Cohort of French Families with Identified MMR Gene Mutation: Assessment of Cancer Risk FRESH-PEF73086-en Christine LASSET Cohort of French Families with Identified MMR Gene Mutation: Assessment of Cancer Risk ERISCAM FRESH-PEF73086-en 73086 FRESH-PEF73086 Valérie BONADONA Christine LASSET Catherine BONAITI-PELLIE Sylviane OLSCHWANG CENTRE LEON BERARD Epidemiology France Portal (PEF) FONDATION DE FRANCE null Valérie;BONADONA Christine;LASSET Catherine;BONAITI-PELLIE Sylviane;OLSCHWANG Lynch syndrome gynaecology MMR genes cumulative risk MLH1 MSH2 MSH6 colorectal cancer genetic mutation Oncology Gynaecology and obstetrics Gastroenterology Hepatology Malignant neoplasms of colon Biological determinants: Genetic predisposition Biological determinants The aim is to reliably and accurately determine the risks of different tumours in subjects with MMR gene mutations. null France Individuals Patients population Male Female Young Adult (19 to 24 years) Adult (25 to 44 years) Middle Aged (45 to 64 years) Aged (65 to 79 years) Aged, 80 and over (80 years and more) French families with an identified MMR gene mutation recruited throughout 40 cancer genetic consultation centres participating in the study; all members of the Cancer and Genetics Network. Clinical data Participant-reported health data Other Medical-administrative database (patients health insurance/mutual insurance) Disease and death registry [1000-10000[ individuals Converting or copying information into a structured record Interview with the participant (including clinical) Observational Study Observational Study Cohort study 537 families (248: MSH1 mutation, 256 MSH2 mutation, 33 MSH6 mutation). 2,622 patients Unknown Restricted access Contact the principal investigator Access on specific project only