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<docDscr>
  <citation>
    <titlStmt>
      <titl>Evaluation of the risk of radiation-induced cancer or leukaemia in a cohort of children who have had one or several CT scans during childhood.</titl>
      <IDNo>FRESH-PEF60187-en</IDNo>
    </titlStmt>
    <prodStmt>
      <producer abbr="" affiliation="AUTORITE DE SURETE NUCLEAIRE ET DE RADIOPROTECTION (ASNR)" role="">Marie-odile BERNIER</producer>
    </prodStmt>
    <verStmt>
      <version></version>
    </verStmt>
  </citation>
</docDscr>
<stdyDscr>
  <citation>
    <titlStmt>
      <titl>
                Evaluation of the risk of radiation-induced cancer or leukaemia in a cohort of children who have had one or several CT scans during childhood.            </titl>
      <altTitl>
                    ENFANT SCANNER (CHILD CT SCANS)                </altTitl>
      <IDNo agency="FReSH-lang">
                FRESH-PEF60187-en            </IDNo>
      <IDNo agency="PEF">
                    60187                </IDNo>
      <IDNo agency="FReSH">
                    FRESH-PEF60187                </IDNo>
    </titlStmt>
    <rspStmt>
      <AuthEnty>
                    Marie-Odile BERNIER                                                                                                                            </AuthEnty>
      <AuthEnty affiliation="AUTORITE DE SURETE NUCLEAIRE ET DE RADIOPROTECTION (ASNR)">
        <ExtLink title="ROR" URI="https://ror.org/04dbtaf18" role="organisation id"/>
        <ExtLink title="SIREN" URI="130001803" role="organisation id"/>
      </AuthEnty>
      <AuthEnty>
                    Sophie JACOB                                                                                                                            </AuthEnty>
      <AuthEnty affiliation="AUTORITE DE SURETE NUCLEAIRE ET DE RADIOPROTECTION (ASNR)">
        <ExtLink title="ROR" URI="https://ror.org/04dbtaf18" role="organisation id"/>
        <ExtLink title="SIREN" URI="130001803" role="organisation id"/>
      </AuthEnty>
      <AuthEnty>
                    Dominique LAURIER                                                                                                                            </AuthEnty>
      <AuthEnty affiliation="AUTORITE DE SURETE NUCLEAIRE ET DE RADIOPROTECTION (ASNR)">
        <ExtLink title="ROR" URI="https://ror.org/04dbtaf18" role="organisation id"/>
        <ExtLink title="SIREN" URI="130001803" role="organisation id"/>
      </AuthEnty>
      <othId affiliation="" type="">
                                    </othId>
      <othId affiliation="" type="">
                                    </othId>
    </rspStmt>
    <prodStmt>
      <producer role="sponsor">
                                            AUTORITE DE SURETE NUCLEAIRE ET DE RADIOPROTECTION (ASNR)                    
                                    </producer>
      <prodPlac>
                Epidemiology France Portal (PEF)            </prodPlac>
      <fundAg>
                                            EUROPEAN COMMISSION RESEARCH                    
                                    </fundAg>
      <fundAg>
                                            AUTORITE DE SURETE NUCLEAIRE ET DE RADIOPROTECTION (ASNR)                    
                                    </fundAg>
      <fundAg>
                                            INSTITUT NATIONAL DU CANCER (INCA)                    
                                    </fundAg>
      <fundAg>
                                            LIGUE NATIONALE CONTRE LE CANCER (LNCC)                    
                                    </fundAg>
    </prodStmt>
    <distStmt>
      <distrbtr abbr="null">
                    null</distrbtr>
      <contact affiliation="AUTORITE DE SURETE NUCLEAIRE ET DE RADIOPROTECTION (ASNR)" email="marie-odile.bernier@irsn.fr">
                    Marie-Odile;BERNIER
                                            <ExtLink title="ROR" URI="https://ror.org/04dbtaf18" role="organisation id"/>
                                            <ExtLink title="SIREN" URI="130001803" role="organisation id"/>
                                    </contact>
      <contact affiliation="AUTORITE DE SURETE NUCLEAIRE ET DE RADIOPROTECTION (ASNR)" email="sophie.jacob@irsn.fr">
                    Sophie;JACOB
                                            <ExtLink title="ROR" URI="https://ror.org/04dbtaf18" role="organisation id"/>
                                            <ExtLink title="SIREN" URI="130001803" role="organisation id"/>
                                    </contact>
      <contact affiliation="AUTORITE DE SURETE NUCLEAIRE ET DE RADIOPROTECTION (ASNR)" email="dominique.laurier@irsn.fr">
                    Dominique;LAURIER
                                            <ExtLink title="ROR" URI="https://ror.org/04dbtaf18" role="organisation id"/>
                                            <ExtLink title="SIREN" URI="130001803" role="organisation id"/>
                                    </contact>
      <depDate date="2026-06-17"/>
      <distDate date="2026-06-17"/>
    </distStmt>
    <biblCit format="">
            </biblCit>
    <holdings URI="null"/>
    <notes> </notes>
  </citation>
  <stdyInfo>
    <studyBudget/>
    <subject>
      <keyword vocab="" vocabURI="">
                    leukaemia</keyword>
      <keyword vocab="" vocabURI="">
                    health</keyword>
      <keyword vocab="" vocabURI="">
                    environment</keyword>
      <topcClas vocab="health theme">
                        Oncology                                                        <ExtLink title="ESV" URI="http://data.europa.eu/8mn/euroscivoc/5784b7f1-c7ce-49d9-9f38-aebcda0ff41d"/>
                                                            <ExtLink title="MeSH" URI="http://id.nlm.nih.gov/mesh/D008495"/>
                                                </topcClas>
      <topcClas vocab="health theme">
                        Paediatrics                                                        <ExtLink title="ESV" URI="http://data.europa.eu/8mn/euroscivoc/bf8aaaac-ddee-41cd-bb8a-c5a63de3fcbd"/>
                                                            <ExtLink title="MeSH" URI="http://id.nlm.nih.gov/mesh/D010372"/>
                                                </topcClas>
      <topcClas vocab="health determinant">
                        Healthcare system determinants: Use of care                    </topcClas>
      <topcClas vocab="health determinant">
                        Healthcare system determinants                    </topcClas>
    </subject>
    <abstract contentType="purpose">General objective: the goal of this study is to evaluate the risk of radiation-induced cancer or leukaemia associated with use of CT during early childhood (first scan carried out between the ages of 0 and 10 years), and to quantify the relationship between exposure to ionising radiation and the onset of the pathologies being studied. Secondary objective: to study any possible modifying factors (age at exposure, gender etc.) in this dose-response relationship.</abstract>
    <abstract contentType="abstract">null</abstract>
    <sumDscr>
      <collDate event="start" date="2000-01-01"/>
      <nation abbr="fr">
                    France
                                            <concept vocab="ISO" vocabURI="fr"/>
                                    </nation>
      <geogUnit/>
      <anlyUnit>
                Individuals            </anlyUnit>
      <universe level="type" clusion="I">General population                    </universe>
      <universe level="sex" clusion="I">Male                                                            <concept vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D008297"/>
                                                    </universe>
      <universe level="sex" clusion="I">Female                                                            <concept vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D005260"/>
                                                    </universe>
      <universe level="age" clusion="I">Infant, Newborn (birth to 28 days)                                                            <concept vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D007231"/>
                                                    </universe>
      <universe level="age" clusion="I">Infant (28 days to 2 years)                                                            <concept vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D007223"/>
                                                    </universe>
      <universe level="age" clusion="I">Child, Preschool (2 to 5 years)                                                            <concept vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D002675"/>
                                                    </universe>
      <universe level="age" clusion="I">Child (6 to 12 years)                                                            <concept vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D002648"/>
                                                    </universe>
      <universe clusion="I">Inclusion of children exposed to at least one CT scan for a nonmalignant pathology: - under 5 years for the 2000-2006 period - under 10 years for the 2007-2013 period.                    </universe>
      <dataKind>Clinical data</dataKind>
      <dataKind>Socio-demographic data</dataKind>
      <dataKind>Paraclinical data (non-biological) : Imaging</dataKind>
    </sumDscr>
  </stdyInfo>
  <studyDevelopment>
    <developmentActivity type="primary evaluation">
      <description>Health event/morbidity
Health event/mortality
Health care consumption and services</description>
    </developmentActivity>
  </studyDevelopment>
  <method>
    <dataColl>
      <sampProc>Other                                                            <concept vocab="CESSDA" vocabURI="Other"/>
                                                    </sampProc>
      <sampleFrame>
        <frameUnit>
          <unitType>Through organizations (health services or institutions</unitType>
        </frameUnit>
        <frameUnit>
          <unitType>schools</unitType>
        </frameUnit>
        <frameUnit>
          <unitType>businesses</unitType>
        </frameUnit>
        <frameUnit>
          <unitType>etc.) Medical-administrative database (patients</unitType>
        </frameUnit>
        <frameUnit>
          <unitType>health insurance/mutual insurance)</unitType>
        </frameUnit>
      </sampleFrame>
      <targetSampleSize>
        <sampleSizeFormula>&gt;= 20000 individuals                        </sampleSizeFormula>
      </targetSampleSize>
      <collMode>Other                                                            <concept vocab="CESSDA" vocabURI="Other"/>
                                                    </collMode>
    </dataColl>
    <notes>Observational Study</notes>
    <notes subject="research type">
                        Observational Study                    </notes>
    <notes subject="observational study method">
                        Cohort study                    </notes>
    <anlyInfo>
      <respRate>130 000</respRate>
    </anlyInfo>
    <stdyClas>Unknown</stdyClas>
  </method>
  <dataAccs>
    <setAvail>
      <avlStatus>
                            Metadata-only access                                                    </avlStatus>
    </setAvail>
  </dataAccs>
  <othrStdyMat>
    <relMat>Access on specific project only</relMat>
  </othrStdyMat>
</stdyDscr>
<dataDscr>
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