Characterisation of Age-Related Bone Loss In Women FRESH-PEF60069-en Roland CHAPURLAT Characterisation of Age-Related Bone Loss In Women OFELY FRESH-PEF60069-en 60069 FRESH-PEF60069 Pierre DELMAS INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) Epidemiology France Portal (PEF) AMGEN MSD FRANCE PREVENTION DES MALADIES OSSEUSES (PMO) null Pierre;DELMAS osteoporosis clinical risk factors falls activity physical muscular strength menopausal status anthropometric family history osteoarthritis Health episodes fractures treatment Endocrinology Geriatrics Behavioral determinants Environmental determinants: Climate Socio-demographic and economic determinants Healthcare system determinants: Use of care Environmental determinants Healthcare system determinants General objective: Prospective evaluation characterising age-related bone loss normal women at different skeletal sites. Secondary objectives are: - to identify the clinical, biochemical and hormonal determinants of bone loss and to predict the rate of bone loss using biochemical markers. To investigate fracture determinants in menopausal women (bone loss, clinical, biochemical and hormonal factors as well as bone microarchitecture) - to study osteoarthritis: the relationship between osteoarthritis and osteoporosis, osteoarthritis and specific cartilage markers and longitudinal osteoarthritic development in the knees for the entire cohort null France Auvergne Rhône-Alpes Individuals General population Female Adult (25 to 44 years) Middle Aged (45 to 64 years) Aged (65 to 79 years) Women between 30 and 90 years old, registered with the MGEN section in Rhône, living in Rhône and the surrounding départements. Clinical data Participant-reported health data Biological data Paraclinical data (non-biological) : Imaging Health event/morbidity Health event/mortality Other Population database for statistical purposes [1000-10000[ individuals Self-administered questionnaire Interview with the participant (including clinical) Observational Study Observational Study Cohort study 1207 Unknown Restricted access Data may be used by academic teams Data may be used by industrial teams Access on specific project only