{"doc_desc":{"title":"\u00c9tiopathog\u00e9nie des troubles psychiatriques en population ag\u00e9e","idno":"FRESH-PEF60045-fr","producers":[{"name":"Karen RITCHIE","affiliation":"INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)"}]},"study_desc":{"title_statement":{"idno":"FRESH-PEF60045-fr","IDno":{"metadata_no":[{"agency":"PEF","code":"60045"},{"agency":"FReSH","code":"FRESH-PEF60045"}]},"title":"\u00c9tiopathog\u00e9nie des troubles psychiatriques en population ag\u00e9e","alternate_title":"ESPRIT-VIE"},"study_authorization":{"agency":[{"name":"CNIL"},{"name":"CPP"}]},"authoring_entity":[{"name":"Karen;RITCHIE","firstname":"Karen","lastname":"RITCHIE","type":"investigator","extlink":[{"title":"ROR","uri":"https:\/\/ror.org\/02vjkv261","role":"organisation id"},{"title":"SIREN","uri":"180036048","role":"organisation id"}],"email":"karen.ritchie@inserm.fr","affiliationName":"INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 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associ\u00e9s au cours de la vie, chez des personnes \u00e2g\u00e9es qui ont leur histoire psychiatrique derri\u00e8re eux. - identifier les sous types de la symptomatologie d\u00e9pressive ind\u00e9pendamment de la nosologie actuelle; - d\u00e9crire les modifications de la r\u00e9activit\u00e9 au stress li\u00e9e a l'\u00e2ge; - examiner la validit\u00e9 chez le sujet \u00e2g\u00e9 des mod\u00e8les actuels d'interaction g\u00e8ne\/stress de d\u00e9pression d\u00e9crits chez le sujet jeune; - \u00e9valuer l'utilit\u00e9 de l'exploration compl\u00e8te du g\u00e9nome sur la base d'haplotypes et d'une \u00e9tude pilote de pools cliniques bas\u00e9e sur la s\u00e9v\u00e9rit\u00e9 des sympt\u00f4mes; - trouver les mod\u00e8les \u00e9tiologiques d\u00e9riv\u00e9s de multiples facteurs de risques et d'interaction les plus pertinents pour expliquer le d\u00e9but de la maladie et la s\u00e9v\u00e9rit\u00e9 des sympt\u00f4mes; - sugg\u00e9rer sur la base de ces mod\u00e8les de futures strat\u00e9gies de pr\u00e9vention et d'intervention.","abstract":"","coll_dates":[{"start":"1999-01-01","end":"2012-01-01"}],"nation":[{"name":"France","abbreviation":"fr","extLink":{"vocab":"ISO","vocabURI":"fr"}}],"geog_coverage":"['Occitanie']","analysis_unit":"Individus","universe":"{\n    \"level_sex_clusion_I\": [\n        {\n            \"value\": \"Masculin\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D008297\"\n            }\n        },\n        {\n            \"value\": \"F\u00e9minin\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D005260\"\n            }\n        }\n    ],\n    \"level_age_clusion_I\": [\n        {\n            \"value\": \"Personne \u00e2g\u00e9e (65 \u00e0 79 ans)\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": 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