{"doc_desc":{"title":"Etude transversale sur des femmes porteuses de mutation BRCA1\/2 : g\u00e8nes modificateurs des risques tumoraux","idno":"FRESH-PEF5321-fr","producers":[{"name":"Olga SINILNIKOVA-ERARD","affiliation":"UNIVERSITE DE LYON"}]},"study_desc":{"title_statement":{"idno":"FRESH-PEF5321-fr","IDno":{"metadata_no":[{"agency":"PEF","code":"5321"},{"agency":"FReSH","code":"FRESH-PEF5321"}]},"title":"Etude transversale sur des femmes porteuses de mutation BRCA1\/2 : g\u00e8nes modificateurs des risques tumoraux","alternate_title":"GEMO"},"study_authorization":{"agency":[{"name":"CNIL"}]},"authoring_entity":[{"name":"Olga;SINILNIKOVA-ERARD","firstname":"Olga","lastname":"SINILNIKOVA-ERARD","type":"investigator","extlink":[{"title":"ROR","uri":"https:\/\/ror.org\/01rk35k63","role":"organisation id"}],"email":"olga.sinilnikova@lyon.unicancer.fr","affiliationName":"UNIVERSITE DE LYON","PILabo":"INSERM\/CNRS\/CLB\/UNIVERSITE DE LYON\/HOSPICES CIVILS DE \/ Centre de Recherche en Canc\u00e9rologie UMR5286 CNRS \/ U1052 Inserm, Equipe \u00ab G\u00e9n\u00e9tique du cancer du sein \u00bbUnit\u00e9 Mixte de G\u00e9n\u00e9tique Constitutionnelle des Cancers Fr\u00e9quents, Hospices Civils de Lyon - Centre L\u00e9on B\u00e9rard","isContact":true},{"name":"Dominique;STOPPA-LYONNET","firstname":"Dominique","lastname":"STOPPA-LYONNET","type":"investigator","extlink":[{"title":"ROR","uri":"https:\/\/ror.org\/05f82e368","role":"organisation id"},{"title":"SIREN","uri":"130025737","role":"organisation id"}],"email":"","affiliationName":"UNIVERSITE PARIS CITE","PILabo":"INSTITUT CURIE\/INSERM\/UNIVERSITE PARIS \/ Centre de Recherche INSERM U830, D\u00e9partement de Biologie des tumeurs - Service G\u00e9n\u00e9tique","isContact":false}],"oth_id":[{"name":""}],"production_statement":{"prod_place":"Portail Epid\u00e9miologie France (PEF)","producers":[{"name":"UniCancer Group","extlink":[{"title":"ROR","uri":"https:\/\/ror.org\/04vhgtv41","role":"sponsor 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\u00e0 des modifications du risque tumoral et identifier au sein de nos \u00e9chantillons des femmes porteuses des all\u00e8les associ\u00e9s \u00e0 une augmentation ou \u00e0 une diminution du risque tumoral","abstract":"","coll_dates":[{"start":"2002-01-01"}],"nation":[{"name":"France","abbreviation":"fr","extLink":{"vocab":"ISO","vocabURI":"fr"}}],"geog_coverage":"","analysis_unit":"Individus","universe":"{\n    \"level_sex_clusion_I\": [\n        {\n            \"value\": \"F\u00e9minin\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D005260\"\n            }\n        }\n    ],\n    \"level_age_clusion_I\": [\n        {\n            \"value\": \"Adulte (19 \u00e0 24 ans)\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D055815\"\n            }\n        },\n        {\n            \"value\": \"Adulte (25 \u00e0 44 ans)\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D000328\"\n            }\n        },\n        {\n            \"value\": \"Adulte (45 \u00e0 64 ans)\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D008875\"\n            }\n        },\n        {\n            \"value\": \"Personne \u00e2g\u00e9e (65 \u00e0 79 ans)\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D000368\"\n            }\n        },\n        {\n            \"value\": \"Grand \u00e2ge (80 ans et plus)\",\n            \"concept\": {\n                \"vocab\": \"MeSH\",\n                \"vocabURI\": \"http:\\\/\\\/id.nlm.nih.gov\\\/mesh\\\/D000369\"\n            }\n        }\n    ],\n    \"level_type_clusion_I\": \"Patients\",\n    \"level_type_clusion_other\": \"\",\n    \"clusion_I\": \"femmes porteuses de mutation BRCA1\\\/2 indemnes ou ayant \u00e9t\u00e9 atteintes de cancer du sein et\\\/ou de l'ovaire\",\n    \"clusion_E\": \"\"\n}","data_kind":"['Donn\u00e9es cliniques','Donn\u00e9es paracliniques','Donn\u00e9es biologiques']","quality_statement":{"standards":[{"name":"","committee":"","governance":""}],"other_quality_statement":""}},"study_development":{"development_activity":[{"activity_type":"primary evaluation","activity_description":"Ev\u00e9nements de sant\u00e9\/morbidit\u00e9\r\nEv\u00e9nements de sant\u00e9\/mortalit\u00e9"}]},"method":{"data_collection":{"time_method":"Etude transversale non r\u00e9p\u00e9t\u00e9e","frequency":"","sampling_procedure":"['{\"concept\":{\"vocabURI\":\"Other\",\"vocab\":\"CESSDA\"},\"value\":\"Autre\"}']","sample_frame":{"frame_unit":{"unit_type":"['Via des structures (services ou \u00e9tablissements de sant\u00e9, \u00e9coles, entreprises\u2026)']"}},"coll_mode":["{\"concept\":{\"vocabURI\":\"Other\",\"vocab\":\"CESSDA\"},\"value\":\"Autre\"}"],"research_instrument":"Acc\u00e8s restreint sur projet sp\u00e9cifique","sources":[],"target_sample_size":"[1000-10000[ individus","response_rate":"3661 (BRCA1 : 2471 ; BRCA2 : 1190)."},"method_notes":"Etude observationnelle","study_class":"\u00c9tude compl\u00e9t\u00e9e","notes":[{"subject":"research type","values":["Etude observationnelle"]}]},"data_access":{"dataset_availability":{"access_place":"","complete":"","status":"{\"value\":\"A 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