Prospective Breast and Ovarian Genetic Study: genetic predisposition to breast and ovarian cancer: a prospective study of BRCA mutation carriers FRESH-PEF60053-en Catherine NOGUES Prospective Breast and Ovarian Genetic Study: genetic predisposition to breast and ovarian cancer: a prospective study of BRCA mutation carriers GENEPSO FRESH-PEF60053-en 60053 FRESH-PEF60053 Catherine NOGUES Emmanuelle FOURME INSTITUT CURIE Epidemiology France Portal (PEF) FONDATION DE FRANCE LIGUE NATIONALE CONTRE LE CANCER (LNCC) null Catherine;NOGUES Emmanuelle;FOURME BRCA gene mutation standardised collection prospective follow-up Health events death Oncology Biological determinants: Genetic predisposition Biological determinants General objective: to form a cohort of BRCA gene mutation carriers for standardised data collection and to establish a prospective follow-up over 10 years. Treatment for families can be improved by resolving certain questions (projects with associated INSERM teams): 1) what is the risk of developing breast and/or ovarian cancer for gene mutation carriers during their lifetime? 2) are cancer risks modified by environmental factors (in particular medical radiation), hormonal factors (endogenous or exogenous), or other genetic factors? 3) should the same parameters be used to evaluate the prognosis of sporadic cancer? 4) what is the psychological and social impact for people with a known predisposition to breast and/or ovarian cancer? null France Individuals Patients population Male Female Young Adult (19 to 24 years) Adult (25 to 44 years) Middle Aged (45 to 64 years) Adult subjects with no mental disability who are BRCA genetic mutation carriers Clinical data Participant-reported health data Biological data Paraclinical data (non-biological) : Imaging Health event/morbidity Health event/mortality Other Through organizations (health services or institutions schools businesses etc.) [1000-10000[ individuals Self-administered questionnaire Interview with the participant (including clinical) Observational Study Observational Study Cohort study 1425 Unknown Restricted access Data may be used by academic teams Data may be used by industrial teams Access on specific project only