CADASIL patient cohort FRESH-PEF60170-en Hugues CHABRIAT CADASIL patient cohort CADASIL FRESH-PEF60170-en 60170 FRESH-PEF60170 Hugues CHABRIAT ASSISTANCE PUBLIQUE HOPITAUX DE PARIS (AP-HP) Epidemiology France Portal (PEF) association DE RECHERCHE EN NEUROLOGIE VASCULAIRE (ARNEVA) CADASIL FRANCE MINISTERE DU TRAVAIL, DE LA SANTE, DES SOLIDARITES ET DES FAMILLES CENTRE DE MALADIES RARES null Hugues;CHABRIAT cognitive decline mobility impairment migraine ischaemic stroke epileptic seizure Health episodes apathy hospitalisation health system Neurology Socio-demographic and economic determinants: Employment Socio-demographic and economic determinants General objective: prospective study of patients with Notch 3 gene mutation thought to cause CADASIL: research into prognostic factors and useful markers for preventative treatment trial. Secondary objectives: - To determine clinical-radiological correlations - Modifying factors of clinical phenotype and MRI studies - Prognostic and progressive factors - Clinical phenotype variability - Natural history of disease null France Ile-de-France Individuals Patients population Male Female Aged, 80 and over (80 years and more) Adult patients with Notch 3 genetic mutation thought to cause CADASIL Clinical data Biological data Paraclinical data (non-biological) : Imaging Health event/morbidity Health event/mortality Other Through organizations (health services or institutions schools businesses etc.) < 500 individuals Converting or copying information into a structured record Interview with the participant (including clinical) Observational Study Observational Study Cohort study 250 Unknown Restricted access To be decided by scientist in charge Access on specific project only