Adult Health Childhood GH FRESH-PEF60178-en Jean-Claude CAREL Adult Health Childhood GH SAGHE FRESH-PEF60178-en 60178 FRESH-PEF60178 Jean-Claude CAREL ASSISTANCE PUBLIQUE HOPITAUX DE PARIS (AP-HP) Epidemiology France Portal (PEF) EUROPEAN COMMISSION RESEARCH AGENCE NATIONALE DE SECURITE DU MEDICAMENT ET DES PRODUITS DE SANTE (ANSM) INSTITUT NATIONAL DU CANCER (INCA) MINISTERE DU TRAVAIL, DE LA SANTE, DES SOLIDARITES ET DES FAMILLES null Jean-Claude;CAREL Socio-professional insertion Endocrinology Paediatrics Socio-demographic and economic determinants: Employment Healthcare system determinants: Use of care Socio-demographic and economic determinants Healthcare system determinants To resolve outstanding issues concerning growth hormone deficiency, Turner's syndrome and patients treated with growth hormone. Secondary objectives: - To explain the frequency and severity of hormonal, metabolic, skeletal, and cardiovascular events during life as well as their determinants. - To identify patient subgroups according to the severity and their phenotypic and/or genetic characteristics in relation to both French molecular genetics laboratories, hospitals and INSERM for developmental pituitary gland abnormalities. - To better understand patient outcome in terms of education, social and professional insertion and psychological impact. - To improve appropriate treatment strategies during childhood and the transition into adulthood. - To reassess the long-term effectiveness of growth hormone treatment for growth hormone deficiency. Several questions remain outstanding, in addition to high cost, the effectiveness on final height as well as the quality of life for a significant number of patients. - To monitor long-term tolerance with particular focus on tumour risk null France Individuals Patients population Male Female Infant, Newborn (birth to 28 days) Child (6 to 12 years) Patients treated with recombinant growth hormone in childhood from 1985 to 1997. Participant-reported health data Paraclinical data (non-biological) : Imaging Health event/morbidity Health event/mortality Health care consumption and services Quality of life/health perception Other Through organizations (health services or institutions schools businesses etc.) [10000-20000[ individuals Self-administered questionnaire Interview with the participant (including clinical) Observational Study Observational Study Cohort study 10 489 Unknown Restricted access To be decided if data may be used by academic teams. Access on specific project only