EPPIII - Cardiac rhythm, baroreflex and cardiovascular morbi-mortality on general population. The Paris Prospective Study III FRESH-PEF60095-en Jean-Philippe EMPANA EPPIII - Cardiac rhythm, baroreflex and cardiovascular morbi-mortality on general population. The Paris Prospective Study III EPP III FRESH-PEF60095-en 60095 FRESH-PEF60095 Jean-Philippe EMPANA INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) Epidemiology France Portal (PEF) EUROPEAN COMMISSION RESEARCH GIS-INSTITUT POUR LA RECHERCHE EN SANTE PUBLIQUE (IRESP) AGENCE NATIONALE DE LA RECHERCHE (ANR) FONDATION POUR LA RECHERCHE MEDICALE MINISTERE DU TRAVAIL, DE LA SANTE, DES SOLIDARITES ET DES FAMILLES null Jean-Philippe;EMPANA Marie;PERIER observational cohort cardiovascular disease sudden cardiac death blood biomarkers carotid rigidity echotracking epidemiology Cardiology and vascular medicine Socio-demographic and economic determinants Biological determinants: Genetic predisposition Behavioral determinants Behavioral determinants: Eating habits Healthcare system determinants: Use of care Socio-demographic and economic determinants: Employment Biological determinants Healthcare system determinants To assess the predictive value of novel biomarkers of various nature for incident cardiovascular diseases (CVD). Biomarkers include vascular ageing biomarkers derived from carotid echotracking, rythmic biomarkers and blood biomarkers. CVD include adjudicated sudden cardiac arrest, coronary heart disease, stroke, heart failure, peripheral artery disease and arterial aneurysms; with an extension to cancer. null France Ile-de-France Individuals General population Male Female Middle Aged (45 to 64 years) Aged (65 to 79 years) Men and women between 50 and 75 years old, having a French general Social Security regime and consulting for an health check at the Paris preventive and clinical investigation center, voluntaries for the study (written consent), understanding French and accepting genetic analysis. Clinical data Participant-reported health data Biological data Socio-demographic data Paraclinical data (non-biological) : Imaging Paraclinical data (non-biological) : Function testing Coherence request after computer data entry. Subjects remainders for follow-up visits. Quality audit realization: external audits every year. Other quality procedures: regular audit (once a month by Inserm). Patients are informed about the use of their data. Health event/morbidity Health event/mortality Quality of life/health perception Other Through organizations (health services or institutions schools businesses etc.) Population database for statistical purposes [1000-10000[ individuals Self-administered questionnaire Medico-administrative database Observational Study Observational Study Cohort study 10166 Unknown Restricted access Possible data utilization by academic teams: access conditions provided by a written convention. Possible use for industrial sector: contractual access conditions. Access on specific project only