<?xml version="1.0" encoding="UTF-8"?>
<codeBook version="2.5" ID="FRESH-PEF60195-en" xml-lang="en" xmlns="ddi:codebook:2_5" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="ddi:codebook:2_5 https://ddialliance.org/Specification/DDI-Codebook/2.5/XMLSchema/codebook.xsd">
<docDscr>
  <citation>
    <titlStmt>
      <titl>Asthma newborn cohort/Exhaled Nitric Oxide as a Predictive Marker for Asthma?</titl>
      <IDNo>FRESH-PEF60195-en</IDNo>
    </titlStmt>
    <prodStmt>
      <producer abbr="" affiliation="SORBONNE UNIVERSITE" role="">Jocelyne JUST</producer>
    </prodStmt>
    <verStmt>
      <version></version>
    </verStmt>
  </citation>
</docDscr>
<stdyDscr>
  <citation>
    <titlStmt>
      <titl>
                Asthma newborn cohort/Exhaled Nitric Oxide as a Predictive Marker for Asthma?            </titl>
      <altTitl>
                    NOA                </altTitl>
      <IDNo agency="FReSH-lang">
                FRESH-PEF60195-en            </IDNo>
      <IDNo agency="PEF">
                    60195                </IDNo>
      <IDNo agency="FReSH">
                    FRESH-PEF60195                </IDNo>
    </titlStmt>
    <rspStmt>
      <AuthEnty>
                    Jocelyne JUST                                                                                                                            </AuthEnty>
      <AuthEnty affiliation="SORBONNE UNIVERSITE">
        <ExtLink title="ROR" URI="https://ror.org/02en5vm52" role="organisation id"/>
        <ExtLink title="SIREN" URI="130023385" role="organisation id"/>
      </AuthEnty>
      <AuthEnty>
                    Isabelle MOMAS                                                                                                                            </AuthEnty>
      <AuthEnty affiliation="UNIVERSITE PARIS CITE">
        <ExtLink title="ROR" URI="https://ror.org/05f82e368" role="organisation id"/>
        <ExtLink title="SIREN" URI="130025737" role="organisation id"/>
      </AuthEnty>
      <othId affiliation="" type="">
                                    </othId>
    </rspStmt>
    <prodStmt>
      <producer role="sponsor">
                                            ASSISTANCE PUBLIQUE HOPITAUX DE PARIS (AP-HP)                    
                                    </producer>
      <prodPlac>
                Epidemiology France Portal (PEF)            </prodPlac>
      <fundAg>
                                            SOCIETE DE PNEUMOLOGIE DE LANGUE FRANCAISE                    
                                    </fundAg>
    </prodStmt>
    <distStmt>
      <distrbtr abbr="null">
                    null</distrbtr>
      <contact affiliation="SORBONNE UNIVERSITE" email="jocelyne.just@ahparis.org">
                    Jocelyne;JUST
                                            <ExtLink title="ROR" URI="https://ror.org/02en5vm52" role="organisation id"/>
                                            <ExtLink title="SIREN" URI="130023385" role="organisation id"/>
                                    </contact>
      <contact affiliation="UNIVERSITE PARIS CITE" email="isabelle.momas@u-paris.fr">
                    Isabelle;MOMAS
                                            <ExtLink title="ROR" URI="https://ror.org/05f82e368" role="organisation id"/>
                                            <ExtLink title="SIREN" URI="130025737" role="organisation id"/>
                                    </contact>
      <depDate date="2026-06-16"/>
      <distDate date="2026-06-16"/>
    </distStmt>
    <biblCit format="">
            </biblCit>
    <holdings URI="null"/>
    <notes> </notes>
  </citation>
  <stdyInfo>
    <studyBudget/>
    <subject>
      <keyword vocab="" vocabURI="">
                    prognosis</keyword>
      <keyword vocab="" vocabURI="">
                    paediatrics</keyword>
      <keyword vocab="" vocabURI="">
                    Morbidity</keyword>
      <keyword vocab="" vocabURI="">
                    mortality</keyword>
      <keyword vocab="" vocabURI="">
                    genetic factors</keyword>
      <keyword vocab="" vocabURI="">
                    diagnosis</keyword>
      <topcClas vocab="health theme">
                        Allergology                                                        <ExtLink title="ESV" URI="http://data.europa.eu/8mn/euroscivoc/af65e2bf-afc5-45e8-a0fc-364dfb48f0a4"/>
                                                            <ExtLink title="MeSH" URI="http://id.nlm.nih.gov/mesh/D000486"/>
                                                </topcClas>
      <topcClas vocab="health theme">
                        Pulmonary medicine                                                        <ExtLink title="ESV" URI="http://data.europa.eu/8mn/euroscivoc/f6e18c52-6087-4662-904c-5c4b8174e40e"/>
                                                            <ExtLink title="MeSH" URI="http://id.nlm.nih.gov/mesh/D015272"/>
                                                </topcClas>
      <topcClas vocab="health theme">
                        Paediatrics                                                        <ExtLink title="ESV" URI="http://data.europa.eu/8mn/euroscivoc/bf8aaaac-ddee-41cd-bb8a-c5a63de3fcbd"/>
                                                            <ExtLink title="MeSH" URI="http://id.nlm.nih.gov/mesh/D010372"/>
                                                </topcClas>
      <topcClas vocab="cim-11">
                        Asthma                                            </topcClas>
    </subject>
    <abstract contentType="purpose">To show that an increase in eNO, a biomarker of airway inflammation, is a risk factor expected from passage of recurrent wheezing in infancy towards childhood asthma at pre-school age (age 4 to 7 years old). Secondary objectives: - To assemble an international cohort of patients selected from homogeneous criteria established by a panel of experts. - To allow a homogeneous collection of retrospective and prospective data on childhood BD in real-time thanks to the creation of an on-line database. - To support genetic studies and conduct a parallel collection of DNA.</abstract>
    <abstract contentType="abstract">null</abstract>
    <sumDscr>
      <collDate event="start" date="2010-01-01"/>
      <collDate event="end" date="2014-01-01"/>
      <nation abbr="fr">
                    France
                                            <concept vocab="ISO" vocabURI="fr"/>
                                    </nation>
      <geogCover>Ile-de-France</geogCover>
      <geogUnit/>
      <anlyUnit>
                Individuals            </anlyUnit>
      <universe level="type" clusion="I">Patients population                    </universe>
      <universe level="sex" clusion="I">Male                                                            <concept vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D008297"/>
                                                    </universe>
      <universe level="sex" clusion="I">Female                                                            <concept vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D005260"/>
                                                    </universe>
      <universe level="age" clusion="I">Infant, Newborn (birth to 28 days)                                                            <concept vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D007231"/>
                                                    </universe>
      <universe clusion="I">less than 30 monhts - asthma or Allergic Rhinitis                    </universe>
      <dataKind>Participant-reported health data</dataKind>
      <dataKind>Biological data</dataKind>
    </sumDscr>
  </stdyInfo>
  <studyDevelopment>
    <developmentActivity type="primary evaluation">
      <description>Health event/morbidity
Health event/mortality</description>
    </developmentActivity>
  </studyDevelopment>
  <method>
    <dataColl>
      <sampProc>Other                                                            <concept vocab="CESSDA" vocabURI="Other"/>
                                                    </sampProc>
      <sampleFrame>
        <frameUnit>
          <unitType>Through organizations (health services or institutions</unitType>
        </frameUnit>
        <frameUnit>
          <unitType>schools</unitType>
        </frameUnit>
        <frameUnit>
          <unitType>businesses</unitType>
        </frameUnit>
        <frameUnit>
          <unitType>etc.)</unitType>
        </frameUnit>
      </sampleFrame>
      <targetSampleSize>
        <sampleSizeFormula>&lt; 500 individuals                        </sampleSizeFormula>
      </targetSampleSize>
      <collMode>Interview with the participant (including clinical)                                                            <concept vocab="CESSDA" vocabURI="Interview"/>
                                                    </collMode>
    </dataColl>
    <notes>Observational Study</notes>
    <notes subject="research type">
                        Observational Study                    </notes>
    <notes subject="observational study method">
                        Cohort study                    </notes>
    <anlyInfo>
      <respRate>315</respRate>
    </anlyInfo>
    <stdyClas>Unknown</stdyClas>
  </method>
  <dataAccs>
    <setAvail>
      <avlStatus>
                            Metadata-only access                                                    </avlStatus>
    </setAvail>
  </dataAccs>
  <othrStdyMat>
    <relMat>Access on specific project only</relMat>
  </othrStdyMat>
</stdyDscr>
<dataDscr>
</dataDscr></codeBook>
