Research on Genetic and Environmental Factors of Asthma and Associated Phenotypes FRESH-PEF5689-en Valérie SIROUX Research on Genetic and Environmental Factors of Asthma and Associated Phenotypes EGEA FRESH-PEF5689-en 5689 FRESH-PEF5689 Valérie SIROUX INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) Epidemiology France Portal (PEF) null Valérie;SIROUX genetic lung function improvement environment health events aggravation Allergology Pulmonary medicine Unspecified asthma, uncomplicated Environmental determinants: Climate Biological determinants: Genetic predisposition Environmental determinants: Other Behavioral determinants Behavioral determinants: Eating habits Environmental determinants Healthcare system determinants: Use of care Socio-demographic and economic determinants: Employment Biological determinants Healthcare system determinants Socio-demographic and economic determinants General objective: to investigate genetic and environmental factors and their impact on asthma, as well as phenotypes associated with bronchial hyperresponsiveness and atopy. null France Individuals Patients population Male Female Child (6 to 12 years) Young Adult (19 to 24 years) Adult (25 to 44 years) Middle Aged (45 to 64 years) Aged (65 to 79 years) Asthmatic adults between 15 and 64 years of age and children (7-15 year old) born in France, and their parents. Selected family units with at least one blood relation (both parents, or one spouse and one child) in one of the five city "centres". Definition of disease characteristic criteria. - Case-controls: electoral registers, subjects monitored in surgery (adults + children) or in social security check-up clinics. Participant-reported health data Biological data Paraclinical data (non-biological) : Function testing Consistency request after electronic data is recorded. Internal quality audit and external quality audit carried out each year. Health event/morbidity Quality of life/health perception Other Through organizations (health services or institutions schools businesses etc.) Medical-administrative database (patients health insurance/mutual insurance) Disease and death registry [1000-10000[ individuals Self-administered questionnaire Interview with the participant (including clinical) Observational Study Observational Study Cohort study 2,120 individuals. Unknown Restricted access Data may be used by academic teams. Data may be used by industrial teams. Access on specific project only