{"study_desc":{"title_statement":{"idno":"FRESH-PEF6115-en","IDno":{"metadata_no":[{"agency":"PEF","code":"6115"},{"agency":"FReSH","code":"FRESH-PEF6115"}]},"title":"Inflammatory pulmonary diseases in coal miners","alternate_title":""},"study_authorization":{"agency":[{"name":"CNIL"}]},"authoring_entity":[{"name":"Rachel;NADIF","firstname":"Rachel","lastname":"NADIF","type":"investigator","extlink":[{"title":"ROR","uri":"https:\/\/ror.org\/02vjkv261","role":"organisation id"},{"title":"SIREN","uri":"180036048","role":"organisation id"},{"uri":"0000-0003-4938-9339","role":"pi id","title":"ORCID"},{"uri":"19287456X","role":"pi id","title":"IdRef"}],"email":"rachel.nadif@inserm.fr","affiliationName":"INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)","PILabo":"Institut National de Sant\u00e9 et Recherche \/ Recherche en \u00c9pid\u00e9miologie et Biostatistique","isContact":true}],"oth_id":[{"name":""}],"production_statement":{"prod_place":"Epidemiology France Portal (PEF)","producers":[{"name":"INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)","extlink":[{"title":"ROR","uri":"https:\/\/ror.org\/02vjkv261","role":"sponsor id"},{"title":"SIREN","uri":"180036048","role":"sponsor id"}],"role":"sponsor"}],"funding_agencies":[{"name":"NIH","extlink":[{"title":"SIREN","uri":"839398096"}]},{"name":""}]},"distribution_statement":{"contact":[{"name":"Rachel;NADIF","lastname":"NADIF","firstname":"Rachel","type":"contact","email":"rachel.nadif@inserm.fr","affiliationName":"INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)","contactPointLabo":"","extlink":[{"uri":"https:\/\/ror.org\/02vjkv261","role":"organisation id","title":"ROR"},{"uri":"180036048","role":"organisation id","title":"SIREN"}]}]},"study_info":{"keywords":[{"keyword":"Coal mine - dust - genetic polymorphisms - chest radiography"}],"topics":[{"topic":"Public, environmental and occupational health","vocab":"health theme","extLink":[{"title":"ESV","uri":"http:\/\/data.europa.eu\/8mn\/euroscivoc\/b533acc2-aff1-4c65-80ca-5d5bee865ba9"},{"title":"MeSH","uri":"D004778"}]},{"topic":"Pulmonary medicine","vocab":"health theme","extLink":[{"title":"ESV","uri":"http:\/\/data.europa.eu\/8mn\/euroscivoc\/f6e18c52-6087-4662-904c-5c4b8174e40e"},{"title":"MeSH","uri":"D015272"}]},{"topic":"Biological determinants: Genetic predisposition","vocab":"health determinant"},{"topic":"Biological determinants","vocab":"health determinant"}],"purpose":"The study of Lorraine Miners was set up in 1990 with 2 main objectives. - To estimate the predictive value of chest tomodensitometry and of sensitive functional tests in the development of peumoconioses. - To test specific hypotheses about the physiology of emphysema and fibrosis using biological markers: proteases\/antiproteases, oxidative\/antioxidative and degradation\/repair balances. 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