Inflammatory Diseases in Paediatric Rheumatology FRESH-PEF60138-en Pierre QUARTIER-DIT-MAIRE Inflammatory Diseases in Paediatric Rheumatology CEMARA FRESH-PEF60138-en 60138 FRESH-PEF60138 Pierre QUARTIER-DIT-MAIRE INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ASSISTANCE PUBLIQUE HOPITAUX DE PARIS (AP-HP) Epidemiology France Portal (PEF) null Pierre;QUARTIER-DIT-MAIRE adverse events life-threatening sequelae embryonic/foetal impairment neoplasia Health episodes death hospitalisation Paediatrics Rheumatology Menopause Biological determinants: Genetic predisposition Biological determinants General objective: To evaluate the risk of the occurrence of serious adverse events under or after exposure to prescribed biotherapy for rheumatoid arthritis. The selected population consists of a growing proportion of patients exposed to early introductory biotherapy from childhood (TNF-Alpha antagonists, IL-1, IL-6, anti-CD20, CTLA-4Ig etc.), sometimes in combination with immunosuppressants Secondary objectives: 1/ To simultaneously assess the risk of the occurrence of serious adverse events (SAE) in the absence of biotherapy for the entire paediatric rheumatology cohort. 2/ To assess the risk of SAEs in the presence or absence of biotherapy for main sub-cohorts: juvenile idiopathic arthritis, paediatric autoimmune diseases, systemic vasculitis and childhood collagen diseases including lupus. 3/ To describe progressive characteristics and treatment of these patients in more detail. 4/ To further basic, clinical and epidemiological studies by creating a biobank and connections with other cohorts and registries 5/ To promote the assessment of medical practices and the application of national protocol recommendations for diagnosis and care. null France Individuals Patients population Male Female Child (6 to 12 years) Patients included in the CEMARA database must have a diagnosis relevant to the label "juvenile arthritis" in the rare disease reference centre = inflammatory paediatric rheumatology diseases identified in the CEMARA thesaurus (and Orphanet thesauraus) belonging to one of the following 4 categories: juvenile idiopathic arthritis, other juvenile arthritis, paediatric autoinflammatory diseases, systemic diseases and paediatric vasculitis Clinical data Health event/morbidity Health event/mortality Other Through organizations (health services or institutions schools businesses etc.) [1000-10000[ individuals Interview with the participant (including clinical) Observational Study Observational Study Cohort study 1068 Unknown Restricted access Data may be used by academic teams. Data may not be used by industrial teams Contractual access. Access on specific project only