious disease medicine                                                        <ExtLink title="ESV" URI="http://data.europa.eu/8mn/euroscivoc/fa2ceeab-3b2f-45e9-9243-e5a8005b98de"/>
                                                            <ExtLink title="MeSH" URI="http://id.nlm.nih.gov/mesh/D055552"/>
                                                </topcClas>
      <topcClas vocab="health theme">
                        Internal medicine                                                        <ExtLink title="ESV" URI="http://data.europa.eu/8mn/euroscivoc/0d45044a-74d5-4bd7-b920-b92af3388576"/>
                                                            <ExtLink title="ESV" URI="http://data.europa.eu/8mn/euroscivoc/f0844378-9f30-4873-b19b-5bff8c184a36"/>
                                                            <ExtLink title="MeSH" URI="http://id.nlm.nih.gov/mesh/D007388"/>
                                                </topcClas>
      <topcClas vocab="cim-11">
                        Human immunodeficiency virus disease without mention of tuberculosis or malaria                                            </topcClas>
      <topcClas vocab="health determinant">
                        Behavioral determinants: Addiction                    </topcClas>
      <topcClas vocab="health determinant">
                        Socio-demographic and economic determinants                    </topcClas>
      <topcClas vocab="health determinant">
                        Healthcare system determinants: Use of care                    </topcClas>
      <topcClas vocab="health determinant">
                        Behavioral determinants                    </topcClas>
      <topcClas vocab="health determinant">
                        Healthcare system determinants                    </topcClas>
    </subject>
    <abstract contentType="purpose">To evaluate the prevalence of frailty according to Fried's criteria in people living with HIV aged 70 and over Secondary objectives: To study and describe frailty in PLHIV aged 70 and over according to different indexes: Fried, Cumulative Deficit Index, HAS score, VACS index Study the association between frailty and various parameters specific to HIV infection and other non-specific parameters Identify factors associated with frailty at M0 and with progression or regression of frailty during 12 months of follow-up Study the occurrence of adverse health events during the 12 months of follow-up (falls, emergency room visits, hospitalisations, institutionalisation, loss of an iADL point, death) Evaluate the prevalence of sarcopenia and osteoporosis Describe the population (socio-demographic characteristics, socio-economic level, HIV infection and treatment history, comorbidities, polymedication, mental health, quality of life, etc.) Study inflammatory and immunosenescence markers at M0</abstract>
    <abstract contentType="abstract">null</abstract>
    <sumDscr>
      <collDate event="start" date="2019-01-01"/>
      <collDate event="end" date="2021-01-01"/>
      <nation abbr="fr">
                    France
                                            <concept vocab="ISO" vocabURI="fr"/>
                                    </nation>
      <geogUnit/>
      <anlyUnit>
                Individuals            </anlyUnit>
      <universe level="type" clusion="I">Patients population                    </universe>
      <universe level="sex" clusion="I">Male                                                            <concept vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D008297"/>
                                                    </universe>
      <universe level="sex" clusion="I">Female                                                            <concept vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D005260"/>
                                                    </universe>
      <universe level="sex" clusion="I">Other                                                    </universe>
      <universe level="age" clusion="I">Aged (65 to 79 years)                                                            <concept vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D000368"/>
                                                    </universe>
      <universe level="age" clusion="I">Aged, 80 and over (80 years and more)                                                            <concept vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D000369"/>
                                                    </universe>
      <dataKind>Clinical data</dataKind>
      <dataKind>Participant-reported health data</dataKind>
      <dataKind>Biological data</dataKind>
      <dataKind>Paraclinical data (non-biological) : Imaging</dataKind>
    </sumDscr>
    <qualityStatement>
      <standardsCompliance>
        <standard>
          <standardName>ATC for drugs</standardName>
          <standardName>ICD10 for cause of death</standardName>
        </standard>
      </standardsCompliance>
      <otherQualityStatement>Risk-based monitoring (on-site and remote)</otherQualityStatement>
      <otherQualityStatement>planned data management procedures</otherQualityStatement>
    </qualityStatement>
  </stdyInfo>
  <method>
    <dataColl>
      <sampProc>Other                                                            <concept vocab="CESSDA" vocabURI="Other"/>
                                                    </sampProc>
      <sampleFrame>
        <frameUnit>
          <unitType>Through organizations (health services or institutions</unitType>
        </frameUnit>
        <frameUnit>
          <unitType>schools</unitType>
        </frameUnit>
        <frameUnit>
          <unitType>businesses</unitType>
        </frameUnit>
        <frameUnit>
          <unitType>etc.)</unitType>
        </frameUnit>
      </sampleFrame>
      <collMode>Other                                                            <concept vocab="CESSDA" vocabURI="Other"/>
                                                    </collMode>
    </dataColl>
    <notes>Observational Study</notes>
    <notes subject="research type">
                        Observational Study                    </notes>
    <anlyInfo>
      <respRate>512</respRate>
    </anlyInfo>
    <stdyClas>Unknown</stdyClas>
  </method>
  <dataAccs>
    <setAvail>
      <avlStatus>
                            To be defined                                                    </avlStatus>
    </setAvail>
  </dataAccs>
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<dataDscr>
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