Etiopathogenesis of psychiatric disorders in the elderly FRESH-PEF60045-en Karen RITCHIE Etiopathogenesis of psychiatric disorders in the elderly ESPRIT-VIE FRESH-PEF60045-en 60045 FRESH-PEF60045 Karen RITCHIE INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) Epidemiology France Portal (PEF) NOVARTIS PHARMA SAS null Karen;RITCHIE Etiopathogenesis the elderly psychiatric history symptomatology nosology stress reactivity risk factors Geriatrics Neurology Psychiatry Mental, behavioural or neurodevelopmental disorders Biological determinants: Genetic predisposition Behavioral determinants Healthcare system determinants: Use of care Biological determinants Healthcare system determinants To study the etiopathogenesis of psychiatric disorders in the elderly by identifying associated risk factors throughout life in elderly people with previous psychiatric history. - to identify depressive symptom subtypes regardless of current nosology; - to describe age-related changes in stress reactivity; - to assess the validity of current gene interaction/stress models for depression described in young subjects for elderly subjects; - to evaluate the usefulness of complete genome exploration based on haplotypes as well as a pilot study of clinical pools based on symptom severity; - to find the most relevant etiological models derived from multiple risk factors and interaction to explain the onset of illness and symptom severity; - to suggest future intervention and prevention strategies based on these models. null France Occitanie Individuals Patients population Male Female Aged (65 to 79 years) Aged, 80 and over (80 years and more) Men and women aged 65 and older included in the Montpellier and surrounding district electoral register (cohort of subjects who lived through war (First and Second World War, Algerian War, Spanish Civil War) Clinical data Participant-reported health data Biological data Paraclinical data (non-biological) : Imaging Health event/morbidity Health event/mortality Other Through organizations (health services or institutions schools businesses etc.) [1000-10000[ individuals Self-administered questionnaire Interview with the participant (including clinical) Observational Study Observational Study Cohort study 2259 Unknown Restricted access Data may be used by academic teams Data may be used by industrial teams Access on specific project only