GFRS- 3 GENERATIONS-SCLERODERMA FRESH-PEF5194-en Nathalie LAMBERT GFRS- 3 GENERATIONS-SCLERODERMA 3GENSSC FRESH-PEF5194-en 5194 FRESH-PEF5194 Nathalie LAMBERT INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) Epidemiology France Portal (PEF) INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) null Nathalie;LAMBERT HLA genotyping family members compatibility microchimerism autoimmunity markers Dermatology Biological determinants: Genetic predisposition Biological determinants To form the first French cohort of 3 generations of subjects who have scleroderma (SSc). To carry out HLA (human leukocyte antigen) genotyping for all subjects and family members so as to understand the relationship between HLA compatibility between SSc patients with and members of their family and to further study the role of microchimerism and maternal-foetal compatibility. To continue studies previously undertaken on the preponderance of autoimmune disease in women and to research new markers of SSc on a larger number of subjects. null France Individuals Patients population Male Female Child (6 to 12 years) Young Adult (19 to 24 years) Adult (25 to 44 years) Middle Aged (45 to 64 years) Aged (65 to 79 years) Aged, 80 and over (80 years and more) Women whose parents are still alive and whose children wish to participate in the study. Clinical data Health event/morbidity Health event/mortality Other Through organizations (health services or institutions schools businesses etc.) < 500 individuals Physical/biological measurements (blood pressure, weight, biochemistry, imaging, etc.) Observational Study Observational Study 400 Unknown Restricted access Access on specific project only