<?xml version="1.0" encoding="UTF-8"?>
<codeBook version="2.5" ID="FRESH-PEF60014-en" xml-lang="en" xmlns="ddi:codebook:2_5" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="ddi:codebook:2_5 https://ddialliance.org/Specification/DDI-Codebook/2.5/XMLSchema/codebook.xsd">
<docDscr>
  <citation>
    <titlStmt>
      <titl>Cohort Study of Uranium Miners in France</titl>
      <IDNo>FRESH-PEF60014-en</IDNo>
    </titlStmt>
    <prodStmt>
      <producer abbr="" affiliation="AUTORITE DE SURETE NUCLEAIRE ET DE RADIOPROTECTION (ASNR)" role="">Estelle RAGE</producer>
    </prodStmt>
    <verStmt>
      <version></version>
    </verStmt>
  </citation>
</docDscr>
<stdyDscr>
  <citation>
    <titlStmt>
      <titl>
                Cohort Study of Uranium Miners in France            </titl>
      <altTitl>
                    MINEURS D'URANIUM                </altTitl>
      <IDNo agency="FReSH-lang">
                FRESH-PEF60014-en            </IDNo>
      <IDNo agency="PEF">
                    60014                </IDNo>
      <IDNo agency="FReSH">
                    FRESH-PEF60014                </IDNo>
    </titlStmt>
    <rspStmt>
      <AuthEnty>
                    Dominique LAURIER                                                                                                                            </AuthEnty>
      <AuthEnty affiliation="AUTORITE DE SURETE NUCLEAIRE ET DE RADIOPROTECTION (ASNR)">
        <ExtLink title="ROR" URI="https://ror.org/04dbtaf18" role="organisation id"/>
        <ExtLink title="SIREN" URI="130001803" role="organisation id"/>
      </AuthEnty>
      <AuthEnty>
                    Klervi LEURAUD                                                                                                                            </AuthEnty>
      <AuthEnty affiliation="AUTORITE DE SURETE NUCLEAIRE ET DE RADIOPROTECTION (ASNR)">
        <ExtLink title="ROR" URI="https://ror.org/04dbtaf18" role="organisation id"/>
        <ExtLink title="SIREN" URI="130001803" role="organisation id"/>
      </AuthEnty>
      <AuthEnty>
                    Estelle RAGE                                                                                                                            </AuthEnty>
      <AuthEnty affiliation="AUTORITE DE SURETE NUCLEAIRE ET DE RADIOPROTECTION (ASNR)">
        <ExtLink title="ROR" URI="https://ror.org/04dbtaf18" role="organisation id"/>
        <ExtLink title="SIREN" URI="130001803" role="organisation id"/>
      </AuthEnty>
      <othId affiliation="" type="collaboration">
                                    </othId>
    </rspStmt>
    <prodStmt>
      <producer role="sponsor">
                                            AREVA                    
                                    </producer>
      <prodPlac>
                Epidemiology France Portal (PEF)            </prodPlac>
      <fundAg>
                                            EUROPEAN COMMISSION RESEARCH                    
                                    </fundAg>
      <fundAg>
                                            AREVA                    
                                    </fundAg>
      <fundAg>
                                            AUTORITE DE SURETE NUCLEAIRE ET DE RADIOPROTECTION (ASNR)                    
                                    </fundAg>
    </prodStmt>
    <distStmt>
      <distrbtr abbr="null">
                    null</distrbtr>
      <contact affiliation="AUTORITE DE SURETE NUCLEAIRE ET DE RADIOPROTECTION (ASNR)" email="dominique.laurier@irsn.fr">
                    Dominique;LAURIER
                                            <ExtLink title="ROR" URI="https://ror.org/04dbtaf18" role="organisation id"/>
                                            <ExtLink title="SIREN" URI="130001803" role="organisation id"/>
                                    </contact>
      <contact affiliation="AUTORITE DE SURETE NUCLEAIRE ET DE RADIOPROTECTION (ASNR)" email="klervi.leuraud@irsn.fr">
                    Klervi;LEURAUD
                                            <ExtLink title="ROR" URI="https://ror.org/04dbtaf18" role="organisation id"/>
                                            <ExtLink title="SIREN" URI="130001803" role="organisation id"/>
                                    </contact>
      <contact affiliation="AUTORITE DE SURETE NUCLEAIRE ET DE RADIOPROTECTION (ASNR)" email="estelle.rage@irsn.fr">
                    Estelle;RAGE
                                            <ExtLink title="ROR" URI="https://ror.org/04dbtaf18" role="organisation id"/>
                                            <ExtLink title="SIREN" URI="130001803" role="organisation id"/>
                                    </contact>
      <depDate date="2026-06-16"/>
      <distDate date="2026-06-16"/>
    </distStmt>
    <biblCit format="">
            </biblCit>
    <holdings URI="null"/>
    <notes> </notes>
  </citation>
  <stdyInfo>
    <studyBudget/>
    <subject>
      <keyword vocab="" vocabURI="">
                    Death</keyword>
      <keyword vocab="" vocabURI="">
                    lung</keyword>
      <keyword vocab="" vocabURI="">
                    cancer</keyword>
      <keyword vocab="" vocabURI="">
                    radon</keyword>
      <keyword vocab="" vocabURI="">
                    tobacco</keyword>
      <keyword vocab="" vocabURI="">
                    alpha-risk</keyword>
      <keyword vocab="" vocabURI="">
                    health</keyword>
      <keyword vocab="" vocabURI="">
                    environment</keyword>
      <topcClas vocab="health theme">
                        Oncology                                                        <ExtLink title="ESV" URI="http://data.europa.eu/8mn/euroscivoc/5784b7f1-c7ce-49d9-9f38-aebcda0ff41d"/>
                                                            <ExtLink title="MeSH" URI="http://id.nlm.nih.gov/mesh/D008495"/>
                                                </topcClas>
      <topcClas vocab="health theme">
                        Cardiology and vascular medicine                                                        <ExtLink title="ESV" URI="http://data.europa.eu/8mn/euroscivoc/4455c187-2f2f-4cd1-a4dd-449f59d73b39"/>
                                                            <ExtLink title="ESV" URI="http://data.europa.eu/8mn/euroscivoc/c42fc6ec-b216-4a24-9e9d-f5e781c175a0"/>
                                                            <ExtLink title="MeSH" URI="http://id.nlm.nih.gov/mesh/D002309"/>
                                                </topcClas>
      <topcClas vocab="health theme">
                        Public, environmental and occupational health                                                        <ExtLink title="ESV" URI="http://data.europa.eu/8mn/euroscivoc/b533acc2-aff1-4c65-80ca-5d5bee865ba9"/>
                                                            <ExtLink title="MeSH" URI="http://id.nlm.nih.gov/mesh/D004778"/>
                                                </topcClas>
      <topcClas vocab="health theme">
                        Pulmonary medicine                                                        <ExtLink title="ESV" URI="http://data.europa.eu/8mn/euroscivoc/f6e18c52-6087-4662-904c-5c4b8174e40e"/>
                                                            <ExtLink title="MeSH" URI="http://id.nlm.nih.gov/mesh/D015272"/>
                                                </topcClas>
      <topcClas vocab="health determinant">
                        Socio-demographic and economic determinants: Employment                    </topcClas>
      <topcClas vocab="health determinant">
                        Behavioral determinants                    </topcClas>
      <topcClas vocab="health determinant">
                        Behavioral determinants: Addiction                    </topcClas>
      <topcClas vocab="health determinant">
                        Socio-demographic and economic determinants                    </topcClas>
    </subject>
    <abstract contentType="purpose">Study on the increased risk of cancer, including lung cancer, after chronic exposure to ionising radiation, including alpha emitters (radon descendants, uranium dust). Professional cofactors and smoking are taken into account. Secondary objective: The cohort study benefits from high quality individual registration of exposure to various carcinogens on an annual basis, as well as long-term follow-up (over 20 years on average). All causes of death are recorded regularly. It is also possible to study risks other than cancer in this cohort, including the risk of cardiovascular or respiratory death. The extrapolation of risk per unit of exposure enables the assessment of low-dosage risk, at levels regularly encountered by some of the French population. This is especially true for the estimation of cancer risk per unit of radon exposure in the home.</abstract>
    <abstract contentType="abstract">null</abstract>
    <sumDscr>
      <collDate event="start" date="1946-01-01"/>
      <collDate event="end" date="2007-01-01"/>
      <nation abbr="fr">
                    France
                                            <concept vocab="ISO" vocabURI="fr"/>
                                    </nation>
      <geogUnit/>
      <anlyUnit>
                Individuals            </anlyUnit>
      <universe level="type" clusion="I">General population                    </universe>
      <universe level="sex" clusion="I">Male                                                            <concept vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D008297"/>
                                                    </universe>
      <universe level="sex" clusion="I">Female                                                            <concept vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D005260"/>
                                                    </universe>
      <universe level="age" clusion="I">Young Adult (19 to 24 years)                                                            <concept vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D055815"/>
                                                    </universe>
      <universe level="age" clusion="I">Adult (25 to 44 years)                                                            <concept vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D000328"/>
                                                    </universe>
      <universe level="age" clusion="I">Middle Aged (45 to 64 years)                                                            <concept vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D008875"/>
                                                    </universe>
      <universe level="age" clusion="I">Aged (65 to 79 years)                                                            <concept vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D000368"/>
                                                    </universe>
      <universe level="age" clusion="I">Aged, 80 and over (80 years and more)                                                            <concept vocab="MeSH" vocabURI="http://id.nlm.nih.gov/mesh/D000369"/>
                                                    </universe>
      <universe clusion="I">Having worked at least 1 year in the CEA-Areva Uranium Mines                    </universe>
      <dataKind>Participant-reported health data</dataKind>
    </sumDscr>
  </stdyInfo>
  <studyDevelopment>
    <developmentActivity type="primary evaluation">
      <description>Health event/morbidity
Health event/mortality
Health care consumption and services</description>
    </developmentActivity>
  </studyDevelopment>
  <method>
    <dataColl>
      <sampProc>Other                                                            <concept vocab="CESSDA" vocabURI="Other"/>
                                                    </sampProc>
      <sampleFrame>
        <frameUnit>
          <unitType>Population database for statistical purposes</unitType>
        </frameUnit>
      </sampleFrame>
      <targetSampleSize>
        <sampleSizeFormula>[1000-10000[ individuals                        </sampleSizeFormula>
      </targetSampleSize>
      <collMode>Self-administered questionnaire                                                            <concept vocab="CESSDA" vocabURI="SelfAdministeredQuestionnaire"/>
                                                    </collMode>
      <collMode>Interview with the participant (including clinical)                                                            <concept vocab="CESSDA" vocabURI="Interview"/>
                                                    </collMode>
    </dataColl>
    <notes>Observational Study</notes>
    <notes subject="research type">
                        Observational Study                    </notes>
    <notes subject="observational study method">
                        Cohort study                    </notes>
    <anlyInfo>
      <respRate>5 086</respRate>
    </anlyInfo>
    <stdyClas>Unknown</stdyClas>
  </method>
  <dataAccs>
    <setAvail>
      <avlStatus>
                            Metadata-only access                                                    </avlStatus>
    </setAvail>
  </dataAccs>
  <othrStdyMat>
    <relMat>Access on specific project only</relMat>
  </othrStdyMat>
</stdyDscr>
<dataDscr>
</dataDscr></codeBook>
