French Cohort Study on Ataxia Telangiectasia FRESH-PEF60031-en Nadine ANDRIEU French Cohort Study on Ataxia Telangiectasia CoF-AT FRESH-PEF60031-en 60031 FRESH-PEF60031 Nadine ANDRIEU INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) Epidemiology France Portal (PEF) ELECTRICITE DE FRANCE (EDF) FONDATION DE FRANCE FONDATION ENTREPRISE MGEN SANTE PUBLIQUE (FSP MGEN) INSTITUT CURIE INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) LIGUE NATIONALE CONTRE LE CANCER (LNCC) MINISTERE DE L’ENSEIGNEMENT SUPERIEUR, DE LA RECHERCHE ET DE L’ESPACE null Nadine;ANDRIEU Health episodes cancer environment Oncology Biological determinants: Genetic predisposition Biological determinants The objectives of the cohort involving women related to a child suffering from ataxia telangiectasia (AT) are multi-layered: 1. To monitor female relatives for early detection of breast cancer (BC). 2. To estimate the risk of cancer associated with AT genes with a focus on BC risk. To investigate the role of potential modifying factors for this risk such as radiation, hormonal factors etc. 3. To investigate the natural history of BC in AT heterozygous women null Belgium Luxembourg France Individuals General population Female Young Adult (19 to 24 years) Adult (25 to 44 years) Middle Aged (45 to 64 years) Breast cancer free women, of legal age and related to a child with ataxia telangiectasia-: mothers, sisters, aunts, grandmothers, maternal and paternal cousins. Recruited from families who participated in the first previous retrospective study by the team and new families contacted through treating physicians (paediatricians, neuro-paediatricians ...), geneticists, the AT research association (APRAT), Orphanet (information server on rare diseases and orphan drugs) and CEREDIH (reference centre for hereditary immunodeficiencies). Clinical data Participant-reported health data Biological data Paraclinical data (non-biological) : Imaging Health event/morbidity Health event/mortality Other Through organizations (health services or institutions schools businesses etc.) < 500 individuals Self-administered questionnaire Interview with the participant (including clinical) Observational Study Observational Study Cohort study 391 (2013) Unknown Restricted access Data may be used by academic teams Data may not be used by industrial teams Access on specific project only