Cohort of Patients with HIV Associated Lymphoma FRESH-PEF60062-en Caroline BESSON Cohort of Patients with HIV Associated Lymphoma ANRS CO16 LYMPHOVIR FRESH-PEF60062-en 60062 FRESH-PEF60062 Caroline BESSON Dominique COSTAGLIOLA AGENCE NATIONALE DE RECHERCHES SUR LE SIDA ET LES HEPATITES VIRALES (ANRS MIE) Epidemiology France Portal (PEF) AGENCE NATIONALE DE RECHERCHES SUR LE SIDA ET LES HEPATITES VIRALES (ANRS MIE) null Caroline;BESSON event-free survival Health episodes overall survival quality of life Oncology Cardiology and vascular medicine Clinical immunology Infectious disease medicine Biological determinants: Genetic predisposition Biological determinants General objective: to better understand the physiopathology of non-Hodgkin lymphoma (NHL) and Hodgkin lymphoma (HL) associated with HIV by studying, on the one hand, interaction between Epstein-Barr virus (EBV) and HIV infection from a virological and immunological viewpoint and, on the other hand, the role of chronic antigen stimulation. Secondary objectives: - Clinical and histological characterisation of lymphoma; - to undertake an observational study on the treatment and outcome for these patients in terms of antiretroviral therapy; - to create a forum concerning therapeutic care for these patients; - To enable "Lymphoma and HIV" studies developed by the ANRS group: (1) Clinical: (a) To define prognostic factors for unfavourable progression of NHL and HL (b) To develop target treatment consensus according to histology and clinical presentation for patients included in the cohort (2) Anatomical and clinical: to characterise lymphoproliferations and investigate the presence and reactivation of EBV in these tumours (3) Immunological: to study anti-EBV immune T cell response and their role in the pathophysiology of EBV-related lymphomas, to characterise the activation status of circulating B cells (4) Virological: to quantify viral load and anti-EBV antibody titres, to genotype EBV variants for HL patients, to study the replication of EBV in B lymphocyte memory, to investigate the interaction of TGF-induced EBV replication and cell survival in tumour cells infected by EBV (5) Molecular: to study the "microsatellite instability" (MSI) phenotype of these tumours. null France Individuals Patients population Male Female Young Adult (19 to 24 years) Adult (25 to 44 years) Middle Aged (45 to 64 years) Adults (18 years old); - infected by HIV-1 or HIV-2; - NHL or HL diagnosis or relapse (including cerebral lymphoma); - who have given clear and written consent. Clinical data Participant-reported health data Biological data Paraclinical data (non-biological) : Imaging Health event/morbidity Health event/mortality Quality of life/health perception Other Through organizations (health services or institutions schools businesses etc.) < 500 individuals Self-administered questionnaire Interview with the participant (including clinical) Observational Study Observational Study Cohort study 150 Unknown Restricted access Data may be used by academic teams. Data may not be used by industrial teams. Access to all or part of the study database will be specified by the scientific council and subject to the agreement of the sponsor. Access on specific project only