{"doc_desc":{"title":"Etiopathogenesis of psychiatric disorders in the elderly","idno":"FRESH-PEF60045-en","producers":[{"name":"Karen RITCHIE","affiliation":"INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)"}]},"study_desc":{"title_statement":{"idno":"FRESH-PEF60045-en","IDno":{"metadata_no":[{"agency":"PEF","code":"60045"},{"agency":"FReSH","code":"FRESH-PEF60045"}]},"title":"Etiopathogenesis of psychiatric disorders in the elderly","alternate_title":"ESPRIT-VIE"},"study_authorization":{"agency":[]},"authoring_entity":[{"name":"Karen;RITCHIE","firstname":"Karen","lastname":"RITCHIE","type":"investigator","extlink":[{"title":"ROR","uri":"https:\/\/ror.org\/02vjkv261","role":"organisation id"},{"title":"SIREN","uri":"180036048","role":"organisation id"}],"email":"karen.ritchie@inserm.fr","affiliationName":"INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 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theme","extLink":[{"title":"ESV","uri":"http:\/\/data.europa.eu\/8mn\/euroscivoc\/3de50dee-da1c-4791-a386-56bca24a5fed"},{"title":"MeSH","uri":"http:\/\/id.nlm.nih.gov\/mesh\/D011570"}]},{"topic":"Mental, behavioural or neurodevelopmental disorders","vocab":"cim-11","extLink":[{"uri":"http:\/\/id.who.int\/icd\/entity\/334423054","title":"CIM-11"}]},{"topic":"Biological determinants: Genetic predisposition","vocab":"health determinant"},{"topic":"Behavioral determinants","vocab":"health determinant"},{"topic":"Healthcare system determinants: Use of care","vocab":"health determinant"},{"topic":"Biological determinants","vocab":"health determinant"},{"topic":"Healthcare system determinants","vocab":"health determinant"}],"purpose":"To study the etiopathogenesis of psychiatric disorders in the elderly by identifying associated risk factors throughout life in elderly people with previous psychiatric history. - to identify depressive symptom subtypes regardless of current nosology; - to describe age-related changes in stress reactivity; - to assess the validity of current gene interaction\/stress models for depression described in young subjects for elderly subjects; - to evaluate the usefulness of complete genome exploration based on haplotypes as well as a pilot study of clinical pools based on symptom severity; - to find the most relevant etiological models derived from multiple risk factors and interaction to explain the onset of illness and symptom severity; - to suggest future intervention and prevention strategies based on these models.","abstract":"","coll_dates":[{"start":"1999-01-01","end":"2012-01-01"}],"nation":[{"name":"France","abbreviation":"fr","extLink":{"vocab":"ISO","vocabURI":"fr"}}],"geog_coverage":"['Occitanie']","analysis_unit":"Individuals","universe":"{\n    \"level_sex_clusion_I\": [\n        {\n            \"value\": \"Male\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": 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