Genomics of Resistance/Susceptibility to HIV-1 Infection FRESH-PEF60149-en Jean-François ZAGURY Genomics of Resistance/Susceptibility to HIV-1 Infection GRIV FRESH-PEF60149-en 60149 FRESH-PEF60149 Jean-François ZAGURY CONSERVATOIRE NATIONAL DES ARTS ET METIERS (CNAM) Epidemiology France Portal (PEF) AGENCE NATIONALE DE RECHERCHES SUR LE SIDA ET LES HEPATITES VIRALES (ANRS MIE) MINISTERE DE L’ENSEIGNEMENT SUPERIEUR, DE LA RECHERCHE ET DE L’ESPACE SIDACTION (ECS) null Jean-François;ZAGURY CD4 + lymphocyte count non-progressors viral load clinical events rapid release documented seroconversion Health episodes seropositivity follow-up Infectious disease medicine Biological determinants: Genetic predisposition Biological determinants General objective: to determine genetic polymorphisms (variations) which promote/suppress infection and/or progression to AIDS. Secondary objective: to understand the molecular mechanisms of the pathogenesis of HIV-1 infection and the rational development of new treatment or diagnostic strategies resulting from this. null France Individuals Patients population Male Female Young Adult (19 to 24 years) Adult (25 to 44 years) Middle Aged (45 to 64 years) Non-progressors: untreated individuals that have been seropositive for over 8 years with no clinical signs and with CD4 + lymphocytes above 500/mm3 Rapid progressors: subjects with CD4 + lymphocytes that dropped below 300/mm3 within 3 years after seroconversion Clinical data Participant-reported health data Biological data Health event/morbidity Health event/mortality Other Through organizations (health services or institutions schools businesses etc.) < 500 individuals Interview with the participant (including clinical) Observational Study Observational Study Cohort study 400 Unknown Restricted access Data may be used by academic teams. To be decided if data may be used by industrial teams Data may be used by academic teams Access permitted for collaboration with other teams working in the same field of AIDS genomics. To be decided if data may be used by industrial teams. Access on specific project only