Cohort of Children with Alpha 1 Antitrypsin Deficiency. FRESH-PEF60120-en Alain LACHAUX Cohort of Children with Alpha 1 Antitrypsin Deficiency. DEFI-ALPHA FRESH-PEF60120-en 60120 FRESH-PEF60120 Alain LACHAUX Mathias RUIZ HOSPICES CIVILS DE LYON (HCL) Epidemiology France Portal (PEF) LABORATOIRE FRANCAIS DU FRACTIONNEMENT ET DES BIOTECHNOLOGIES (LFB) MINISTERE DU TRAVAIL, DE LA SANTE, DES SOLIDARITES ET DES FAMILLES null Lioara;MIRON-RESTIER Mathias;RUIZ occurrence of complications ultrasound/Doppler ultrasound FibroScan fibrosis test endoscopy and oesophageal video capsule platelets transaminase and gamma-GT Health episodes factors liver transplantation Hepatology Diseases of the digestive system Biological determinants: Genetic predisposition Biological determinants General objective: To investigate prognostic hepatic factors in A1AT deficient children. Investigation of factors associated with onset of complications: portal hypertension and its complications, severe liver failure, liver transplantation, abnormalities during respiratory function exploration. Secondary objectives: - To organise an active homogenised cohort follow-up. - To ensure that new cases are recorded. - To create a reference network in order to homogenise treatment. null France Individuals Patients population Male Female Child, Preschool (2 to 5 years) Child (6 to 12 years) Children with DA1AT born after 1989, regardless of phenotype. DA1AT is defined as an alpha-1 antitrypsin deficiency lower than 1,1 g/l, and type ZZ or SZ MZ, MS, SS, detected by participating centres (service follow-up, or detected by corresponding neonatal services, family surveys, patient associations or dosage laboratories in the geographical area of participating services). Clinical data Biological data Paraclinical data (non-biological) : Imaging Health event/morbidity Health event/mortality Other Through organizations (health services or institutions schools businesses etc.) < 500 individuals Interview with the participant (including clinical) Medico-administrative database Observational Study Observational Study Cohort study 180 Unknown Restricted access To be decided if data may be used by industrial teams Access for potentially interested LFB laboratories To be decided if data may be used by academic teams. Access on specific project only