Study of genetic factors implied into autism and related disorders FRESH-PEF60112-en Marion LEBOYER Study of genetic factors implied into autism and related disorders AUTISME FRESH-PEF60112-en 60112 FRESH-PEF60112 Marion LEBOYER Thomas BOURGERON INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) Epidemiology France Portal (PEF) ASSISTANCE PUBLIQUE HOPITAUX DE PARIS (AP-HP) FONDATION D ENTREPRISE ORANGE Fondation FondaMental INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) null Marion;LEBOYER Thomas;BOURGERON Neurology Psychiatry Autism spectrum disorder Biological determinants: Genetic predisposition Biological determinants Identify genetic factors implied into autism and related disorders. Secondary objectives: - Carry on the recruitment of patients and related ; - Identify and take an inventory of secondary autism spectrum disorder forms to genetic diseases ; - Study clinical, cognitive and biomedical phenotypes of patients and relatives ; - Carry on the study of genes implied in autism ; - Study genotype/phenotype correlations. null France Individuals Patients population Female Child (6 to 12 years) Of patients or subjects called proposers : - patient with autism, filling DSM-IV (American Psychiatric Association, 1994) diagnostic criteria, and ADI-R (Autism Diagnostic interview-revised, Lord et Coll., 1994) for autism Or Patient with Asperger syndrome, filling DM-IV criteria, as well as ASDI (Asperger Syndrome Diagnostic Interview, Gillberg et Coll., 2001) for Asperger syndrome Or Patient with TSA-NS filling DSM-IV diagnostic criteria; - At least 2 years old, with no further age limit ; - Somatic condition compatible with a blood sample; - Social security scheme membership - Informed consent signature. Of first degree relatives (parents, brothers and sisters): - Informed consent signature - Somatic and intellectual condition compatible with a blood sample - Social security scheme membership Of adult controls: - Aged between 18 and 50; - Being Caucasian; - Absence of psychiatric pathology, verified with DIGS (Diagnostic Interview for Genetic Studies, Nurnberger et coll., 1994) for adults; - Somatic and intellectual condition compatible with a blood sample - Informed consent signature - Social security scheme membership Of child controls: - At least 2 years old, with no further age limit; - Being Caucasian; - Beneficiary of social security scheme; - Absence of psychiatric pathology verified with Kiddie-sads (kiddie schedule for affective disorders and schizophrenia for school-age children, Orvaschel et Coll., 1982); - Parents or legal guardians informed consent signature Clinical data Participant-reported health data Biological data Paraclinical data (non-biological) : Imaging Coherence request during after computer data entry; Missing data management; Doctors remainders for follow-up visits; Patients receive written information about the use of their data. Health event/morbidity Health event/mortality Other Through organizations (health services or institutions schools businesses etc.) [1000-10000[ individuals Self-administered questionnaire Interview with the participant (including clinical) Observational Study Observational Study Case-control study 1800 Completed study Restricted access Possible data utilization by academic teams. Data exploitation not available for industry sectors. Access condition : international USA collaboration (Autism Genome Project) leading to publications. Access on specific project only