{"study_desc":{"title_statement":{"idno":"FRESH-PEF73141-en","IDno":{"metadata_no":[{"agency":"PEF","code":"73141"},{"agency":"FReSH","code":"FRESH-PEF73141"}]},"title":"Case-Control Study of Children with Hypospadias","alternate_title":""},"study_authorization":{"agency":[{"name":"CPP"},{"name":"ANSM"}]},"authoring_entity":[{"name":"Nicolas;KALFA","firstname":"Nicolas","lastname":"KALFA","type":"investigator","extlink":[{"title":"ROR","uri":"https:\/\/ror.org\/00mthsf17","role":"organisation id"},{"title":"SIREN","uri":"263400160","role":"organisation id"},{"uri":"075645114","role":"pi id","title":"IdRef"}],"email":"nicolaskalfa@gmail.com","affiliationName":"CENTRE HOSPITALIER UNIVERSITAIRE DE MONTPELLIER (CHU)","PILabo":"Montpellier University Hospital","isContact":true}],"oth_id":[{"name":""}],"production_statement":{"prod_place":"Epidemiology France Portal (PEF)","producers":[{"name":"CENTRE HOSPITALIER UNIVERSITAIRE DE MONTPELLIER (CHU)","extlink":[{"title":"ROR","uri":"https:\/\/ror.org\/00mthsf17","role":"sponsor id"},{"title":"SIREN","uri":"263400160","role":"sponsor id"}],"role":"sponsor"}],"funding_agencies":[{"name":"CENTRE HOSPITALIER UNIVERSITAIRE DE MONTPELLIER (CHU)","extlink":[{"title":"ROR","uri":"https:\/\/ror.org\/00mthsf17"},{"title":"SIREN","uri":"263400160"}]}]},"distribution_statement":{"contact":[{"name":"Nicolas;KALFA","lastname":"KALFA","firstname":"Nicolas","type":"contact","email":"nicolaskalfa@gmail.com","affiliationName":"CENTRE HOSPITALIER UNIVERSITAIRE DE MONTPELLIER (CHU)","contactPointLabo":"","extlink":[{"uri":"https:\/\/ror.org\/00mthsf17","role":"organisation id","title":"ROR"},{"uri":"263400160","role":"organisation id","title":"SIREN"}]}]},"study_info":{"keywords":[{"keyword":"sexual determination disorder"},{"keyword":"endocrine disrupting chemicals"},{"keyword":"birth defect"},{"keyword":"environment"},{"keyword":"profession"},{"keyword":"pesticides"},{"keyword":"hypospadias"}],"topics":[{"topic":"Glaucoma","vocab":"cim-11","extLink":[{"uri":"http:\/\/id.who.int\/icd\/entity\/499924848","title":"CIM-11"}]},{"topic":"Biological determinants: Genetic predisposition","vocab":"health determinant"},{"topic":"Environmental determinants","vocab":"health determinant"},{"topic":"Biological determinants","vocab":"health determinant"}],"purpose":"The objective of the study is to identify the impact of occupational and environmental exposure to endocrine-disrupting chemicals on non-genetic, isolated hypospadias.","abstract":"","coll_dates":[{"start":"2009-01-01","end":"2014-01-01"}],"nation":[{"name":"France","abbreviation":"fr","extLink":{"vocab":"ISO","vocabURI":"fr"}}],"geog_coverage":"['Occitanie']","analysis_unit":"Individuals","universe":"{\"level_sex_clusion_I\":[{\"value\":\"Male\",\"concept\":{\"vocab\":\"MeSH\",\"vocabURI\":\"D008297\"}}],\"level_age_clusion_I\":[{\"value\":\"Infant, Newborn (birth to 28 days)\",\"concept\":{\"vocab\":\"MeSH\",\"vocabURI\":\"D007231\"}},{\"value\":\"Infant (28 days to 2 years)\",\"concept\":{\"vocab\":\"MeSH\",\"vocabURI\":\"D007223\"}},{\"value\":\"Child, Preschool (2 to 5 years)\",\"concept\":{\"vocab\":\"MeSH\",\"vocabURI\":\"D002675\"}},{\"value\":\"Child (6 to 12 years)\",\"concept\":{\"vocab\":\"MeSH\",\"vocabURI\":\"D002648\"}}],\"level_type_clusion_I\":\"Patients population\",\"level_type_clusion_other\":\"\",\"clusion_I\":\"Children with hypospadias (from birth to 12 years old);  Controls: Normal children (no congenital, urological, genital or renal malformation; no inguinal hernia or endocrine diseases). 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